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Adaptation of the Problem Areas in Diabetes-Teen Scale into Turkish and examination of its psychometric properties: a validity and reliability study. 将 "青少年糖尿病问题领域量表 "改编成土耳其语并检验其心理测量特性:有效性和可靠性研究。
Pub Date : 2024-11-16 DOI: 10.24953/turkjpediatr.2024.4535
Seda Aybüke Sarı, Ezgi Agadayı, Nurullah Çelik, Seher Karahan, Ayça Kömürlüoğlu, Esra Döğer

Objective: Management of type 1 diabetes (T1DM) is quite challenging for both adolescents and their families. In this study, we aimed to translate the 14-item Problem Areas in Diabetes-Teen (PAID-T) scale, which measures variables that influence diabetes distress, to Turkish and investigate the Turkish version's reliability and validity.

Methods: One hundred and ninety-four adolescents with T1DM participated in the study. PAID-T and forms for sociodemographic and diabetes characteristics were used for data collection. The scale's content validity was checked using the Davis technique. Cronbach's α was used to analyze the scale's internal reliability and the test-retest for the scale's reliability. Exploratory factor analysis (EFA) was utilized to examine the factor structure. The fit of the scale was assessed using confirmatory factor analysis (CFA).

Results: Of the participants, 54.6% (n=106) were girls. The content validity index values of the scale items ranged between 0.86 and 1.0. The PAID-T scores of girls and boys were similar. No significant difference was found between PAID-T scores with sociodemographic data and diabetes characteristics (p>0.05). The test-retest correlation coefficient of the scale was found to be 0.952. The three-factor (emotional burden, family and friend distress, and regimen-specific distress) model identified in EFA explained 61.8% of the common variance. Fit analysis was performed using CFA for the three-factor model, which did not show adequate fit (x2/df = 2.402, GFI = 0.822, CFI = 0.815, NFI = 0.727, NNFI = 0.772, RMSEA = 0.118). The Cronbach α value of the scale was 0.864.

Conclusion: The Turkish version of the 14-item PAID-T showed moderate validity and strong reliability. Accordingly, it can be used as a reliable measurement tool to assess diabetes stress in adolescents with T1DM.

