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The effect of implementing a dialysis start unit on modality decision among patients with unplanned start kidney replacement therapy 实施透析起始单元对计划外开始肾脏替代治疗的患者决定透析方式的影响。
IF 1.2 4区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2024-06-27 DOI: 10.1111/hdi.13165
Shira Goldman, Joanne M. Bargman, Charmaine E. Lok, Anna Gozdzik, Jeffrey Perl, Christopher T. Chan

Introduction

Many individuals start dialysis in an acute setting with suboptimal pre-dialysis education. These individuals are often treated with central venous catheter insertion and initiation of in-center hemodialysis and only a minority will transfer to a home-based therapy. The dialysis start unit is a program performing in-center hemodialysis in a separate space while providing support and education on chronic kidney disease and treatment options in the initial weeks of kidney replacement therapy. We aimed to assess the uptake of home dialysis therapies between 2013 and 2021 among patients who started acute inpatient hemodialysis at University Health Network, Toronto and underwent dialysis at the dialysis start unit.

Methods

This is a retrospective observational cohort study based on prospectively collected data. Patients' demographics were obtained from electronic charts. In the dialysis start unit, all patients received dialysis modality education by a nurse educator, dedicated home dialysis nurses, and the allied health care team.

Findings

During 2013–2021, 122 patients were dialyzed in the dialysis start unit and included in the study. Among those patients, 68 patients ultimately chose home dialysis (57 peritoneal dialysis and 11 home hemodialysis). Fifty-four patients continued in-center hemodialysis. Patients adopting home dialysis were less likely to have diabetes and hypertension as the etiology of kidney failure and more likely to have glomerulonephritis or vasculitis.

Discussion

Dialysis modality education is implementable in advanced chronic kidney disease. Individualized education and care after unplanned start dialysis can potentially enhance home dialysis choice and utilization.

导言:许多人在急性透析环境中开始透析时,透析前的教育并不理想。这些患者通常需要插入中心静脉导管并开始中心内血液透析,只有少数患者会转入家庭透析治疗。透析启动单元是一个在独立空间内进行中心内血液透析的项目,同时在肾脏替代疗法的最初几周提供有关慢性肾脏病和治疗方案的支持和教育。我们的目的是评估2013年至2021年期间在多伦多大学健康网络开始急性住院血液透析并在透析起始单位接受透析治疗的患者中接受家庭透析疗法的情况:这是一项基于前瞻性收集数据的回顾性观察队列研究。患者的人口统计数据来自电子病历。在透析起始单位,所有患者都接受了由护士教育者、专职家庭透析护士和专职医疗团队提供的透析方式教育:2013-2021年间,共有122名患者在透析起始单位接受了透析,并被纳入研究范围。其中,68 名患者最终选择了家庭透析(57 名腹膜透析患者和 11 名家庭血液透析患者)。54名患者继续在中心进行血液透析。采用家庭透析的患者中,肾衰竭的病因是糖尿病和高血压的可能性较小,而肾小球肾炎或血管炎的可能性较大:讨论:透析方式教育可在晚期慢性肾脏病患者中实施。讨论:透析方式教育在晚期慢性肾脏病中是可以实施的,计划外开始透析后的个性化教育和护理有可能提高家庭透析的选择和利用率。
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引用次数: 0
Impact of specialized renal technologists on optimizing delivery of continuous kidney replacement therapy in critical care areas a retrospective study 专业肾脏技师对优化重症监护领域持续肾脏替代疗法的影响回顾性研究。
IF 1.2 4区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2024-06-27 DOI: 10.1111/hdi.13167
Noha Abou Khater, Ahmed Adel Sadeq, Dima Tareq Al Absi, Mecit Can Emre Simsekler, Islam Mohamed Khattab, Ehab Aboualazayem Shalaby, Rawan AbuKhater, Deanne Tomie Kashiwagi, Christian Andras, Andrea Molesi, Fahad Omar, Mezher Abbas, Mohammed Sifar Pirayil, Siddiq Anwar

Background

Continuous renal replacement therapy (CKRT) is delivered to some of the most critically ill patients in hospitals. This therapy is expensive and requires coordination of multidisciplinary teams to ensure the prescribed dose is delivered. With increased demands on the critical care nursing staff and increased complexities of patients admitted to critical care units, we evaluated the role of specialized renal technologists in ensuring the prescribed dose is delivered. Therefore, the aim of this study is to investigate the impact of supporting intensive care unit nurses with specialized renal technologists on optimizing efficiency of CKRT sessions in the United Arab Emirates.

