Noncatalytic Function of a JmjC Domain Protein Disrupts Heterochromatin

IF 3.2 Q2 GENETICS & HEREDITY Epigenetics Insights Pub Date : 2019-01-01 DOI:10.1177/2516865719862249
Kehan Bao, S. Jia
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引用次数: 1

Abstract

Chromatin-modifying enzymes are frequently overexpressed in cancer cells, and their enzymatic activities play important roles in changing the epigenetic landscape responsible for tumorigenesis. However, many of these proteins also execute noncatalytic functions, which are poorly understood. In fission yeast, overexpression of Epe1, a histone demethylase homolog, causes heterochromatin defects. Interestingly, in our recent work, we discovered that overexpressed Epe1 recruits SAGA, a histone acetyltransferase complex important for transcriptional regulation, to disrupt heterochromatin, independent of its demethylase activity. Our findings suggest that overexpressed chromatin-modifying enzymes can alter the epigenetic landscape through changing their proteomic environments, an area that needs to be further explored in dissecting disease etiology associated with overexpression of chromatin regulators.
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JmjC结构域蛋白的非催化功能破坏异染色质
染色质修饰酶在癌症细胞中经常过表达,其酶活性在改变导致肿瘤发生的表观遗传学景观中发挥着重要作用。然而,这些蛋白质中的许多也执行非催化功能,这一点尚不清楚。在分裂酵母中,组蛋白去甲基化酶同源物Epe1的过度表达会导致异染色质缺陷。有趣的是,在我们最近的工作中,我们发现过表达的Epe1招募了SAGA,一种对转录调控很重要的组蛋白乙酰转移酶复合物,以破坏异染色质,而不依赖于其去甲基化酶活性。我们的研究结果表明,过表达的染色质修饰酶可以通过改变其蛋白质组环境来改变表观遗传学景观,这一领域在分析与染色质调节因子过表达相关的疾病病因时需要进一步探索。
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来源期刊
Epigenetics Insights
Epigenetics Insights GENETICS & HEREDITY-
CiteScore
5.10
自引率
0.00%
发文量
10
审稿时长
8 weeks
期刊最新文献
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