Incidence and Predictors of Pregnancy among HIV Positive Women on ART in North West Ethiopia, a Retrospective Cohort Study

Gebrie Yenesew Fentahun, Dessie Tadesse Mihretie, Yeshiwas Dawit
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Abstract

Objective: The objective of this study was to identify the prevalence and significant factors of incidence of pregnancy among HIV positive women under ART follow up. Methods: A retrospective cohort study was employed and a sample size of 429 was selected using simple random sampling technique. Both chi-square test of association and multiple binary logistic regression analysis were used. Results: The study has shown that 21.2% of women were pregnant during the follow-up. Variables like, WHO clinical stage, spouse’s HIV status, marital status, contraception use, body weight, occupation, CD4 count, age and time of ART were significant predictors of incidence of pregnancy. Conclusion: Women with advance WHO clinical stage were less likely to be pregnant. Women, who are married, employed, had never used contraceptive methods were more likely to had pregnancy. When CD4 cell count and body weight increase, incidence of pregnancy also increases and women who had longer time on ART were more likely to be pregnant. Health institutions and clinicians should be cautious when the patients have faced advanced WHO clinical stage and low CD4 count. We would like to put remarks of increasing employment of HIV Positive women, providing effective services of ART health care, and studying further investigation for the general wellbeing of mothers and their respective potentially born children.
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埃塞俄比亚西北部接受ART治疗的HIV阳性妇女的妊娠发生率和预测因素:一项回顾性队列研究
目的:本研究的目的是确定在接受ART随访的HIV阳性妇女中妊娠的患病率和重要因素。方法:采用回顾性队列研究,采用简单随机抽样技术选择429名样本。采用关联卡方检验和多元二元逻辑回归分析。结果:研究表明,21.2%的妇女在随访期间怀孕。世界卫生组织临床分期、配偶HIV状况、婚姻状况、避孕方法、体重、职业、CD4计数、ART年龄和时间等变量是妊娠发生率的重要预测因素。结论:世界卫生组织临床分期提前的妇女怀孕的可能性较低。已婚、有工作、从未使用过避孕方法的女性更有可能怀孕。当CD4细胞计数和体重增加时,妊娠发生率也会增加,接受ART时间较长的女性更有可能怀孕。当患者面临世界卫生组织晚期临床阶段和低CD4计数时,卫生机构和临床医生应谨慎。我们想谈谈增加艾滋病毒阳性妇女的就业,提供有效的抗逆转录病毒疗法医疗保健服务,并研究进一步调查母亲及其潜在出生子女的总体健康状况。
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