Methods

This is a retrospective study that compared critically ill patients on CKRT overseen by specialized renal technologists versus who are non-covered in the year 2021.

Results

A total of 331 sessions on 158 patients were included in the study. The mean filter life was longer in specialized renal technologists—covered patients compared to the non-covered group (66 vs. 59 h, p = 0.019). After adjustment by multiple regression analysis for risk factors (i.e., age, gender, mechanical ventilation, sepsis, mean arterial pressure, vasopressors, and SOFA) that may affect CKRT machines' filter life, presence of a specialized renal technologists resulted in significantly longer filter life (co-efficient 0.129; CI 95% 1.080, 11.970; p-value: 0.019).

Conclusion

Our study suggests that specialized renal technologists play a vital role in prolonging CKRT machine's filter life span and optimizing CKRT machine's efficiency. Further research should focus on other potential benefits of having specialized renal technologists performing CKRT sessions, and to confirm the finding of this study. Additionally, a cost–benefit analysis could be conducted to determine the economic impact of having specialized teams performing CKRT.

背景:连续性肾脏替代疗法(CKRT)是为医院中一些重症患者提供的治疗方法。这种疗法费用昂贵,而且需要多学科团队的协调,以确保达到规定剂量。随着对重症监护护理人员要求的提高以及重症监护病房收治病人复杂性的增加,我们对专业肾脏技师在确保提供规定剂量方面的作用进行了评估。因此,本研究旨在调查在阿拉伯联合酋长国,由专业肾脏技师为重症监护病房护士提供支持对优化 CKRT 治疗效率的影响:这是一项回顾性研究,对 2021 年接受专业肾脏技师监督的 CKRT 重症患者与未接受监督的重症患者进行了比较:研究共对 158 名患者进行了 331 次治疗。与非医保组相比,由专业肾脏技师监督的患者的平均滤过时间更长(66 小时对 59 小时,P = 0.019)。通过多元回归分析对可能影响 CKRT 机过滤器寿命的风险因素(即年龄、性别、机械通气、脓毒症、平均动脉压、血管加压剂和 SOFA)进行调整后,专业肾脏技师的存在显著延长了过滤器的寿命(系数 0.129;CI 95% 1.080,11.970;P 值:0.019):我们的研究表明,专业肾脏技师在延长 CKRT 机器过滤器寿命和优化 CKRT 机器效率方面发挥着重要作用。进一步的研究应关注由专业肾脏技师进行 CKRT 治疗的其他潜在益处,并证实本研究的结论。此外,还可以进行成本效益分析,以确定由专业团队执行 CKRT 的经济影响。
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引用次数: 0
Metal phosphide poisoning in a disaster-stricken area. Can early hemodialysis improve outcomes? 受灾地区的磷化氢金属中毒。早期血液透析能否改善预后?
IF 1.2 4区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2024-06-27 DOI: 10.1111/hdi.13168
Najjar Abdo, Sekkarie Mohamed, Valerie Luyckx, Alabdullah Mohammad, Sulaiman Abdu el Rahman, Kuhn Christine, Jetter Alexander, Hajj Nasan Khaled, Murad Lina, Rifai Ahmad Oussama, Sami Alasfar, AlhajHusain Ahmad

Background

Phosphide metal poisoning results in tens of thousands of fatalities per year worldwide. The mortality in critically ill patients often exceeds 50%. The available treatment is supportive and there is no antidote. Dialysis is recommended to treat advanced complications but has not been prescribed early in the process. In this study we report our experience in using dialysis in the early hours of presentation of the patients and suggest it can favorably improve the prognosis. We also draw attention to the risk of suicide under conditions of chronic conflict such as those in northwestern Syria, and to the lack of necessary mental health support for patients after suicide attempts.