目的:1型糖尿病(T1DM)的管理对青少年及其家庭来说都是一项挑战。在这项研究中,我们旨在将测量影响糖尿病困扰的变量的 14 个项目的青少年糖尿病问题领域(PAID-T)量表翻译成土耳其语,并调查土耳其语版本的可靠性和有效性:194名患有T1DM的青少年参加了研究。收集数据时使用了 PAID-T 以及社会人口学和糖尿病特征表。量表的内容效度采用戴维斯技术进行检验。Cronbach's α 用于分析量表的内部信度,测试-再测用于分析量表的信度。探索性因子分析(EFA)用于研究因子结构。结果:在参与者中,54.6%(n=106)为女生。量表项目的内容效度指数介于 0.86 和 1.0 之间。女孩和男孩的 PAID-T 分数相似。PAID-T得分与社会人口学数据和糖尿病特征之间无明显差异(P>0.05)。量表的重测相关系数为 0.952。在 EFA 中确定的三因素(情绪负担、亲友困扰和特定疗程困扰)模型解释了 61.8% 的共同方差。使用 CFA 对三因素模型进行了拟合分析,结果显示拟合度不够(x2/df = 2.402,GFI = 0.822,CFI = 0.815,NFI = 0.727,NNFI = 0.772,RMSEA = 0.118)。量表的 Cronbach α 值为 0.864:14个项目的PAID-T土耳其版显示出中等程度的有效性和较高的可靠性。因此,该量表可作为一种可靠的测量工具,用于评估患有 T1DM 的青少年的糖尿病压力。
{"title":"Adaptation of the Problem Areas in Diabetes-Teen Scale into Turkish and examination of its psychometric properties: a validity and reliability study.","authors":"Seda Aybüke Sarı, Ezgi Agadayı, Nurullah Çelik, Seher Karahan, Ayça Kömürlüoğlu, Esra Döğer","doi":"10.24953/turkjpediatr.2024.4535","DOIUrl":"https://doi.org/10.24953/turkjpediatr.2024.4535","url":null,"abstract":"<p><strong>Objective: </strong>Management of type 1 diabetes (T1DM) is quite challenging for both adolescents and their families. In this study, we aimed to translate the 14-item Problem Areas in Diabetes-Teen (PAID-T) scale, which measures variables that influence diabetes distress, to Turkish and investigate the Turkish version's reliability and validity.</p><p><strong>Methods: </strong>One hundred and ninety-four adolescents with T1DM participated in the study. PAID-T and forms for sociodemographic and diabetes characteristics were used for data collection. The scale's content validity was checked using the Davis technique. Cronbach's α was used to analyze the scale's internal reliability and the test-retest for the scale's reliability. Exploratory factor analysis (EFA) was utilized to examine the factor structure. The fit of the scale was assessed using confirmatory factor analysis (CFA).</p><p><strong>Results: </strong>Of the participants, 54.6% (n=106) were girls. The content validity index values of the scale items ranged between 0.86 and 1.0. The PAID-T scores of girls and boys were similar. No significant difference was found between PAID-T scores with sociodemographic data and diabetes characteristics (p>0.05). The test-retest correlation coefficient of the scale was found to be 0.952. The three-factor (emotional burden, family and friend distress, and regimen-specific distress) model identified in EFA explained 61.8% of the common variance. Fit analysis was performed using CFA for the three-factor model, which did not show adequate fit (x2/df = 2.402, GFI = 0.822, CFI = 0.815, NFI = 0.727, NNFI = 0.772, RMSEA = 0.118). The Cronbach α value of the scale was 0.864.</p><p><strong>Conclusion: </strong>The Turkish version of the 14-item PAID-T showed moderate validity and strong reliability. Accordingly, it can be used as a reliable measurement tool to assess diabetes stress in adolescents with T1DM.</p>","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"66 5","pages":"588-598"},"PeriodicalIF":0.0,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142712361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sexually transmitted infections in sexually abused children: an audit project to implement PCR tests in a child advocacy center in Türkiye. 性虐待儿童中的性传播感染:在土耳其儿童维权中心实施 PCR 检测的审计项目。
Pub Date : 2024-11-16 DOI: 10.24953/turkjpediatr.2024.5188
Sıtkı Tıplamaz, Zeynep Ergenc, Murat Yaman, Tuğçe Kalaman, Elvan Sayın, Fatih Hitami Usluoğulları, Zeynep Arzu İlki, Nurver Ülger Toprak, Eda Kepenekli Kadayıfçı, Mehmet Akif İnanıcı

Background: Sexual abuse in children can sometimes result in sexually transmitted infections (STIs), which can serve as crucial forensic evidence. Although PCR methods are now accepted as the gold standard for STI screening, they have not yet widely replaced traditional culture methods in Türkiye. This study aims to assess the necessity of implementing PCR-based STI testing at Child Advocacy Centers in Türkiye, where such testing is not routinely available.

Methods: Conducted between February and November 2023, this study included children who presented to the Child Advocacy Center of Marmara University Pendik Training and Research Hospital. High-risk victims were identified based on criteria including a history of penetrative sexual abuse and factors such as multiple perpetrators or significant age disparity. Serological tests and genital swabs were collected and analyzed using both bacterial culture methods and a comprehensive STI PCR panel.

Results: The study included 20 victims, with a median age of 16 years. STI PCR testing detected pathogens in 19 out of 21 samples, including Chlamydia trachomatis (20%) and Neisseria gonorrhoeae (5%). In contrast, culture methods identified no sexually transmitted pathogens.

Conclusion: PCR testing demonstrated significantly higher sensitivity for detecting STIs compared to traditional bacterial culture methods, as expected. Implementing PCR-based STI testing in Child Advocacy Centers is an urgent and essential need for providing an accurate diagnosis and robust forensic evidence, enhancing the care and legal protection of sexually abused children.

