Treadmill exercise during pregnancy decreases serum asprosin in rats with gestational diabetes mellitus

Q2 Medicine Obesity Medicine Pub Date : 2023-09-01 DOI:10.1016/j.obmed.2023.100511

Alireza Ayyoubi , Motahare Parsi Mood , Hamid Hafezinori , Hossein Nakhaei , Hamed Fanaei

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Abstract

Objective

Asprosin is a newly discovered hormone that is primarily secreted by white adipose tissue and plays a crucial role in regulating glucose metabolism. Recent studies have shown that asprosin levels are significantly elevated in patients with gestational diabetes mellitus (GDM), which suggests that it may play a role in the pathogenesis of this condition. The idea of this study was to investigate the effect of treadmill exercise during pregnancy on serum asprosin concentration in rats with GDM.

Materials and methods

Forty female Wistar rats (weighing 250–270 g) were randomly assigned into four groups: control (Ctr) group, control + Exercise (Ctr + Exc) group, gestational diabetes mellitus (GDM) group, and GDM + Exercise (GDM + Exc) group. Ctr + Exc and GDM + Exc groups underwent treadmill exercise during pregnancy. Maternal weight during pregnancy period, birth weight of oﬀspring, levels of fasting blood glucose (FBS), insulin and asprosin level were measured.

Results

Serum Asprosin concentration in the GDM group was significantly higher than Ctr and Ctr + Exc groups (P < 0.0001), on the other hand, asprosin level in the GDM + Exc group was significantly lower than in the GDM group (P < 0.0001).

The weight of the GDM group was significantly higher than the Ctr and Ctr + Exc groups at 20th day of gestation (P > 0.05). Serum FBS and insulin levels in the GDM + Exc group were significantly lower than GDM group (P < 0.001 and P < 0.0001, respectively).

Conclusion

Based on the results of our study, treadmill exercise can be an effective intervention to regulate asprosin secretion and metabolism, as a preferred non-pharmacological treatment in GDM.

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妊娠期平板运动降低妊娠期糖尿病大鼠血清asp松香含量

目的脂肪蛋白酶是一种新发现的主要由白色脂肪组织分泌的激素，在调节葡萄糖代谢中起重要作用。最近的研究表明，asprosin水平在妊娠期糖尿病(GDM)患者中显著升高，这表明它可能在该疾病的发病机制中发挥作用。本研究旨在探讨妊娠期跑步机运动对妊娠期GDM大鼠血清阿霉素浓度的影响。材料与方法体重250 ~ 270 g的雌性Wistar大鼠40只，随机分为4组:对照组(Ctr)组、对照组+运动(Ctr + Exc)组、妊娠期糖尿病(GDM)组和妊娠期糖尿病+运动(GDM + Exc)组。Ctr + Exc组和GDM + Exc组在怀孕期间进行跑步机锻炼。测定孕妇孕期体重、子代出生体重、空腹血糖(FBS)水平、胰岛素和阿泌素水平。结果GDM组血清Asprosin浓度显著高于Ctr和Ctr + Exc组(P <0.0001)，另一方面，GDM + Exc组的asprosin水平显著低于GDM组(P <0.0001)。妊娠第20天，GDM组体重显著高于Ctr和Ctr + Exc组(P >0.05)。GDM + Exc组血清FBS和胰岛素水平显著低于GDM组(P <0.001和P <分别为0.0001)。结论根据我们的研究结果，跑步机运动可以有效干预阿斯丁蛋白酶的分泌和代谢，是GDM的首选非药物治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity Medicine Medicine-Public Health, Environmental and Occupational Health

CiteScore

5.50

自引率

0.00%

发文量

审稿时长

40 days

期刊介绍： The official journal of the Shanghai Diabetes Institute Obesity is a disease of increasing global prevalence with serious effects on both the individual and society. Obesity Medicine focusses on health and disease, relating to the very broad spectrum of research in and impacting on humans. It is an interdisciplinary journal that addresses mechanisms of disease, epidemiology and co-morbidities. Obesity Medicine encompasses medical, societal, socioeconomic as well as preventive aspects of obesity and is aimed at researchers, practitioners and educators alike.