Effects of Caffeic Acid on Multi-Walled Carbon Nanotubes -Induced Mitochondrial Toxicity in Rat Kidney

IF 1 Q4 PHARMACOLOGY & PHARMACY Jundishapur Journal of Natural Pharmaceutical Products Pub Date : 2023-04-22 DOI:10.5812/jjnpp-133171
M. Salehcheh, L. Zeidooni, M. Dehghani, Soheila Alboghobeish, M. Shirani
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Abstract

: Multi-walled carbon nanotubes (MWCNTs) are being utilized in various fields. With regard to their numerous applications, MWCNT-induced toxicity has not been extensively investigated. Thus, the present study sheds light on the protective effect of caffeic acid (CA) on mitochondrial toxicity in the kidney caused by MWCNTs in Wistar rats employing the MTT assay as well as reactive oxygen species (ROS) indices, based on measuring glutathione (GSH), mitochondrial membrane potential (MMP), malondialdehyde (MDA), and catalase (CAT) activity. According to the MTT assay, using MWCNTs could significantly diminish mitochondrial viability based on doses. Furthermore, the study findings suggested that MWCNTs could reduce GSH content and CAT activity and subsequently improve mitochondrial ROS formation and damage the mitochondrial membrane of the kidney. The findings also implied that CA could protect renal mitochondria against toxicity induced by MWCNTs by lowering oxidative stress.
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咖啡酸对多壁碳纳米管诱导的大鼠肾脏线粒体毒性的影响
:多壁碳纳米管(MWCNTs)被用于各种领域。就其众多应用而言,MWCNT诱导的毒性尚未得到广泛研究。因此,本研究采用MTT法以及基于谷胱甘肽(GSH)、线粒体膜电位(MMP)、丙二醛(MDA)和过氧化氢酶(CAT)活性的活性氧(ROS)指数,阐明了咖啡酸(CA)对MWCNTs引起的Wistar大鼠肾脏线粒体毒性的保护作用。根据MTT测定,基于剂量,使用MWCNTs可以显著降低线粒体活力。此外,研究结果表明,MWCNTs可以降低GSH含量和CAT活性,从而改善线粒体ROS的形成并损伤肾脏的线粒体膜。研究结果还表明,CA可以通过降低氧化应激来保护肾线粒体免受MWCNTs诱导的毒性。
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CiteScore
1.40
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0.00%
发文量
26
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