背景:儿童性虐待有时会导致性传播感染 (STI),这可以作为重要的法医证据。尽管目前 PCR 方法已被公认为性传播感染筛查的黄金标准,但在土耳其,这种方法尚未广泛取代传统的培养方法。本研究旨在评估在土耳其的儿童咨询中心实施基于 PCR 的性传播感染检测的必要性:本研究于 2023 年 2 月至 11 月间进行,研究对象包括到马尔马拉大学彭迪克培训与研究医院儿童权益维护中心就诊的儿童。高风险受害者的识别标准包括插入式性虐待史和多个施害者或明显的年龄差异等因素。研究人员收集了血清检验和生殖器拭子,并使用细菌培养方法和全面的性传播感染 PCR 小组进行了分析:研究包括 20 名受害者,中位年龄为 16 岁。21 份样本中有 19 份通过 STI PCR 检测发现了病原体,包括沙眼衣原体(20%)和淋病奈瑟菌(5%)。相比之下,培养法没有发现性传播病原体:结论:与传统的细菌培养方法相比,PCR 检测对性传播感染的敏感性明显更高。在儿童咨询中心实施基于 PCR 的性传播感染检测是提供准确诊断和有力法医证据、加强对性侵犯儿童的关爱和法律保护的迫切和必要需求。
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引用次数: 0
Comprehensive analysis of genotypic and phenotypic characteristics of biotinidase deficiency patients in the eastern region of Türkiye. 综合分析图尔基耶东部地区生物素酶缺乏症患者的基因型和表型特征。
Pub Date : 2024-11-16 DOI: 10.24953/turkjpediatr.2024.5075
Kısmet Çıkı, Ceren Alavanda, Emine İpek Ceylan, Tijen Tanyalçın, Sebile Kılavuz

Background: Biotin is a water-soluble vitamin that plays a key role in carboxylation. The formation of free biotin is impaired in biotinidase deficiency (BD), resulting in impaired biotin-dependent carboxylase functions. Based on the percentage of residual serum enzyme activity, BD is classified as partial and profound.

Methods: Retrospective data including gender, age, parental consanguinity, family history, biotinidase activity analyses, type of deficiency (partial-profound), physical examination, treatment, and genotypes were evaluated in patients diagnosed with biotinidase deficiency in a single center in the eastern region of Türkiye. Patients whose biotinidase enzyme activity was below 30% with biallelic variants in the BTD gene were diagnosed as BD.

Results: A total of 302 patients were included in the study. Parental consanguinity was present in 135 (44.7%) of them. Two hundred eighty-six (94.7%) were diagnosed by neonatal screening, 14 (4.6%) by family screening and two (0.06%) by clinical symptoms. Ninety-two (30.5%) of the patients were followed-up with profound deficiency and 210 (69.5%) with partial deficiency. A total of 306 variants were detected. Twenty different variants (3 novel - 3 rare) and 31 different genotypes were detected. The 3 most frequently detected variants were c.410G>A (p.Arg137His; 47.3%), c.1270G>C (p.Asp424His; 29.7%), and c.38_44delGCGGCTGinsTCC (p.Cys13Phefs*36; 15.3%). The 3 most frequently identified genotypes were c.410G>A (p.Arg137His) / c.1270G>C (p.Asp424His) compound heterozygous (32.4%), c.410G>A (p.Arg137His) homozygous (24.8%), and c.38_44delGCGGCTGinsTCC (p.Cys13Phefs*36) / c.1270G>C (p.Asp424His) compound heterozygous (12.2%). Patients with c.410G>A (p.Arg137His) homozygous variant, c.38_44delGCGGCTGinsTCC (p.Cys13Phefs*36) homozygous variant and c.38_44delGCGGCTGinsTCC (p.Cys13Phefs*36) / c.410G>A (p.Arg137His) compound heterozygous variant were statistically significantly associated with profound deficiency. Compound heterozygosity of c.410G>A (p.Arg137His) / c.1270G>C (p.Asp424His) variants were significantly associated with partial deficiency.

Conclusions: The association between the BTD genotype and biochemical phenotype is not always consistent. Our study provides valuable data by adding variants with genotype-phenotype correlations to the literature and three novel variants, which can provide significant guidance in clinical follow-up.

