Changes in Serum Fatty Acids Levels during Pregnancy and After Delivery in a Longitudinal Study

Luisa Fernanda Bohorquez-Villamizar, M. Garcés, N. E. Poveda, Elizabeth Sanchez, H. Alvarado-Quintero, Héctor Fabio Sandoval-alzate, E. Rueda, C. Diéguez, R. Nogueiras, J. Caminos
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引用次数: 1

Abstract

Introduction: During pregnancy, several maternal metabolic adaptations occur. One of these adaptations is the significant changes in lipid metabolism which contribute to the nutrient balance of the fetal-placental unit, essential for fetal development and lactation.Methods: In this study, serum concentration of different fatty acids in healthy pregnant women and three months postpartum were determined by capillary gas chromatography and compared to healthy non-pregnant women and men. Differences between groups were assessed with one-way analyses of variance and the post hoc Tukey-HSD test for multiple comparisons. The Mann-Whitney U test was used when a variable was not normally distributed. All statistical analyses were conducted using R statistical Software (version 3.3.1).Results: The results showed that serum levels of these maternal fatty acids increased significantly from the middle until the end of pregnancy compared to non-pregnant women and decreased at postpartum. Saturated fatty acids were observed to contribute to the highest percentage of total serum fatty acids during gestation, followed by polyunsaturated and monounsaturated fatty acids. Additionally, serum levels of total, saturated, monounsaturated, polyunsaturated and TRAN’s fatty acids were significantly elevated in healthy non-pregnant women when compared with men.Conclusion: There are significant differences in the lipid profiles among pregnant and non-pregnant women and men, with a decrease in the serum profile of all fatty acids in the postpartum period.
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在一项纵向研究中,妊娠期间和分娩后血清脂肪酸水平的变化
引言:在怀孕期间,母体会发生几种代谢适应。其中一种适应是脂质代谢的显著变化,这有助于胎儿胎盘单元的营养平衡,这对胎儿发育和哺乳至关重要。方法:采用毛细管气相色谱法测定健康孕妇和产后三个月血清中不同脂肪酸的浓度,并与健康非孕妇和男性进行比较。通过单向方差分析和事后Tukey HSD检验进行多重比较来评估各组之间的差异。当变量不是正态分布时,使用Mann-Whitney U检验。所有统计分析均使用R统计软件(3.3.1版)进行。结果:与非孕妇相比,从妊娠中期到妊娠结束,这些母体脂肪酸的血清水平显著升高,产后则有所下降。在妊娠期,饱和脂肪酸占血清总脂肪酸的百分比最高,其次是多不饱和脂肪酸和单不饱和脂肪酸类。此外,与男性相比,健康非孕妇的血清总、饱和、单不饱和、多不饱和和TRAN脂肪酸水平显著升高。结论:孕妇、非孕妇和男性的血脂水平存在显著差异,产后血清中所有脂肪酸水平均有所下降。
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