The role of calcitonin gene-related peptide and substance P in the pathogenesis of dialysis headache

IF 1.2 4区医学 Q3 UROLOGY & NEPHROLOGY Hemodialysis International Pub Date : 2023-10-18 DOI:10.1111/hdi.13120

Gizem Gürsoy, Serhat Karadağ, Şennur Köse, Tamer Şakacı, Sibel Yücel Koçak, Yasemin Erdoğan Döventaş, Ayla Çulha Oktar, Muhammet Duran Bayar

{"title":"The role of calcitonin gene-related peptide and substance P in the pathogenesis of dialysis headache","authors":"Gizem Gürsoy, Serhat Karadağ, Şennur Köse, Tamer Şakacı, Sibel Yücel Koçak, Yasemin Erdoğan Döventaş, Ayla Çulha Oktar, Muhammet Duran Bayar","doi":"10.1111/hdi.13120","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Aim</h3>\n \n <p>The present study aims to establish the role of serum CGRP and SP levels in the disease pathophysiology in patients with dialysis headache not accompanied by primary or secondary headaches, and also whether there is a correlation between these vasoactive peptides and the severity of headache.</p>\n </section>\n \n <section>\n \n <h3> Method</h3>\n \n <p>This study was designed as prospective and multicenter. A total of 30 dialysis headache patients and 30 patients without headache as the control group in the Nephrology outpatient clinics which implement similar dialysis procedures were included in the study. Blood samples were taken from all the patients before hemodialysis, and post-hemodialysis samples were collected. CGRP and SP contents in serum samples were measured using the ELISA method with detection kits.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>A total of 60 patients were included in the study with 17 female and 13 male patients in the dialysis headache group and 18 female and 12 male patients in the control group, and there were no significant differences in sex and age between the groups. CGRP levels in the headache group were found to be significantly higher compared with the control group both before and after hemodialysis. Furthermore, pre-hemodialysis CGRP levels were significantly higher than post-hemodialysis CGRP levels in both the headache and control groups. Serum SP levels in the headache group were found to be higher compared with the control group both before and after hemodialysis, there was no significant difference between the groups. Even though SP levels in both groups decreased after hemodialysis, there was again no significant difference between the groups. No correlation was found between the patients' severity of headache and serum CGRP and SP levels.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>This study concludes that CGRP and SP, even though the latter is not statistically significant, play a role in the pathophysiology of the dialysis headache, and further studies with a larger and more specific patient population may reveal the relationship between the neuropeptides and dialysis headache more clearly.</p>\n </section>\n </div>","PeriodicalId":12815,"journal":{"name":"Hemodialysis International","volume":null,"pages":null},"PeriodicalIF":1.2000,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Hemodialysis International","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/hdi.13120","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Aim

The present study aims to establish the role of serum CGRP and SP levels in the disease pathophysiology in patients with dialysis headache not accompanied by primary or secondary headaches, and also whether there is a correlation between these vasoactive peptides and the severity of headache.

Method

This study was designed as prospective and multicenter. A total of 30 dialysis headache patients and 30 patients without headache as the control group in the Nephrology outpatient clinics which implement similar dialysis procedures were included in the study. Blood samples were taken from all the patients before hemodialysis, and post-hemodialysis samples were collected. CGRP and SP contents in serum samples were measured using the ELISA method with detection kits.

Results

A total of 60 patients were included in the study with 17 female and 13 male patients in the dialysis headache group and 18 female and 12 male patients in the control group, and there were no significant differences in sex and age between the groups. CGRP levels in the headache group were found to be significantly higher compared with the control group both before and after hemodialysis. Furthermore, pre-hemodialysis CGRP levels were significantly higher than post-hemodialysis CGRP levels in both the headache and control groups. Serum SP levels in the headache group were found to be higher compared with the control group both before and after hemodialysis, there was no significant difference between the groups. Even though SP levels in both groups decreased after hemodialysis, there was again no significant difference between the groups. No correlation was found between the patients' severity of headache and serum CGRP and SP levels.

Conclusion

This study concludes that CGRP and SP, even though the latter is not statistically significant, play a role in the pathophysiology of the dialysis headache, and further studies with a larger and more specific patient population may reveal the relationship between the neuropeptides and dialysis headache more clearly.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

降钙素基因相关肽和P物质在透析性头痛发病机制中的作用。

目的：本研究旨在确定血清CGRP和SP水平在不伴有原发性或继发性头痛的透析性头痛患者的疾病病理生理学中的作用，以及这些血管活性肽与头痛的严重程度之间是否存在相关性。方法：本研究为前瞻性多中心研究。在实施类似透析程序的肾病门诊，共有30名透析头痛患者和30名无头痛患者作为对照组纳入研究。血液透析前采集所有患者的血样，血液透析后采集血样。用ELISA法和检测试剂盒测定血清中CGRP和SP的含量。结果：共有60名患者被纳入研究，透析头痛组17名女性和13名男性患者，对照组18名女性和12名男性患者。两组之间的性别和年龄没有显著差异。在血液透析前后，头痛组的CGRP水平均显著高于对照组。此外，头痛组和对照组血液透析前CGRP水平均显著高于血液透析后CGRP水平。头痛组血液透析前后血清SP水平均高于对照组，两组间无显著差异。尽管血液透析后两组的SP水平都有所下降，但两组之间再次没有显著差异。患者头痛的严重程度与血清CGRP和SP水平之间没有相关性。结论：本研究得出结论，CGRP和SP在透析性头痛的病理生理学中发挥作用，尽管后者没有统计学意义，但对更大、更具体的患者群体进行进一步研究可能会更清楚地揭示神经肽与透析性头痛之间的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Hemodialysis International UROLOGY & NEPHROLOGY-

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Hemodialysis International was originally an annual publication containing the Proceedings of the International Symposium on Hemodialysis held in conjunction with the Annual Dialysis Conference. Since 2003, Hemodialysis International is published quarterly and contains original papers on clinical and experimental topics related to dialysis in addition to the Annual Dialysis Conference supplement. This journal is a must-have for nephrologists, nurses, and technicians worldwide. Quarterly issues of Hemodialysis International are included with your membership to the International Society for Hemodialysis. The journal contains original articles, review articles, and commentary to keep readers completely updated in the field of hemodialysis. Edited by international and multidisciplinary experts, Hemodialysis International disseminates critical information in the field.