背景:生物素是一种水溶性维生素,在羧化过程中起着关键作用。生物素缺乏症(BD)患者体内游离生物素的形成受阻,导致生物素依赖性羧化酶功能受损。根据残留血清酶活性的百分比,BD 可分为部分和深度两类:方法:在土耳其东部地区的一个中心对确诊为生物素酶缺乏症的患者进行回顾性数据评估,包括性别、年龄、父母血缘关系、家族史、生物素酶活性分析、缺乏症类型(部分-深度)、体格检查、治疗和基因型。生物素酶活性低于 30% 且 BTD 基因存在双倍变异的患者被诊断为生物素酶缺乏症:研究共纳入 302 名患者。其中 135 人(44.7%)的父母为近亲。其中 286 例(94.7%)通过新生儿筛查确诊,14 例(4.6%)通过家族筛查确诊,2 例(0.06%)通过临床症状确诊。有 92 名(30.5%)患者在随访中被诊断为严重缺乏症,210 名(69.5%)患者被诊断为部分缺乏症。共检测到 306 个变异体。其中检测到 20 个不同的变体(3 个新变体 - 3 个罕见变体)和 31 个不同的基因型。最常检测到的 3 个变异是 c.410G>A(p.Arg137His;47.3%)、c.1270G>C(p.Asp424His;29.7%)和 c.38_44delGCGGCTGinsTCC(p.Cys13Phefs*36;15.3%)。最常见的三种基因型是 c.410G>A (p.Arg137His) / c.1270G>C (p.Asp424His) 复合杂合型(32.4%)、c.410G>A(p.Arg137His)同基因杂合子(24.8%),以及 c.38_44delGCGGCTGinsTCC (p.Cys13Phefs*36) / c.1270G>C (p.Asp424His) 复合杂合子(12.2%)。据统计,c.410G>A(p.Arg137His)同源变异、c.38_44delGCGGCTGinsTCC(p.Cys13Phefs*36)同源变异和c.38_44delGCGGCTGinsTCC(p.Cys13Phefs*36)/c.410G>A(p.Arg137His)复合杂合变异患者与深度缺乏症有显著相关性。c.410G>A(p.Arg137His)/c.1270G>C(p.Asp424His)变异的复合杂合子与部分缺乏症明显相关:结论:BTD 基因型与生化表型之间的关联并不总是一致的。我们的研究提供了有价值的数据,在文献中增加了基因型与表型相关的变异,并增加了三个新的变异,这些变异可为临床随访提供重要指导。
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引用次数: 0
Common complications in spinal muscular atrophy (SMA) type 1 after nusinersen treatment. 努西那生治疗后 1 型脊髓性肌萎缩症(SMA)的常见并发症。
Pub Date : 2024-11-16 DOI: 10.24953/turkjpediatr.2024.4527
Yiğithan Güzin, Osman Büyükşen, Pınar Gençpınar, Nihal Olgaç Dündar, Figen Baydan

Background: Spinal muscular atrophy (SMA) is an inherited disease with progressive muscle weakness and atrophy. Despite the new treatments developed recently, primary and secondary effects of muscle weakness in patients with SMA cause mortality and morbidity. The aim of this study is to identify common problems in the follow-up of patients after new treatment modalities and to examine the difficulties in management of these problems.

Methods: The study included 16 patients diagnosed with SMA type 1 according to clinical findings and genetic results between 2017 and 2022. The patients were divided into two groups as living and deceased, and complications were examined and compared between the groups.

Results: The patients comprised 8 (50%) females and 8 (50%) males with a median age at diagnosis of 3 months. The patients had a history of gastrointestinal problems, orthopedic problems, infection and sepsis, and especially respiratory distress. Death occurred in 8 (50%) patients during follow-up (median age 38 months). Mortality was higher in patients who needed tracheostomy and had gastroesophageal reflux. The survival rate was better in patients who received more nusinersen treatment and had a higher CHOP-INTEND score.

Conclusions: Despite new-generation treatments for SMA type 1, morbidity and mortality rates remain very high. As the survival rate in SMA type 1 increases, the incidence of complications similar to those frequently seen in SMA type 2 and type 3 patients also increases. The follow-up and treatment of patients with SMA should be undertaken by a multidisciplinary team.