Methods

Retrospective review of records of patients poisoned with aluminum phosphide and admitted to critical care facilities in northwestern Syria between July 2022 and June 2023.

Results

During the observation period 16 cases were encountered. Suicide was the reason of the poisoning in 15 patients, the median patient age was 18 years and over two thirds of the patients were female. Early dialysis was used in 11 patients who were critically ill and their mortality rate was 18%.

Conclusions

Phosphide metal poisoning is common in the disasters stricken area of northwestern Syria. Most cases are suicidal and impact young females. Early dialytic interventions may favorably impact the outcomes.

背景:全世界每年有数万人死于磷化氢金属中毒。重症患者的死亡率往往超过 50%。现有的治疗是支持性的,没有解毒剂。建议采用透析治疗晚期并发症,但在治疗过程的早期并不采用这种方法。在本研究中,我们报告了在患者发病早期使用透析的经验,并建议透析可有效改善预后。我们还提请大家注意在叙利亚西北部等长期冲突条件下的自杀风险,以及自杀未遂患者缺乏必要的心理健康支持的问题:方法:回顾性审查 2022 年 7 月至 2023 年 6 月期间叙利亚西北部重症监护机构收治的磷化铝中毒患者的记录:结果:观察期间共发现16例中毒病例。15 名患者的中毒原因是自杀,患者年龄中位数为 18 岁,超过三分之二的患者为女性。11名病情危重的患者接受了早期透析,死亡率为18%:结论:磷化氢金属中毒在叙利亚西北部受灾地区很常见。大多数病例为自杀,且多为年轻女性。早期透析干预可能会对治疗效果产生有利影响。
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引用次数: 0
Effects of a medium cut-off dialyzer on inflammation and cardiac and vascular function in hemodialysis patients with heart failure 中截流透析器对心力衰竭血液透析患者的炎症、心脏和血管功能的影响。
IF 1.2 4区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2024-06-25 DOI: 10.1111/hdi.13166
Irem Ozarli, Hacı Hasan Yeter, Yusuf Ziya Sener, Cebrail Cebrailov, Tolga Yildirim, Rahmi Yilmaz

Introduction

Expanded hemodialysis (HDx) could provide clearance of larger middle-molecule uremic toxins. We compared the effect of hemodialysis with medium cut-off membranes and high-flux (HFHD) membranes regarding changes in inflammation and vascular and left ventricular function.

Methods

This was a single-center, prospective, parallel-group comparative study. Patients were divided into two groups (HDx: 25 patients and HFHD: 26 patients). All measurements were performed at baseline and 12 weeks. Serum c-reactive protein, interkelukin-18, pentraxin-3, β-2 microglobulin, and brain natriuretic peptide were measured. We used pulse wave velocity and augmentation index to assess arterial stiffness and echocardiography to evaluate left and right ventricular function.

Findings

We enrolled 51 patients. Although serum c-reactive protein, interkelukin-18, pentraxin 3, and β-2 microglobulin were significantly decreased in the HDx group (p = 0.02, p < 0.001, p = 0.002, and p = 0.02, respectively), there was no significant change in HFHD group at 12th week. Serum c-reactive protein and interkelukin-18were significantly lower in the HDx group compared to the HFHD group in the 12th week (p = 0.007 and p = 0.03, respectively). We observed a significant decrease in pulse wave velocity in the HDx group at the end of the study (p = 0.03). Although there was no significant change in pulse wave velocity in the HFHD group, pulse wave velocity was similar between the HDx and HFHD groups in the 12th week. We detected a significant decrease in the mean isovolumetric relaxation time in the HDx group (p = 0.006). However, there was no significant difference in isovolumetric relaxation time between the HDx and HFHD groups in the 12th week.

Discussion

HDx provides better clearance of middle molecular uremic toxins and inflammatory biomarkers, and it may be associated with better central hemodynamic parameters and diastolic functions.

