Carbonate apatite versus β-tricalcium phosphate for rat vertical bone augmentation: A comparison of bioresorbable bone substitutes using polytetrafluoroethylene tubes.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-11-29 Epub Date: 2023-10-17 DOI:10.4012/dmj.2023-112

Makiko Yano, Kenichirou Yasui, Jun-Ichiro Jo, Aki Nishiura, Yoshiya Hashimoto, Naoyuki Matsumoto

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Abstract

This study radiologically and histologically compared two bioresorbable bone substitutes with different compositions carbonate apatite (Cytrans^® Granules; CGs) and β-tricalcium phosphate (β-TCP) for vertical bone augmentation on a rat skull using a polytetrafluoroethylene (PTFE) tubes. This PTFE tube was placed at the center of the skull, fixed with Super Bond, and augmented with CGs or β-TCP granules. Specimens with surrounding tissue were harvested at 4, 8, and 12 weeks postoperatively, and radiological and histological evaluations were performed. The bone volume to total volume ratio (BV/TV) of the β-TCP-implanted group was markedly higher than that of the CG-implanted group at 4 and 12 weeks postoperatively. Compared to CGs, β-TCP exhibited the ability to form blood vessels into the graft material for a short period after transplantation, as well as an elevated production of collagen into β-TCP granules during the bone formation process.

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碳酸磷灰石与β-磷酸三钙用于大鼠垂直骨增强：使用聚四氟乙烯管的生物可吸收骨替代品的比较。

本研究在放射学和组织学上比较了两种具有不同成分的生物可吸收骨替代物碳酸盐磷灰石（Cytrans®颗粒；CGs）和β-磷酸三钙（β-TCP），用于使用聚四氟乙烯（PTFE）管在大鼠颅骨上进行垂直骨增强。该PTFE管放置在颅骨中心，用Super Bond固定，并用CGs或β-TCP颗粒增强。术后4、8和12周采集带周围组织的标本，并进行放射学和组织学评估。术后4周和12周，β-TCP植入组的骨体积与总体积比（BV/TV）显著高于CG植入组。与CGs相比，β-TCP在移植后短时间内表现出在移植物材料中形成血管的能力，并且在骨形成过程中增加了胶原在β-TCP颗粒中的产生。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.