背景:脊髓性肌萎缩症(SMA脊髓性肌萎缩症(SMA)是一种遗传性疾病,患者会逐渐出现肌肉无力和萎缩。尽管最近开发出了新的治疗方法,但 SMA 患者肌无力的原发性和继发性影响仍会导致死亡和发病。本研究旨在找出新治疗方法后患者随访过程中的常见问题,并探讨处理这些问题的困难:研究纳入了2017年至2022年间根据临床结果和基因结果确诊为SMA 1型的16名患者。将患者分为存活和死亡两组,并对两组患者的并发症进行研究和比较:患者中有8名女性(50%)和8名男性(50%),确诊时的中位年龄为3个月。患者有胃肠道疾病、骨科疾病、感染和败血症病史,尤其是呼吸困难。随访期间,有 8 名患者(50%)死亡(中位年龄为 38 个月)。需要气管造口术和胃食管反流的患者死亡率较高。接受更多的奴西奈森治疗和CHOP-INTEND评分较高的患者存活率更高:结论:尽管对 SMA 1 型采用了新一代治疗方法,但发病率和死亡率仍然很高。结论:尽管对 SMA 1 型采用了新一代治疗方法,但发病率和死亡率仍然很高。随着 SMA 1 型存活率的提高,类似于 SMA 2 型和 3 型患者常见并发症的发生率也在增加。对 SMA 患者的随访和治疗应由多学科团队负责。
{"title":"Common complications in spinal muscular atrophy (SMA) type 1 after nusinersen treatment.","authors":"Yiğithan Güzin, Osman Büyükşen, Pınar Gençpınar, Nihal Olgaç Dündar, Figen Baydan","doi":"10.24953/turkjpediatr.2024.4527","DOIUrl":"https://doi.org/10.24953/turkjpediatr.2024.4527","url":null,"abstract":"<p><strong>Background: </strong>Spinal muscular atrophy (SMA) is an inherited disease with progressive muscle weakness and atrophy. Despite the new treatments developed recently, primary and secondary effects of muscle weakness in patients with SMA cause mortality and morbidity. The aim of this study is to identify common problems in the follow-up of patients after new treatment modalities and to examine the difficulties in management of these problems.</p><p><strong>Methods: </strong>The study included 16 patients diagnosed with SMA type 1 according to clinical findings and genetic results between 2017 and 2022. The patients were divided into two groups as living and deceased, and complications were examined and compared between the groups.</p><p><strong>Results: </strong>The patients comprised 8 (50%) females and 8 (50%) males with a median age at diagnosis of 3 months. The patients had a history of gastrointestinal problems, orthopedic problems, infection and sepsis, and especially respiratory distress. Death occurred in 8 (50%) patients during follow-up (median age 38 months). Mortality was higher in patients who needed tracheostomy and had gastroesophageal reflux. The survival rate was better in patients who received more nusinersen treatment and had a higher CHOP-INTEND score.</p><p><strong>Conclusions: </strong>Despite new-generation treatments for SMA type 1, morbidity and mortality rates remain very high. As the survival rate in SMA type 1 increases, the incidence of complications similar to those frequently seen in SMA type 2 and type 3 patients also increases. The follow-up and treatment of patients with SMA should be undertaken by a multidisciplinary team.</p>","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"66 5","pages":"567-577"},"PeriodicalIF":0.0,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142712366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adaptation of the ''Food Allergy Self-Efficacy Scale for Parents''(FASE-P) to Turkish: a validity and reliability study. 根据土耳其语改编的 "食物过敏家长自我效能量表"(FASE-P):有效性和可靠性研究。
Pub Date : 2024-11-16 DOI: 10.24953/turkjpediatr.2024.4691
Nilay Çalışkan, Şeyma Genç, Güler Yıldırım, Hamit Bologur, Hilal Güngör, Merve Karaca Şahin, Muhammed Fatih Erbay, Şefika İlknur Kökcü Karadağ, Özlem Terzi, Deniz Özçeker

Background: Food allergy is a public health issue that has a significant impact on the lives of families. Parental self-efficacy/confidence is important in managing food allergies. The aim of this study is to validate the "Food Allergy Self-Efficacy Scale for Parents" (FASE-P) and assess parental self-efficacy in managing their child's food allergy.

