Evaluation of the relationship between neonatal serum asprosin levels and anthropometric measurements in newborns of mothers with and without gestational diabetes mellitus.

Emine Esin Yalınbaş, Raziye Akcılar
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Abstract

Background: Asprosin is a newly identified adipokine that is expressed in the placenta. Its production is increased in women with gestational diabetes mellitus (GDM), and it is a factor related to insulin resistance. This study aimed to determine whether neonatal serum asprosin levels are associated with anthropometric characteristics of newborns born to mothers with and without GDM.

Methods: This study included 51 newborns of mothers with GDM (insulin-treated or diet-treated) and 55 control newborns with their mothers. In newborns, anthropometric parameters were measured, and the concentrations of asprosin were detected by ELISA. Maternal blood glucose levels, body weight, and length were measured and body mass index (BMI) was calculated.

Results: Serum asprosin levels were significantly higher and linked to a higher risk in the newborns of mothers with GDM compared with those of the control newborns (170.3 [132.6] vs. 91.4 [68.7] ng/mL, p < 0.001). Serum asprosin levels were negatively correlated with blood glucose concentrations (r = -0.282, p = 0.045) in the newborns of mothers with GDM and significantly positively correlated with birth weight (r = 0.315, p = 0.019) in the control newborns. Newborn serum asprosin levels were positively correlated with the glucose levels (r = 0.264, p = 0.006) of all mothers. In addition, newborns born to an insulin-treated mother with GDM had significantly higher birth weight and length than newborns born to a diet-treated mother with GDM (3262.9 vs. 3137 g, p = 0.032, and 49.7 vs. 49.2 cm, p = 0.05). Although asprosin levels were higher in newborns of mothers treated with insulin, these differences were not statistically significant. Mothers with GDM had high blood glucose levels (p = 0.032).

Conclusions: Serum levels of asprosin are increased and negatively correlated with glucose concentrations in newborns of mothers with GDM. Asprosin could be used as an early biomarker in newborns of GDM mothers.

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妊娠期糖尿病和非妊娠期糖尿病母亲新生儿血清asp松香水平与人体测量之间关系的评估。
背景:天冬氨酸是一种新发现的在胎盘中表达的脂肪因子。妊娠期糖尿病(GDM)妇女的胰岛素生成增加,是与胰岛素抵抗有关的因素。本研究旨在确定新生儿血清asprosin水平是否与患有和不患有GDM的母亲所生新生儿的人体测量特征有关。方法:本研究包括51例GDM(胰岛素治疗或饮食治疗)母亲的新生儿和55例对照新生儿及其母亲。在新生儿中,测量人体测量参数,并通过ELISA检测asp松香的浓度。测量母亲的血糖水平、体重和身长,并计算体重指数(BMI)。结果:与对照新生儿相比,患有GDM的母亲的新生儿血清asprosin水平显著更高,并与更高的风险相关(170.3[132.6]vs.91.4[68.7]ng/mL,p<0.001)对照组新生儿出生体重(r=0.315,p=0.019)。新生儿血清asprosin水平与所有母亲的血糖水平呈正相关(r=0.264,p=0.006)。此外,接受胰岛素治疗的GDM母亲所生的新生儿的出生体重和身长明显高于接受饮食治疗的GDM.(3262.9 vs.3137 g,p=0.032,49.7 vs.49.2 cm,p=0.05)。尽管接受胰岛素治疗母亲的新生儿asprosin水平较高,但这些差异无统计学意义。GDM母亲的血糖水平较高(p=0.032)。结论:GDM母亲新生儿的血清asprosin水平升高,且与血糖浓度呈负相关。天冬氨酸可以作为GDM母亲新生儿的早期生物标志物。
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