简介:扩大血液透析(HDx)可清除较大的中等分子尿毒症毒素。我们比较了使用中截流膜和高通量(HFHD)膜进行血液透析对炎症、血管和左心室功能变化的影响:这是一项单中心、前瞻性、平行组比较研究。患者分为两组(HDx:25 名患者;HFHD:26 名患者)。所有测量均在基线和 12 周时进行。我们测量了血清 c 反应蛋白、白介素-18、五肽-3、β-2 微球蛋白和脑钠肽。我们用脉搏波速度和增强指数来评估动脉僵化,用超声心动图来评估左心室和右心室的功能:我们共招募了 51 名患者。虽然 HDx 组的血清 c 反应蛋白、白介素-18、五肽 3 和 β-2 微球蛋白显著下降(p = 0.02,p 讨论),但 HDx 组的血清 c 反应蛋白、白介素-18、五肽 3 和 β-2 微球蛋白显著下降(p = 0.02,p 讨论):HDx 能更好地清除中分子尿毒症毒素和炎症生物标志物,而且可能与更好的中心血流动力学参数和舒张功能有关。
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引用次数: 0
The effects of mandala coloring on fatigue, psychological well-being, and coping with stress in patients receiving hemodialysis treatment 曼陀罗涂色对血液透析患者疲劳、心理健康和应对压力的影响。
IF 1.2 4区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2024-06-19 DOI: 10.1111/hdi.13163
Zülfünaz Özer, Gülcan Bahçecioğlu Turan, Mine Uyman, Mukadder Mollaoğlu

Background

Hemodialysis is an important health problem that negatively affects psychosocial status and support systems. Through practices such as mandala coloring, individuals transfer the unknowns they experience to the outside and make them visible. This study was conducted to examine the effects of mandala coloring on fatigue, psychological well-being, and factors associate with coping with stress in patients receiving hemodialysis treatment.

Methods

The design was a prospective, parallel-group controlled trial. The study was conducted in the dialysis unit of a university hospital in eastern Turkey between April 4 and October 31, 2022, with a total of 60 patients, 30 in the intervention group, and 30 in the control group. The patients in the intervention group colored mandala once a week for 2 h, for a total of 8 weeks. The data were collected face-to-face using a patient information form, a Fatigue Severity Scale, a Psychological Well-Being Scale, and a Ways of Coping Questionnaire.

Results

There were improvements in fatigue severity and psychological well-being over the 8-week study period in both the intervention and control groups. Scores were similar at baseline in the control and intervention groups, but better in the intervention groups compared to controls at 4 and 8 weeks for both metrics (p < 0001). Five factors from the Ways of Coping Questionnaire (self-confident approach, optimistic approach, seeking social support, helpless approach, and submissive approach) each improved during the 8-week period in the intervention group (p < 0.001). Three of these five factors improved in the control group as well. Scores for each of the five coping factors were better in the intervention group compared to controls at 4 and 8 weeks (p < 0.001).

Conclusion

Mandala coloring improved fatigue and psychological well-being and was associated with improved patient coping strategies.

背景:血液透析是一个重要的健康问题,对社会心理状态和支持系统造成负面影响。通过曼陀罗涂色等实践,个人将其经历的未知转移到外部,并使其可见。本研究旨在探讨曼陀罗涂色对接受血液透析治疗的患者的疲劳、心理健康以及应对压力的相关因素的影响:设计为前瞻性平行组对照试验。研究于 2022 年 4 月 4 日至 10 月 31 日在土耳其东部一所大学医院的透析室进行,共有 60 名患者参加,其中干预组和对照组各 30 人。干预组患者每周为曼陀罗上色一次,每次 2 小时,共持续 8 周。通过患者信息表、疲劳严重程度量表、心理健康量表和应对方式问卷面对面收集数据:结果:在为期 8 周的研究期间,干预组和对照组的疲劳严重程度和心理健康都有所改善。对照组和干预组的基线得分相似,但在 4 周和 8 周时,干预组的两项指标均优于对照组(p 结论:曼陀罗涂色改善了疲劳程度和心理健康:曼陀罗涂色改善了疲劳和心理健康,并与患者应对策略的改善有关。
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引用次数: 0
The knowledge, attitudes, and practices of arteriovenous access assessment among hemodialysis nurses: A multicenter cross-sectional survey 血液透析护士对动静脉通路评估的认识、态度和实践:多中心横断面调查。
IF 1.2 4区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2024-05-27 DOI: 10.1111/hdi.13160
Jingying Chen, Jinghua Lu, Xia Fu, Hongzhen Zhou

