Ecotoxicological Effects of Diethyl Phthalate on Caenorhabditis elegans under Environmentally Relevant Concentrations

Q2 Environmental Science 环境科学研究 Pub Date : 2020-09-01 DOI:10.13198/J.ISSN.1001-6929.2020.04.02
严晨之, 曹雪, 周磊, 修光利
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Abstract

Diethyl phthalate(DEP)is a typical plasticizer that has been widely detected in the environment.DEP possesses potential neurological and reproductive toxicities,which can affect the development motion behavior as well as certain biochemical parameters of organisms.The present study was designed to evaluate the eco-toxicity of DEP under different exposure scenarios(24 h,72 h and 10 d)at environmentally relevant concentrations(0,0.0002,0.002,0.02,0.2,2 mg /L)on Caenorhabditis elegans,a typical model animal.To this end,the body length width,head thrashing frequency,and biochemical indicators of C.elegans were applied as test endpoints to evaluate the ecotoxicological effects of DEP.The results revealed that under 24 h exposure scenario,compared to the control group,DEP exhibited no distinct effect on the development of C.elegans at all exposure levels(P>0.05).In the case of 72 h exposure,DEP was found to inhibit the development of C.elegans compared with the control group.Specifically,the body length declined by 3.21%(P<0.05)at a DEP level of 2 mg/ L.Under 0.0002 mg /L DEP exposure,the body width was found to increase.Head thrashing frequency displayed stimulating effect when exposed to low DEP levels(<0.2 mg /L).When it was 0.0002 mg/ L,it increased by 5.52%(P<0.01).In addition,the physiological endpoints,including body length,body width and head thrashing frequency,decreased significantly by comparison with the control group at all exposure levels after 10 d exposure.Moreover,the levels of reactive oxygen species,lipofuscin and apoptosis increased significantly at 2 mg/ L.The results revealed that DEP exposure exhibited different toxicological effects on C.elegans,depending on the concentration and exposure scenarios.
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环境相关浓度下邻苯二甲酸二乙酯对秀丽隐杆线虫的生态毒性作用
邻苯二甲酸二乙酯(DEP)是一种典型的增塑剂,已在环境中广泛检测。DEP具有潜在的神经和生殖毒性,可影响生物体的发育运动行为以及某些生化参数。本研究旨在评估DEP在环境相关浓度(0,0.0002,0.002,0.02,0.2,2mg/L)的不同暴露场景(24小时、72小时和10天)下对秀丽隐杆线虫(一种典型的模型动物)的生态毒性。为此,以秀丽隐杆线虫的体长宽度、头部拍打频率和生化指标为测试终点,评估DEP的生态毒理学效应。结果显示,在暴露24小时的情况下,与对照组相比,在所有暴露水平下,DEP对秀丽隐杆虫的发育均无明显影响(P>0.05),与对照组相比,发现DEP抑制秀丽隐杆线虫的发育。具体而言,在2 mg/L的DEP水平下,体长下降了3.21%(P<0.05)。在0.0002 mg/L的DEP暴露下,发现体宽增加。当暴露于低浓度DEP(<0.2mg/L)时,头部拍打频率表现出刺激作用,当暴露于0.0002mg/L时,其增加了5.52%(P<0.01)。此外,在所有暴露水平下,暴露10d后,生理终点,包括体长、体宽和头部拍打频率,与对照组相比均显著降低。此外,2 mg/L时,活性氧、脂褐素和细胞凋亡水平显著增加。结果表明,DEP暴露对秀丽隐杆线虫表现出不同的毒理学影响,这取决于浓度和暴露情况。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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文献相关原料
公司名称产品信息其他信息采购帮参考价格
上海吉至 二甲基亚砜
D54265 99%
¥20.00~¥221931.13
阿拉丁 吖啶橙
99%
¥25.00~¥19242.00
阿拉丁 DEP
99.5%
¥22.00~¥7913.00
阿拉丁 2,7 - 二氯二氢荧光素二乙酸酯
97%
¥391.00~¥5200.00
来源期刊
环境科学研究
环境科学研究 Environmental Science-Environmental Science (miscellaneous)
CiteScore
3.80
自引率
0.00%
发文量
6496
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