Animal models in peripheral nerve transection studies: a systematic review on study design and outcomes assessment.

IF 2.4 4区医学 Q4 CELL & TISSUE ENGINEERING Regenerative medicine Pub Date : 2024-04-01 Epub Date: 2023-10-19 DOI:10.2217/rme-2023-0102

Bruna Lopes, André Coelho, Rui Alvites, Ana Catarina Sousa, Patrícia Sousa, Alícia Moreira, Luís Atayde, António Salgado, Stefano Geuna, Ana Colette Maurício

引用次数: 0

Abstract

Aim: Peripheral nerve injury regeneration studies using animal models are crucial to different pre-clinical therapeutic approaches efficacy evaluation whatever the surgical technique explored. Materials & methods: A 944 articles systematic review on 'peripheral nerve injury in animal models' over the last 9 years was carried out. Results: It was found that 91% used rodents, and only 9% employed large animals. Different nerves are studied, with generated gaps (10,78 mm) and methods applied for regeneration evaluation uniformed. Sciatic nerve was the most used (88%), followed by median and facial nerves (2.6%), significantly different. Conclusion: There has not been a significant scale-up of the in vivo testing to large animal models (anatomically/physiologically closer to humans), allowing an improvement in translational medicine for clinical cases.

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外周神经横断研究中的动物模型：研究设计和结果评估的系统综述。

目的：使用动物模型进行外周神经损伤再生研究对于不同的临床前治疗方法的疗效评估至关重要，无论探索何种手术技术。材料与方法：对近9年来“动物模型中的外周神经损伤”进行了944篇系统综述。结果：91%的人使用啮齿动物，只有9%的人使用大型动物。研究了不同的神经，产生的间隙（10，78mm）和用于再生评估的方法是一致的。坐骨神经使用最多（88%），其次是正中神经和面神经（2.6%），差异显著。结论：体内测试尚未显著扩大到大型动物模型（在解剖学/生理学上更接近人类），从而改善了临床病例的转化医学。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Regenerative medicine 医学-工程：生物医学

CiteScore

4.20

自引率

3.70%

发文量

审稿时长

6-12 weeks

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