Introduction

Hemodialysis nurses' cannulation technique, monitoring, and management methods can affect patients' vascular access longevity. An arteriovenous access assessment comprises a medical history and vascular assessment through physical examination and surveillance. However, further exploration is needed to fully understand hemodialysis nurses' knowledge, attitudes, and practices (KAP) in this area.

Methods

Between June and July 2023, we recruited hemodialysis nurses from 21 cities in Guangdong Province using a convenience sampling method. Four questionnaires—the General Data Questionnaire, the KAP Scale of Arteriovenous Access Assessment among Hemodialysis Nurses, the Utrecht Work Engagement Scale, and the NASA Task Load Index—were utilized for data collection through the Questionnaire Star platform.

Findings

Of the 530 hemodialysis nurses participating in the study, 458 (86.4%) had a valid response. The participants demonstrated moderate knowledge and practice levels regarding arteriovenous access assessment and exhibited positive attitudes. We identified several factors related to arteriovenous access assessment that predict KAP in hemodialysis nurses. These factors included years of experience as a hemodialysis nurse, whether a nurse's knowledge of physical examination was sufficient to meet clinical needs, whether a nurse had received training in performing physical examination, whether a nurse's department regularly checked the quality of physical examination, and nurses' levels of work engagement and mental workload. All factors explained 32.4% of the variance in participants' KAP regarding arteriovenous access assessment.

Discussion

Improving hemodialysis nurses' assessment of arteriovenous access is crucial to ensure optimal patient care. Dialysis center managers and educators should prioritize understanding hemodialysis nurses' KAP of arteriovenous access assessment and any factors influencing these areas.

导言:血液透析护士的插管技术、监测和管理方法会影响患者血管通路的寿命。动静脉通路评估包括病史以及通过体格检查和监测进行的血管评估。然而,要充分了解血液透析护士在这方面的知识、态度和实践(KAP),还需要进一步的探索:方法:2023 年 6 月至 7 月期间,我们采用便利抽样法招募了广东省 21 个城市的血液透析护士。通过问卷星平台,利用四份问卷--一般数据问卷、血液透析护士动静脉通路评估 KAP 量表、乌得勒支工作参与量表和 NASA 任务负荷指数进行数据收集:在参与研究的 530 名血液透析护士中,458 人(86.4%)做出了有效回答。参与者在动静脉通路评估方面的知识和实践水平适中,并表现出积极的态度。我们发现了几个与动静脉通路评估相关的因素,这些因素可预测血液透析护士的 KAP。这些因素包括血液透析护士的工作年限、护士的体格检查知识是否足以满足临床需要、护士是否接受过体格检查培训、护士所在科室是否定期检查体格检查质量以及护士的工作投入程度和脑力劳动负荷。所有因素解释了参与者在动静脉通路评估方面的 KAP 差异的 32.4%:讨论:改善血液透析护士对动静脉通路的评估对确保最佳患者护理至关重要。透析中心的管理者和教育者应优先了解血液透析护士对动静脉通路评估的 KAP 以及影响这些方面的任何因素。
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引用次数: 0
Hemodynamic effects of low versus high dialysate bicarbonate concentration in hemodialysis patients 血液透析患者透析液碳酸氢盐浓度过低与过高对血液动力学的影响。
IF 1.2 4区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2024-05-27 DOI: 10.1111/hdi.13162
Jonas Schandorph Kaalund Jensen, Ina Hunnerup Jørgensen, Niels Henrik Buus, Jens Dam Jensen, Christian Daugaard Peters

Introduction

Hemodialysis treatment using standard dialysate bicarbonate concentrations cause transient metabolic alkalosis possibly associated with hemodynamic instability. The aim of this study was to perform a detailed comparison of high and low dialysate bicarbonate in terms of blood pressure, intradialytic hemodynamic parameters, orthostatic blood pressure, and electrolytes.

