Autophagy Behavior in Endothelial Cell Regeneration.

Basheer Abdullah Marzoog
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Abstract

Autophagy plays a crucial role in maintaining endothelial cell homeostasis through the turnover of intracellular components during stress conditions in a lysosomal-dependent manner. The regeneration strategy involves several aspects, including autophagy. Autophagy is a catabolic degenerative lysosomal-dependent degradation of intracellular components. Autophagy modifies cellular and subcellular endothelial cell functions, including mitochondria stress, lysosomal stress, and endoplasmic reticulum unfolded protein response. Activation of common signaling pathways of autophagy and regeneration and enhancement of intracellular endothelial cell metabolism serve as the bases for the induction of endothelial regeneration. Endothelial progenitor cells include induced pluripotent stem cells (iPSC), embryonic stem cells, and somatic cells, such as fibroblasts. Future strategies of endothelial cell regeneration involve the induction of autophagy to minimize the metabolic degeneration of the endothelial cells and optimize the regeneration outcomes.

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综述文章:内皮细胞再生中的自噬行为。
自噬通过在应激条件下以溶酶体依赖的方式转换细胞内成分,在维持内皮细胞稳态方面发挥着至关重要的作用。再生策略涉及几个方面,包括自噬。自噬是细胞内成分的分解代谢变性溶酶体依赖性降解。自噬改变细胞和亚细胞内皮细胞的功能,包括线粒体应激、溶酶体应激和内质网未折叠蛋白反应。激活自噬和再生的常见信号通路以及增强细胞内内皮细胞代谢是诱导内皮再生的基础。内皮祖细胞包括诱导多能干细胞(iPSC)、胚胎干细胞和体细胞,如成纤维细胞。内皮细胞再生的未来策略包括诱导自噬,以最大限度地减少内皮细胞的代谢退化并优化再生结果。
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来源期刊
Current aging science
Current aging science Medicine-Geriatrics and Gerontology
CiteScore
3.90
自引率
0.00%
发文量
40
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