Methods: Turkish version of the FASE-P (T-FASE-P) was administered to 347 parents of children aged 0-18 who had been followed for at least one month due to food allergy at the Pediatric Allergy Clinic of Prof. Dr. Cemil Taşcıoğlu City Hospital between September 1 and December 31, 2023, through face-to-face interviews and online surveys for parents of children with food allergies from the general population. Content validity, exploratory factor analysis (EFA), and confirmatory factor analysis (CFA) were conducted to evaluate the validity of the scale. General Self-Efficacy Scale (GSES) was used for concurrent criterion validity. Internal consistency analysis, test-retest application, and item analysis were conducted to assess its reliability.

Results: T-FASE-P scale initially contained 21 items, and the Cronbach's alpha coefficient (α) calculated in this form was found to be 0.89. Later, when 4 items were excluded, the 17-item version of the scale was calculated as α=0.90. The intra-class correlation coefficient between the test and re-test was found to be 0.972. The content validity index value of the scale was calculated as 0.99, indicating that the content validity was at a sufficient level. In the EFA, it was determined that the scale formed a three-factor structural model and that this model explained 60.82% of the total variance. As a result of the CFA, the fit indices were calculated as χ2/df=2.341, GFI=0.919, TLI=0.950, indicating a good level of fit. Based on the analysis results, T-FASE-P consists of 17 items and three subscales.

Conclusion: T-FASE-P scale is a valid and reliable measurement tool that can be used to determine the food allergy self-efficacy of Turkish parents.

背景:食物过敏是一个对家庭生活有重大影响的公共卫生问题。家长的自我效能感/自信心对管理食物过敏非常重要。本研究旨在验证 "父母食物过敏自我效能量表"(FASE-P),并评估父母在管理子女食物过敏方面的自我效能:方法:2023 年 9 月 1 日至 12 月 31 日期间,通过面对面访谈和在线调查的方式,对 Cemil Taşcıoğlu 市医院儿科过敏门诊因食物过敏而接受至少一个月随访的 347 名 0-18 岁儿童的父母进行了土耳其语版 FASE-P (T-FASE-P)问卷调查。为评估量表的有效性,对其进行了内容效度、探索性因子分析(EFA)和确证性因子分析(CFA)。一般自我效能感量表(GSES)用于并行标准效度。对其信度进行了内部一致性分析、重测应用和项目分析:T-FASE-P量表最初包含21个项目,计算得出的Cronbach's α系数(α)为0.89。后来,在剔除 4 个项目后,17 个项目版本的量表计算结果为 α=0.90。测试与复测之间的类内相关系数为 0.972。经计算,量表的内容效度指数值为 0.99,表明其内容效度处于充分水平。在 EFA 中,确定量表形成了一个三因素结构模型,该模型解释了总方差的 60.82%。经过 CFA 计算,拟合指数为 χ2/df=2.341,GFI=0.919,TLI=0.950,表明拟合水平良好。根据分析结果,T-FASE-P 由 17 个项目和 3 个分量表组成:T-FASE-P量表是一种有效、可靠的测量工具,可用于确定土耳其家长的食物过敏自我效能。
{"title":"Adaptation of the ''Food Allergy Self-Efficacy Scale for Parents''(FASE-P) to Turkish: a validity and reliability study.","authors":"Nilay Çalışkan, Şeyma Genç, Güler Yıldırım, Hamit Bologur, Hilal Güngör, Merve Karaca Şahin, Muhammed Fatih Erbay, Şefika İlknur Kökcü Karadağ, Özlem Terzi, Deniz Özçeker","doi":"10.24953/turkjpediatr.2024.4691","DOIUrl":"https://doi.org/10.24953/turkjpediatr.2024.4691","url":null,"abstract":"<p><strong>Background: </strong>Food allergy is a public health issue that has a significant impact on the lives of families. Parental self-efficacy/confidence is important in managing food allergies. The aim of this study is to validate the \"Food Allergy Self-Efficacy Scale for Parents\" (FASE-P) and assess parental self-efficacy in managing their child's food allergy.</p><p><strong>Methods: </strong>Turkish version of the FASE-P (T-FASE-P) was administered to 347 parents of children aged 0-18 who had been followed for at least one month due to food allergy at the Pediatric Allergy Clinic of Prof. Dr. Cemil Taşcıoğlu City Hospital between September 1 and December 31, 2023, through face-to-face interviews and online surveys for parents of children with food allergies from the general population. Content validity, exploratory factor analysis (EFA), and confirmatory factor analysis (CFA) were conducted to evaluate the validity of the scale. General Self-Efficacy Scale (GSES) was used for concurrent criterion validity. Internal consistency analysis, test-retest application, and item analysis were conducted to assess its reliability.</p><p><strong>Results: </strong>T-FASE-P scale initially contained 21 items, and the Cronbach's alpha coefficient (α) calculated in this form was found to be 0.89. Later, when 4 items were excluded, the 17-item version of the scale was calculated as α=0.90. The intra-class correlation coefficient between the test and re-test was found to be 0.972. The content validity index value of the scale was calculated as 0.99, indicating that the content validity was at a sufficient level. In the EFA, it was determined that the scale formed a three-factor structural model and that this model explained 60.82% of the total variance. As a result of the CFA, the fit indices were calculated as χ2/df=2.341, GFI=0.919, TLI=0.950, indicating a good level of fit. Based on the analysis results, T-FASE-P consists of 17 items and three subscales.</p><p><strong>Conclusion: </strong>T-FASE-P scale is a valid and reliable measurement tool that can be used to determine the food allergy self-efficacy of Turkish parents.</p>","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"66 5","pages":"534-543"},"PeriodicalIF":0.0,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142712360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sleep in hospitalized children with cancer: relationship with psychiatric disorders and hospital conditions. 住院癌症患儿的睡眠:与精神障碍和住院条件的关系。
Pub Date : 2024-11-16 DOI: 10.24953/turkjpediatr.2024.4769
Burcu Güneydaş Yıldırım, Hasan Cem Aykutlu, Tuba Eren