Methods

Fifteen hemodialysis patients were examined in a single-blind, randomized, controlled, crossover study. Participants underwent a 4-h hemodialysis session with dialysate bicarbonate concentration of 30 or 38 mmol/L with 1 week between interventions. Blood pressure was monitored throughout hemodialysis, while cardiac output, total peripheral resistance, stroke volume, and central blood volume were assessed with ultrasound dilution technique (Transonic). Orthostatic blood pressure was measured pre- and post-hemodialysis.

Findings

With similar ultrafiltration (UF) volume (2.6 L), systolic blood pressure (SBP) tended to decrease more during high dialysate bicarbonate compared to low dialysate bicarbonate; the mean (95% confidence interval) between treatment differences in SBP were: 8 (−4; 20) mmHg (end of hemodialysis) and 7 (0; 15) mmHg (post-hemodialysis). Stroke volume decreased whereas total peripheral resistance increased significantly more during high dialysate bicarbonate compared to low dialysate bicarbonate with mean between treatment differences: Stroke volume: 12 (1; 23) mL; Total peripheral resistance: −2.9 (−5.3; −0.5) mmHg/(L/min). Cardiac output tended to decrease more with high dialysate bicarbonate compared to low dialysate bicarbonate with mean between treatment difference 0.7 (0.0; 1.4) L/min. High dialysate bicarbonate caused alkalosis, hypocalcemia, and lower plasma potassium, whereas patients remained normocalcemic with normal pH during low dialysate bicarbonate. Orthostatic blood pressure response after dialysis did not differ significantly.

Discussion

The use of high dialysate bicarbonate compared to low dialysate bicarbonate was associated with hypocalcemia, alkalosis, and a more pronounced hypokalemia. During hemodialysis with UF, a better preservation of blood pressure, stroke volume, and cardiac output may be achieved with low dialysate bicarbonate compared to high dialysate bicarbonate.

导言:使用标准透析液碳酸氢盐浓度进行血液透析治疗会导致短暂的代谢性碱中毒,可能与血液动力学不稳定有关。本研究旨在对高浓度和低浓度透析液碳酸氢盐在血压、透析内血液动力学参数、正压和电解质方面进行详细比较:在一项单盲、随机对照、交叉研究中,15 名血液透析患者接受了检查。参与者在透析液碳酸氢盐浓度为 30 或 38 mmol/L 的条件下进行 4 小时血液透析,两次透析间隔一周。血液透析过程中全程监测血压,同时使用超声稀释技术(Transonic)评估心输出量、总外周阻力、每搏量和中心血容量。血液透析前和透析后测量静动脉血压:在超滤量(2.6 升)相似的情况下,与低碳酸氢盐透析液相比,高碳酸氢盐透析液透析时收缩压(SBP)的下降幅度更大;SBP 的平均值(95% 置信区间)在不同治疗间的差异为:8(-4;20)毫米汞柱:8(-4;20)毫米汞柱(血液透析结束时)和7(0;15)毫米汞柱(血液透析后)。与低碳酸氢盐透析相比,在高碳酸氢盐透析期间,卒中量明显减少,而总外周阻力明显增加,治疗间平均差异为平均治疗差异为:卒中量:12 (1; 23) mL;总外周阻力:-2.9 (-5.3; -0.5) mmHg/(L/min)。与低碳酸氢盐透析液相比,高碳酸氢盐透析液的心输出量下降幅度更大,治疗间平均差异为 0.7 (0.0; 1.4) 升/分钟。高浓度透析液碳酸氢盐会导致碱中毒、低钙血症和血浆钾降低,而低浓度透析液碳酸氢盐则会使患者保持正常钙血症和正常 pH 值。讨论:讨论:与低碳酸氢盐透析相比,使用高碳酸氢盐透析与低钙血症、碱中毒和更明显的低钾血症有关。在使用超滤的血液透析过程中,低碳酸氢盐透析液比高碳酸氢盐透析液能更好地保持血压、每搏量和心输出量。
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引用次数: 0
Application of therapeutic ultrasonic waves across the dialyzer membrane: A pilot study on the impact on dialyzer clearance and safety 在透析器膜上应用治疗性超声波:关于透析器清除率和安全性影响的试点研究。
IF 1.2 4区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2024-05-24 DOI: 10.1111/hdi.13161
Girish Namagondlu Seetharamaiah, Limesh Marisiddappa, Shashank Dhareshwar, Savitha Rani, Nikhil Das

