Analysis of active surveillance uptake for localized prostate cancer in Quebec in 2016: A Canadian bicentric study and comparison with 2010 data.

IF 0.8 4区 医学 Q4 UROLOGY & NEPHROLOGY Progres En Urologie Pub Date : 2024-01-01 Epub Date: 2023-10-17 DOI:10.1016/j.purol.2023.09.031
C Dariane, F Chierigo, V Ouellet, N Delvoye, M-P Jammal, L R Bégin, J-B Paradis, A-M Mes-Masson, P I Karakiewicz, F Saad
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Abstract

Introduction: Active surveillance (AS) has emerged as a primary management strategy for low-risk prostate cancer (PC) patients. We aimed to assess AS uptake over a 1-year snapshot throughout Quebec and to compare it to 2010 multicentric Canadian data.

Methods: A retrospective chart review and data collection was performed in 1 academic and 2 non-academic community centres from Quebec, among men identified in 2016 with localized T1c-T2c PC on biopsy, fulfilling NCCN criteria of low-risk (LR)-PC, including very-low-risk (VLR) and non-VLR-PC, and favourable-intermediate risk (FIR)-PC. AS adherence was defined when chosen as initial strategy, without any radical treatment within 6 months.

Results: Overall, 259 patients fulfilled the inclusion criteria with 50.2% of VLR-PC patients. At 6 months, 81% patients in the LR group and 65% in the FIR group were considered as adherent to AS, in both centres, but with an increased use of AS in the community centres compared to 2010 data. The rates of AS maintenance decreased at 12 months to respectively 69% and 58%. Among the VLR group, the rate of initiation was 98% and decreased to 85% at 12 months.

Conclusion: Our data suggest that the majority of low-risk PC patients indeed initiated an AS in 2016, with even a greater proportion of VLR-PC patients compared to 2010. This ideal strategy should be encouraged and improved at 12 months, and assessed with recent data and longer follow-up.

Level of evidence: 4:

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魁北克省2016年局部前列腺癌症主动监测摄取分析:加拿大双中心研究及与2010年数据的比较。
简介:主动监测(AS)已成为低风险前列腺癌症(PC)患者的主要管理策略。我们旨在评估魁北克省1年内AS摄取情况,并将其与2010年加拿大多中心数据进行比较。方法:在魁北克的1个学术和2个非学术社区中心进行了回顾性图表审查和数据收集,这些中心的男性于2016年在活检中发现了局限性T1c-T2c PC,符合NCCN的低风险(LR)-PC标准,包括极低风险(VLR)和非VLR PC,以及有利的中风险(FIR)-PC。当选择AS依从性作为初始策略时,定义为在6个月内不进行任何根治性治疗。结果:总的来说,259名患者符合纳入标准,其中50.2%的VLR-PC患者符合标准。6个月时,在两个中心,LR组81%的患者和FIR组65%的患者被认为是as的依从性患者,但与2010年的数据相比,社区中心as的使用有所增加。AS维持率在12个月时分别下降到69%和58%。在VLR组中,起始率为98%,在12个月时降至85%。结论:我们的数据表明,大多数低风险PC患者确实在2016年开始了AS,与2010年相比,VLR-PC患者的比例甚至更高。这种理想的策略应该在12个月时得到鼓励和改进,并根据最近的数据和更长的随访时间进行评估。证据水平:4:
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Progres En Urologie
Progres En Urologie 医学-泌尿学与肾脏学
CiteScore
1.80
自引率
27.30%
发文量
132
审稿时长
54 days
期刊介绍: Une publication rapide des travaux en urologie: retrouvez les derniers travaux de recherche, études et enquêtes, en Urologie, publiés sous la forme de revues, mises au point, articles originaux, notes techniques, cas cliniques pertinents et originaux, lettres à la rédaction, revues de la littérature, textes de recommandation,... La revue publie également des articles pour les infirmières en Urologie. Une approche pluridisciplinaire : Progrès en Urologie aborde toutes les pathologies urologiques. Aux 13 numéros de Progrès viennent s''ajouter 4 numéros de Progrès en Urologie Pelvi-Périnéologie
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