The Periodontal-Cardiovascular alliance: Evaluation of miRNA-146a in subgingival plaque samples of chronic periodontitis patients with and without coronary heart disease

Q1 Medicine Journal of Investigative and Clinical Dentistry Pub Date : 2019-07-23 DOI:10.1111/jicd.12442

Krutika Yagnik, Jaideep Mahendra, V. M. Kurian

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引用次数: 15

Abstract

Aim

To quantify the levels of miRNA-146a in subgingival plaque samples, and correlate with periodontal and cardiac parameters, in chronic periodontitis patients with and without coronary heart disease.

Methods

The study involved 90 subjects; 30 patients with chronic periodontitis and coronary heart disease (CP + CHD) as part of Group I; group II comprising 30 with chronic periodontitis alone (CP); and group III comprising 30 systemically healthy controls. Demographic variables, periodontal parameters such as plaque index, bleeding on probing, probing pocket depth and clinical attachment levels, cardiac parameters such as total cholesterol, high-density lipoprotein, low-density lipoprotein, triglyceride levels, and systolic and diastolic blood pressure were recorded from the patients. miRNA-146a level was analyzed in subgingival plaque samples by real-time polymerase chain reaction assay and correlated with periodontal and cardiac parameters.

Results

miRNA-146a showed the highest levels in the CP + CHD group and also showed a positive correlation with body mass index, and periodontal and cardiac parameters.

Conclusion

miRNA-146a is involved in the pathogenesis of both periodontitis and coronary heart disease.

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牙周-心血管联盟:伴有或不伴有冠心病的慢性牙周炎患者龈下菌斑样本中miRNA-146a的评估

目的量化患有和不患有冠心病的慢性牙周炎患者龈下斑块样本中miRNA-146a的水平，并与牙周和心脏参数相关。方法本研究涉及90名受试者；30例慢性牙周炎和冠心病患者作为I组的一部分；第II组包括30例单独患有慢性牙周炎（CP）的患者；第III组包括30个系统健康对照。记录患者的人口学变量、牙周参数（如斑块指数）、探查出血、探查袋深度和临床附着水平、心脏参数（如总胆固醇、高密度脂蛋白、低密度脂蛋白和甘油三酯水平）以及收缩压和舒张压。通过实时聚合酶链反应分析分析龈下斑块样本中的miRNA-146a水平，并与牙周和心脏参数相关。结果CP+CHD组血清miRNA-146a水平最高，且与体重指数、牙周和心脏参数呈正相关。结论miRNA-146a参与牙周炎和冠心病的发病机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Investigative and Clinical Dentistry DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.90

自引率

0.00%

发文量

期刊介绍： Journal of Investigative and Clinical Dentistry (JICD) aims to publish quality, peer reviewed original research and topical reviews on all aspects of investigative and clinical dentistry and craniofacial research, including molecular studies related to oral health and disease. Although international in outlook, the Editor especially encourages papers from the Asia Pacific. The journal also aims to provide clinicians, scientists and students of dentistry with a knowledge transfer platform for rapid publication of reports through an international journal, which will be available free online until 2012. Its scope, therefore, is broad, inclusive and international, but with a particular focus on Asia Pacific. The Editor welcomes manuscripts in the following key thematic areas in oral and maxillofacial sciences: Community Dentistry and Oral Epidemiology, Conservative Dentistry, Dental Biomaterials, Dental Pedagogy, Endodontics and Traumatology, Implant Dentistry, Oral Biosciences, Oral and Maxillofacial Surgery, Oral Medicine, Oral Pathology and Oral Microbiology, Orthodontics, Oral Radiology, Oral Rehabilitation, Paedodontics, Periodontology and Periodontal Medicine.

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