Neuroprotective Effects of Selegiline Agent Methamphetamine-Prompted Mood-Related Behavior Disorder Mediated Via 5-HT2 and D2 Receptors.

IF 1.7 Q2 MEDICINE, GENERAL & INTERNAL International Journal of Preventive Medicine Pub Date : 2023-06-22 eCollection Date: 2023-01-01 DOI:10.4103/ijpvm.ijpvm_42_22
Mina Gholami, Neda Kaviani, Majid Motaghinejad, Luis Ulloa
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Abstract

Background: Many previous studies demonstrated that methamphetamine (METH) abuses can cause mood-related behavioral changes. Previous studies indicated neuroprotective effects of Selegiline.

Methods: Seventy male Wistar rats were randomly divided into eight groups (10 rats in each group). Group 1 and Group 2 received normal saline and methamphetamine (10 mg/kg) for 21 days, respectively. Groups 3, 4, and 5 were treated simultaneously with methamphetamine and Selegiline with doses of 10, 15, and 20 mg/kg for 21 days. Groups 6 and 7 are methamphetamine-dependent groups which received 15 mg/kg of Selegiline with haloperidol (as D2 receptor antagonist) and trazodone (as 5-HT2 receptor antagonist) for 21 days, respectively. In days 23 and 24, elevated plus maze (EPM) and open-field test (OFT) were conducted to assess motor activity and mood (anxiety and depression) levels.

Results: METH as 10 mg/kg causes reduction of rearing number, ambulation distances, time spent in central square and also number of central square entries in OFT. Also METH administration causes decreases of time spent in open arm and number of open arm entries and increases of time spent in closed arm and number of closed arm entries in EPM. In contrast, Selegiline (of 10, 15, and 20 mg/kg) inhibited behavioral effects of methamphetamine in both OFT and EPM. Also administration of haloperidol and trazodone inhibited these behavioral protective effects of Selegiline and caused decrease of OFT behaviors (rearing number, ambulation distances, time spent in central square, and also number of central square entries) and also caused decreases of spend times in open arm, number of open arm entries, and also increased closed arm time spending and number of entries in closed arm in EPM.

Conclusions: Current research showed that Selegiline via mediation of D2 and 5-HT2 receptors inhibits METH-induced neurobehavioral changes, mood-related behavior, and motor activity disturbances.

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Selegiline制剂甲基苯丙胺通过5-HT2和D2受体介导的情绪相关行为障碍的神经保护作用。
背景:先前的许多研究表明,滥用甲基苯丙胺会导致情绪相关的行为变化。方法:70只雄性Wistar大鼠随机分为8组(每组10只)。第1组和第2组分别接受生理盐水和甲基苯丙胺(10mg/kg)21天。第3组、第4组和第5组同时用甲基苯丙胺和司来吉林治疗,剂量分别为10、15和20mg/kg,持续21天。第6组和第7组是甲基苯丙胺依赖性组,其分别接受15mg/kg的塞雷吉林与氟哌啶醇(作为D2受体拮抗剂)和曲唑酮(作为5-HT2受体拮抗剂。在第23天和第24天,进行了提升加迷宫(EPM)和开放场地测试(OFT),以评估运动活动和情绪(焦虑和抑郁)水平。结果:10 mg/kg的METH可减少OFT的饲养次数、行走距离、在中心广场停留的时间以及中心广场入口的数量。此外,METH给药导致EPM中开放臂花费的时间和开放臂进入次数减少,闭合臂花费的次数和闭合臂进入次数增加。相反,Selegiline(10、15和20 mg/kg)在OFT和EPM中均抑制甲基苯丙胺的行为效应。此外,氟哌啶醇和曲唑酮的给药抑制了赛来吉林的这些行为保护作用,并导致OFT行为(饲养次数、行走距离、在中心广场上花费的时间以及中心广场入口的数量)的减少,还导致在开放臂上花费的次数、开放臂入口的数量的减少,结论:目前的研究表明,塞雷吉林通过介导D2和5-HT2受体抑制METH诱导的神经行为变化、情绪相关行为和运动活动障碍。
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来源期刊
International Journal of Preventive Medicine
International Journal of Preventive Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
4.80%
发文量
107
期刊介绍: International Journal of Preventive Medicine, a publication of Isfahan University of Medical Sciences, is a peer-reviewed online journal with Continuous print on demand compilation of issues published. The journal’s full text is available online at http://www.ijpvmjournal.net. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository. The journal will cover technical and clinical studies related to health, ethical and social issues in field of Preventive Medicine. Articles with clinical interest and implications will be given preference.
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