Introduction

Progressive clogging of the dialyzer membrane during hemodialysis can compromise solute removal efficiency. Existing solutions fall short in addressing intradialytic reduction of dialyzer clearance. This pilot study aims to assess the impact and safety of applying therapeutic ultrasonic waves to dialyzers for mitigating intradialytic clogging.

Methods

In this pilot study, 15 stable maintenance hemodialysis patients (12 males and 3 females) were enrolled. Each patient served as their own control. They underwent one session of hemodialysis with the application of therapeutic ultrasonic waves (Ultrasonic session) and were crossed-over to a second session without the use of ultrasonic waves (Control session). All the study sessions operated at a fixed dialysate flow rate of 500 mL/min and a blood flow rate of 250 or 300 mL/min. The adequacy of dialysis achieved during each session was monitored using Online Clearance Monitoring of the dialysis machines, and clearance K values, varying between 135 and 209 mL/min, were recorded, and plotted. A direct comparison between Control and Ultrasonic sessions was performed to assess the impact and safety of using ultrasonic waves during hemodialysis.

Findings

The mean percentage decline in dialyzer clearance values was 4.41% for Ultrasonic sessions (SD: 5.3) and 12.69% for Control sessions (SD: 6.35) (p-value <0.001). This indicates that the application of ultrasonic waves reduced the decline in clearance values. The mean differences of the blood component parameters were comparable between both Ultrasonic sessions and Control sessions, suggesting the safety of utilizing ultrasonic waves during dialysis. Microscopic membrane analysis corroborated the safety.

Discussion

Intradialytic clogging of dialyzer membranes is a significant problem that can cause dialysis inadequacy. Our study tackles this issue by introducing therapeutic ultrasonic waves to improve dialyzer clearance during hemodialysis sessions in patients.

简介血液透析过程中透析器膜的逐渐堵塞会影响溶质清除效率。现有的解决方案无法解决透析器内清除率降低的问题。本试验研究旨在评估在透析器上应用治疗性超声波以减轻透析器内堵塞的影响和安全性:在这项试验性研究中,共招募了 15 名稳定的维持性血液透析患者(12 名男性和 3 名女性)。每位患者都是自己的对照组。他们接受了一次应用治疗性超声波的血液透析治疗(超声波治疗),并交叉接受了第二次不使用超声波的血液透析治疗(对照治疗)。所有研究时段的透析液流速固定为 500 毫升/分钟,血流量为 250 或 300 毫升/分钟。利用透析机的在线清除率监测系统对每次透析过程中的透析充分性进行监测,记录并绘制清除率 K 值(介于 135 至 209 毫升/分钟之间)。对对照组和超声波组进行直接比较,以评估在血液透析过程中使用超声波的影响和安全性:结果:超声波透析的透析器清除率平均下降了 4.41%(SD:5.3),而对照组下降了 12.69%(SD:6.35)(P 值讨论):透析膜的椎管内堵塞是导致透析不足的一个重要问题。我们的研究通过引入治疗性超声波来改善患者血液透析过程中透析器的清除率,从而解决了这一问题。
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引用次数: 0
Relationship between altered taste and smell with malnutrition among hemodialysis patients 血液透析患者的味觉和嗅觉改变与营养不良之间的关系。
IF 1.2 4区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2024-05-23 DOI: 10.1111/hdi.13158
İlknur Özkan, Seçil Taylan, Yücel Kurt

Introduction

Alterations in taste and smell are among the most distressing symptoms experienced by haemodialysis patients. There is limited research on the relationship between these two symptoms and malnutrition in haemodialysis patients. This study aimed to investigate alterations in taste and smell in hemodialysis patients and their relationship with malnutrition.

