Associations between Plasma Antibody Levels against Porphyromonas gingivalis and Atrial Fibrillation among Community-Dwelling Older Individuals in Japan: A Cross-Sectional Study.

IF 1.4 4区医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Oral health & preventive dentistry Pub Date : 2023-10-20 DOI:10.3290/j.ohpd.b4528813

Takashi Hoshino, Noboru Kaneko, Akihiro Yoshihara, Masanori Iwasaki, Kana Suwama, Yumi Ito, Junta Tanaka, Ichiei Narita, Hiroshi Ogawa

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Abstract

Purpose: To investigate the association between plasma antibody levels against Porphyromonas gingivalis (PG) and atrial fibrillation (AF) history in community-dwelling older individuals in Japan.

Materials and methods: This study was a subset of the Uonuma cohort study, including 3091 participants aged 60-79 years. Data were collected, including AF history as a dependent variable, plasma immunoglobulin G antibody levels against PG as an independent variable, and previously reported AF risk factors and demographic information as covariates.

Results: The median age of the participants was 69 years. Of the 3091 participants, 1411 (45.6%) were men, and 56 (1.8%) had an AF history. AF prevalence was significantly higher in participants with higher antibody levels against PG than in those with lower antibody levels (3.0% vs 1.4%; p = 0.005). Multivariable logistic regression analysis showed that participants with higher antibody levels against PG had twofold higher odds of having AF (odds ratio = 2.13; 95% confidence interval = 1.23-3.69). Restricted cubic spline analysis indicated a nonlinear relationship between antibody levels against PG and AF history.

Conclusion: Plasma antibody levels against PG were associated with AF history in community-dwelling older individuals in Japan.

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日本社区老年人抗牙龈卟啉单胞菌血浆抗体水平与心房颤动的关系：一项横断面研究。

目的：研究日本社区老年人抗牙龈卟啉单胞菌（PG）血浆抗体水平与心房颤动（AF）史之间的关系。材料和方法：本研究是Uonoma队列研究的一个子集，包括3091名60-79岁的参与者。收集数据，包括房颤病史作为因变量，血浆抗PG免疫球蛋白G抗体水平作为自变量，以及先前报道的房颤风险因素和人口统计信息作为协变量。结果：参与者的中位年龄为69岁。在3091名参与者中，1411名（45.6%）为男性，56名（1.8%）有房颤病史。抗PG抗体水平较高的参与者的AF患病率明显高于抗体水平较低的参与者（3.0%vs 1.4%；p=0.005）。多变量逻辑回归分析显示，抗PG抗体浓度较高的参与者患AF的几率高出两倍（比值比=2.13；95%置信区间=1.23-3.69）。限制性三次样条分析表明针对PG的抗体水平与AF病史之间存在非线性关系。结论：日本社区老年人血浆抗PG抗体水平与房颤病史有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral health & preventive dentistry DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.00

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Clinicians, general practitioners, teachers, researchers, and public health administrators will find this journal an indispensable source of essential, timely information about scientific progress in the fields of oral health and the prevention of caries, periodontal diseases, oral mucosal diseases, and dental trauma. Central topics, including oral hygiene, oral epidemiology, oral health promotion, and public health issues, are covered in peer-reviewed articles such as clinical and basic science research reports; reviews; invited focus articles, commentaries, and guest editorials; and symposium, workshop, and conference proceedings.