Ecotoxicological Effects of Diethyl Phthalate on Caenorhabditis elegans under Environmentally Relevant Concentrations

Q2 Environmental Science 环境科学研究 Pub Date : 2020-09-01 DOI:10.13198/J.ISSN.1001-6929.2020.04.02
严晨之, 曹雪, 周磊, 修光利
{"title":"Ecotoxicological Effects of Diethyl Phthalate on Caenorhabditis elegans under Environmentally Relevant Concentrations","authors":"严晨之, 曹雪, 周磊, 修光利","doi":"10.13198/J.ISSN.1001-6929.2020.04.02","DOIUrl":null,"url":null,"abstract":"Diethyl phthalate(DEP)is a typical plasticizer that has been widely detected in the environment.DEP possesses potential neurological and reproductive toxicities,which can affect the development motion behavior as well as certain biochemical parameters of organisms.The present study was designed to evaluate the eco-toxicity of DEP under different exposure scenarios(24 h,72 h and 10 d)at environmentally relevant concentrations(0,0.0002,0.002,0.02,0.2,2 mg /L)on Caenorhabditis elegans,a typical model animal.To this end,the body length width,head thrashing frequency,and biochemical indicators of C.elegans were applied as test endpoints to evaluate the ecotoxicological effects of DEP.The results revealed that under 24 h exposure scenario,compared to the control group,DEP exhibited no distinct effect on the development of C.elegans at all exposure levels(P>0.05).In the case of 72 h exposure,DEP was found to inhibit the development of C.elegans compared with the control group.Specifically,the body length declined by 3.21%(P<0.05)at a DEP level of 2 mg/ L.Under 0.0002 mg /L DEP exposure,the body width was found to increase.Head thrashing frequency displayed stimulating effect when exposed to low DEP levels(<0.2 mg /L).When it was 0.0002 mg/ L,it increased by 5.52%(P<0.01).In addition,the physiological endpoints,including body length,body width and head thrashing frequency,decreased significantly by comparison with the control group at all exposure levels after 10 d exposure.Moreover,the levels of reactive oxygen species,lipofuscin and apoptosis increased significantly at 2 mg/ L.The results revealed that DEP exposure exhibited different toxicological effects on C.elegans,depending on the concentration and exposure scenarios.","PeriodicalId":21108,"journal":{"name":"环境科学研究","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"环境科学研究","FirstCategoryId":"1087","ListUrlMain":"https://doi.org/10.13198/J.ISSN.1001-6929.2020.04.02","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Environmental Science","Score":null,"Total":0}
引用次数: 0

Abstract

Diethyl phthalate(DEP)is a typical plasticizer that has been widely detected in the environment.DEP possesses potential neurological and reproductive toxicities,which can affect the development motion behavior as well as certain biochemical parameters of organisms.The present study was designed to evaluate the eco-toxicity of DEP under different exposure scenarios(24 h,72 h and 10 d)at environmentally relevant concentrations(0,0.0002,0.002,0.02,0.2,2 mg /L)on Caenorhabditis elegans,a typical model animal.To this end,the body length width,head thrashing frequency,and biochemical indicators of C.elegans were applied as test endpoints to evaluate the ecotoxicological effects of DEP.The results revealed that under 24 h exposure scenario,compared to the control group,DEP exhibited no distinct effect on the development of C.elegans at all exposure levels(P>0.05).In the case of 72 h exposure,DEP was found to inhibit the development of C.elegans compared with the control group.Specifically,the body length declined by 3.21%(P<0.05)at a DEP level of 2 mg/ L.Under 0.0002 mg /L DEP exposure,the body width was found to increase.Head thrashing frequency displayed stimulating effect when exposed to low DEP levels(<0.2 mg /L).When it was 0.0002 mg/ L,it increased by 5.52%(P<0.01).In addition,the physiological endpoints,including body length,body width and head thrashing frequency,decreased significantly by comparison with the control group at all exposure levels after 10 d exposure.Moreover,the levels of reactive oxygen species,lipofuscin and apoptosis increased significantly at 2 mg/ L.The results revealed that DEP exposure exhibited different toxicological effects on C.elegans,depending on the concentration and exposure scenarios.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
环境相关浓度下邻苯二甲酸二乙酯对秀丽隐杆线虫的生态毒性作用
邻苯二甲酸二乙酯(DEP)是一种典型的增塑剂,已在环境中广泛检测。DEP具有潜在的神经和生殖毒性,可影响生物体的发育运动行为以及某些生化参数。本研究旨在评估DEP在环境相关浓度(0,0.0002,0.002,0.02,0.2,2mg/L)的不同暴露场景(24小时、72小时和10天)下对秀丽隐杆线虫(一种典型的模型动物)的生态毒性。为此,以秀丽隐杆线虫的体长宽度、头部拍打频率和生化指标为测试终点,评估DEP的生态毒理学效应。结果显示,在暴露24小时的情况下,与对照组相比,在所有暴露水平下,DEP对秀丽隐杆虫的发育均无明显影响(P>0.05),与对照组相比,发现DEP抑制秀丽隐杆线虫的发育。具体而言,在2 mg/L的DEP水平下,体长下降了3.21%(P<0.05)。在0.0002 mg/L的DEP暴露下,发现体宽增加。当暴露于低浓度DEP(<0.2mg/L)时,头部拍打频率表现出刺激作用,当暴露于0.0002mg/L时,其增加了5.52%(P<0.01)。此外,在所有暴露水平下,暴露10d后,生理终点,包括体长、体宽和头部拍打频率,与对照组相比均显著降低。此外,2 mg/L时,活性氧、脂褐素和细胞凋亡水平显著增加。结果表明,DEP暴露对秀丽隐杆线虫表现出不同的毒理学影响,这取决于浓度和暴露情况。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
文献相关原料
公司名称产品信息其他信息采购帮参考价格
上海吉至 二甲基亚砜
D54265 99%
¥20.00~¥221931.13
阿拉丁 吖啶橙
99%
¥25.00~¥19242.00
阿拉丁 DEP
99.5%
¥22.00~¥7913.00
阿拉丁 2,7 - 二氯二氢荧光素二乙酸酯
97%
¥391.00~¥5200.00
来源期刊
环境科学研究
环境科学研究 Environmental Science-Environmental Science (miscellaneous)
CiteScore
3.80
自引率
0.00%
发文量
6496
期刊介绍:
期刊最新文献
海南省三座典型垃圾填埋场渗滤液及周边地下水中抗生素的污染特征研究 基于SEAR技术的地下含水层石油烃污染修复试验研究 功能化材料Zr@AC对水中难降解农药阿特拉津的去除特征 Microbial Aerosol Investigation and Health Risk Assessment of Residential Area in Wuhan City Analysis of Atmospheric Pollution Status over Nanjing Based on Multi-Source Detection
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1