Recent advances in the microfluidic generation of shape-controllable hydrogel microparticles and their applications

IF 9.1 Q1 ENGINEERING, CHEMICAL Green Chemical Engineering Pub Date : 2023-02-28 DOI:10.1016/j.gce.2023.02.002
Yingzhe Liu, Zhuo Chen, Jianhong Xu
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Abstract

Hydrogel microparticles, generally accepted as significant green materials, have been widely used in chemical, biological, and biomedical fields owing to their excellent biocompatibility, biodegradability, and non-cytotoxicity. Among these, non-spherical hydrogel microparticles with diverse shape anisotropy have great potential in applications such as drug delivery, cellular interaction, micromotors, etc. Benefiting from their shapes, their functionalities in such fields cannot be satisfied by the typical spherical types. Recently, microfluidics with precise control and domination of fluids at microflow sizes has emerged as a powerful method for synthesizing shape-controllable hydrogel microparticles with good monodispersity and unique morphology. In this review, we tried to provide an overview of the production of non-spherical microparticles composed of green hydrogel materials, emphasizing the microfluidic approaches. Furthermore, a brief introduction to their current applications is also presented.

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形状可控水凝胶微粒的微流体生成及其应用研究进展
水凝胶微颗粒是公认的重要绿色材料,因其具有良好的生物相容性、生物降解性和无细胞毒性,已被广泛应用于化学、生物和生物医学领域。其中,具有各种形状各向异性的非球形水凝胶微粒在药物输送、细胞相互作用、微电机等方面具有巨大的应用潜力。由于其形状的优势,典型的球形微粒无法满足它们在这些领域的功能需求。最近,在微流尺寸下精确控制和支配流体的微流体技术已成为合成具有良好单分散性和独特形态的形状可控水凝胶微颗粒的有力方法。在本综述中,我们试图概述由绿色水凝胶材料组成的非球形微颗粒的生产情况,重点介绍微流体方法。此外,还简要介绍了它们目前的应用情况。
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来源期刊
Green Chemical Engineering
Green Chemical Engineering Process Chemistry and Technology, Catalysis, Filtration and Separation
CiteScore
11.60
自引率
0.00%
发文量
58
审稿时长
51 days
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