Reham El Shimy Salwa Hassan Teama, H. Gamal, Salwa Teama
{"title":"Combined Human Epididymis 4 and Carbohydrate Antigen 125 Serum Protein Levels Diagnostic value in Ovarian Cancer","authors":"Reham El Shimy Salwa Hassan Teama, H. Gamal, Salwa Teama","doi":"10.18689/mjcsr-1000108","DOIUrl":null,"url":null,"abstract":"Results: The results showed that increased serum protein concentration of HE-4 (pMol/L) and CA-125 (U/ml) in the ovarian cancer group mean (SD)/median (range) 329.61±336.55/199 (28.72-1064) and 521.36±572.60/287 (10.50-2377), than non-cancer control group 64.80±38.51/54.53 (21 -160) and 28.35±10.80/28 (10-50) respectively (p<0.05). The receiver operating characteristic curve, the area under the curve (ROC-AUC) (95%CI) values of serum HE-4 was 0.85 (0.74-0.95). The sensitivity and specificity of HE-4 in diagnosing malignant ovarian tumors was 84.84% and 75.00%, respectively at ideal cutoff point that provided the best and highest accuracy in our own study and its level was related to clinical staging.","PeriodicalId":92819,"journal":{"name":"Madridge journal of cancer study & research","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2018-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Madridge journal of cancer study & research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18689/mjcsr-1000108","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Results: The results showed that increased serum protein concentration of HE-4 (pMol/L) and CA-125 (U/ml) in the ovarian cancer group mean (SD)/median (range) 329.61±336.55/199 (28.72-1064) and 521.36±572.60/287 (10.50-2377), than non-cancer control group 64.80±38.51/54.53 (21 -160) and 28.35±10.80/28 (10-50) respectively (p<0.05). The receiver operating characteristic curve, the area under the curve (ROC-AUC) (95%CI) values of serum HE-4 was 0.85 (0.74-0.95). The sensitivity and specificity of HE-4 in diagnosing malignant ovarian tumors was 84.84% and 75.00%, respectively at ideal cutoff point that provided the best and highest accuracy in our own study and its level was related to clinical staging.
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