Food colloid-based delivery systems for tackling age-related macular degeneration by enhancing carotenoid bioavailability: A review

IF 4.6 Q1 CHEMISTRY, APPLIED Food Hydrocolloids for Health Pub Date : 2022-12-01 DOI:10.1016/j.fhfh.2022.100093
Erin Kuo , David Julian McClements
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引用次数: 1

Abstract

Over the past century, there has been a large increase in the life expectancy of people around the globe, which means there has been a rise in diseases of the elderly. Age-related macular degeneration (AMD) is a sight-threatening condition of the eye characterized by a loss of central vision. Research suggests that macular pigment carotenoids, such as lutein and zeaxanthin, may inhibit the onset of this disease by protecting the eye from damaging light and oxidation. These carotenoids are chemically reactive hydrophobic molecules with a low water-solubility, chemical stability, and bioavailability. Consequently, many carotenoid-rich foods and supplements are not absorbed by the human body and do not exhibit their beneficial effects on eye health. In this article, we review the prevalence and characteristics of AMD, the sources of macular pigment carotenoids in foods, the factors limiting their bioavailability, and analytical approaches available to study their bioavailability and bioactivity. We then discuss different strategies for increasing the concentration of bioavailable macular pigment carotenoids in the human diet, including dietary sources, supplements, functional foods, and excipient foods, with an emphasis on colloidal systems that can be used for this purpose.

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通过提高类胡萝卜素的生物利用度来治疗老年性黄斑变性的食物胶体为基础的输送系统:综述
在过去的一个世纪里,全球人口的预期寿命大幅增加,这意味着老年人的疾病有所增加。老年性黄斑变性(AMD)是一种以中心视力丧失为特征的眼睛视力威胁疾病。研究表明,黄斑色素类胡萝卜素,如叶黄素和玉米黄质,可能通过保护眼睛免受有害的光和氧化而抑制这种疾病的发生。这些类胡萝卜素是化学反应性疏水分子,具有低水溶性、化学稳定性和生物利用度。因此,许多富含类胡萝卜素的食物和补充剂不能被人体吸收,也不能显示出它们对眼睛健康的有益作用。本文综述了黄斑变性的发病率和特点、食品中黄斑色素类胡萝卜素的来源、限制其生物利用度的因素以及研究其生物利用度和生物活性的分析方法。然后,我们讨论了增加人类饮食中生物可利用黄斑色素类胡萝卜素浓度的不同策略,包括饮食来源、补充剂、功能性食品和辅料食品,重点介绍了可用于此目的的胶体系统。
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来源期刊
CiteScore
4.50
自引率
0.00%
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0
审稿时长
61 days
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