Methods

This cross-sectional study was carried out with 149 hemodialysis patients at the dialysis centers of three state hospitals. The Taste and Smell Dysfunction Questionnaire was used to assess the changes in patients' taste and smell, and the Prognostic Nutritional Index (PNI), as well as the Controlling Nutritional Status (CONUT) tool, were utilized to evaluate their nutritional status.

Findings

A substantial percentage (45.6%) of patients reported an altered sense of smell, and 40.2% reported an altered sense of taste. The aspect of taste that was most abnormal was bitterness (46.7%); 53.0% of the patients were at moderate risk of malnutrition by PNI score, and 14.8% were categorized as malnourished by CONUT score. Malnutrition was related to dialysis vintage: a 1-year increase in vintage was associated with an increased risk of malnutrition (OR: 1.17, 95% CI 1.02–1.32, p < 0.001). Altered taste was associated with malnutrition: one-unit increase in the standard deviation of the taste subdimension score was associated with a relative risk of malnutrition (OR: 6.89, 95% CI 1.67–28.39, p < 0.001). A one-unit increase in the standard deviation of the smell subdimension was associated with relative risk of malnutrition (OR: 1.35, 95% CI 1.10–1.64, p < 0.001).

Discussion

Malnutrition was found in a significantpercentage of hemodialysis patients. Altered taste and smell and the durationof dialysis treatment were significantly associated with malnutrition scores It isrecommended that healthcare professionals regularly assess alterations in tasteand smell in hemodialysis patients, as these alterations may be associated withmalnutrition, and manage these alterations accordingly.

介绍:味觉和嗅觉的改变是血液透析患者最痛苦的症状之一。有关这两种症状与血液透析患者营养不良之间关系的研究十分有限。本研究旨在调查血液透析患者味觉和嗅觉的改变及其与营养不良的关系:这项横断面研究在三家国立医院的透析中心对 149 名血液透析患者进行了调查。采用味觉和嗅觉功能障碍问卷评估患者的味觉和嗅觉变化,并采用预后营养指数(PNI)和控制营养状况(CONUT)工具评估患者的营养状况:相当大比例(45.6%)的患者报告嗅觉发生了改变,40.2%的患者报告味觉发生了改变。根据 PNI 评分,53.0% 的患者面临中度营养不良风险,根据 CONUT 评分,14.8% 的患者被归类为营养不良。营养不良与透析年份有关:透析年份每增加一年,营养不良的风险就会增加(OR:1.17,95% CI 1.02-1.32,p 讨论):相当比例的血液透析患者存在营养不良。建议医护人员定期评估血液透析患者的味觉和嗅觉变化,因为这些变化可能与营养不良有关,并对这些变化进行相应的处理。
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引用次数: 0
Prevention and resolution of headaches occurring during hemodialysis treatment by supplemental oxygen 通过补充氧气预防和解决血液透析治疗期间出现的头痛。
IF 1.2 4区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2024-05-22 DOI: 10.1111/hdi.13159
Garrett B. Gianneschi, Jennine M. Michaud

A patient with end-stage renal disease experienced severe headaches exclusively during dialysis that were bilateral and throbbing with photophobia, weakness, and lightheadedness. The patient had no history of headaches, and dialysis was determined to be the cause of the severe headaches. More than 10 treatments were attempted without success. Headaches were successfully treated and prevented by addition of 100% oxygen (2 L via nasal cannula) for over 12 months without recurrence at time of publication. This case study indicates that oxygen therapy may be a valuable intervention for headaches during dialysis.

一名患有终末期肾病的患者在透析期间出现严重头痛,这种头痛是双侧性的,并伴有搏动性畏光、乏力和头晕。患者没有头痛病史,透析被确定为导致剧烈头痛的原因。患者尝试了十多种治疗方法,均未奏效。在发表本研究报告时,患者已使用 100% 氧气(通过鼻插管吸入 2 升)治疗头痛超过 12 个月,并且没有复发,从而成功地治疗和预防了头痛。本病例研究表明,氧疗可能是治疗透析期间头痛的一种有价值的干预措施。
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引用次数: 0
期刊
Hemodialysis International
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