A single dose of aged garlic extract did not change cerebral oxygenation and blood volume in older adults at cardiovascular risk factors

IF 2.4 Q3 NUTRITION & DIETETICS PharmaNutrition Pub Date : 2023-09-01 DOI:10.1016/j.phanu.2023.100345

Mônica Volino-Souza , Gustavo Vieira de Oliveira , Renata Leitão , Leandro Lara de Carvalho , Thiago da Silveira Alvares

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Abstract

Background

and Aims: Ageing is associated with impaired endothelial function, which can negatively affect cerebral blood flow (CBF). The present study evaluated whether aged garlic extract (AGE) could improve cerebral oxygenation and blood volume due to the possible vasoactive effect. Methods and Results: Fourteen older adults were enrolled in a randomized, double-blind, cross-over study. Urinary thiosulfate and plasma nitrite was drawn, and participants ingested 2.4 g of AGE or placebo. A handgrip exercise protocol started 180 min after supplementation to induce brain activation, and cerebral oxygenation and blood volume were evaluated by near-infrared spectroscopy. After exercise, urinary thiosulfate and plasma nitrite were re-evaluated. AGE supplementation did not change cerebral oxygenation and blood volume. In addition, urinary thiosulfate and plasma nitrite remained unchanged after supplementation. Conclusion: A single dose of AGE (2.4 g) could not increase nitrite levels and cerebral oxygenation and blood volume in older adults at cardiovascular risk factors (NCT04008693).

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单剂量老化大蒜提取物不会改变心血管危险因素老年人的脑氧合和血容量

背景和目的：衰老与内皮功能受损有关，内皮功能受损会对脑血流量产生负面影响。本研究评估了老化大蒜提取物（AGE）是否因其可能的血管活性作用而改善脑氧合和血容量。方法和结果：14名老年人参加了一项随机、双盲、交叉研究。抽取尿硫代硫酸盐和血浆亚硝酸盐，参与者摄入2.4克AGE或安慰剂。在补充后180分钟开始抓握运动方案，以诱导大脑激活，并通过近红外光谱评估大脑氧合和血容量。运动后，对尿硫代硫酸盐和血浆亚硝酸盐进行重新评估。补充AGE不会改变脑氧合和血容量。此外，补充后尿硫代硫酸盐和血浆亚硝酸盐保持不变。结论：单剂量AGE（2.4g）不能增加心血管危险因素老年人的亚硝酸盐水平、脑氧合和血容量（NCT04008693）。

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