Background: Children with cancer often undergo prolonged and recurrent hospitalization, which leads to an increased incidence of sleep disruptions and psychiatric disorders. This study aimed to objectively quantify the prevalence of sleep disruptions in hospitalized pediatric oncology patients and to determine the effects of psychiatric disorders, treatment regimens, and hospital conditions on sleep patterns.

Method: This cross-sectional study included 39 children who were undergoing treatment and monitoring in the pediatric oncology inpatient service. Parents completed questionnaires providing information about their child's sleep patterns, quality of life, and hospital conditions. The children were monitored for five days using actigraphy to record sleep parameters. They were evaluated with a semi-structured interview form (Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version-DSM 5-Turkish Adaptation) for psychiatric diagnoses.

Results: Sleep disruptions were identified in 27 (69.2%) children with cancer. In addition to adjustment disorder and anxiety disorder psychiatric diagnoses, behavioral problems and emotional symptoms were more common in the group with sleep disruptions. Actigraphy measurements indicated that poor sleep was associated with younger age, recent cancer diagnosis, specific phobias, depression, daytime napping, and frequent vital sign assessments.

Conclusion: Sleep problems in hospitalized children with cancer are linked to psychiatric comorbidities, treatment routines, and hospital conditions. By recognizing psychiatric symptoms and optimizing hospital conditions that affect sleep, healthcare providers can enhance the quality of sleep for these children.

背景:癌症患儿往往需要长期和反复住院,这导致睡眠紊乱和精神障碍的发生率增加。本研究旨在客观量化住院儿科肿瘤患者睡眠紊乱的发生率,并确定精神障碍、治疗方案和住院条件对睡眠模式的影响:这项横断面研究包括 39 名正在接受儿科肿瘤住院治疗和监测的儿童。家长填写了调查问卷,提供了有关孩子睡眠模式、生活质量和医院条件的信息。儿童接受了为期五天的监测,使用行为记录仪记录睡眠参数。他们还接受了半结构化访谈表(学龄儿童情感障碍和精神分裂症诊断表--现在和终生版--DSM 5-土耳其语改编版)的精神病诊断评估:27名(69.2%)癌症患儿出现睡眠障碍。除了适应障碍和焦虑障碍的精神诊断外,行为问题和情绪症状在睡眠障碍儿童中也更为常见。动图测量结果表明,睡眠质量差与年龄较小、近期癌症诊断、特定恐惧症、抑郁、白天打盹和频繁的生命体征评估有关:结论:住院癌症患儿的睡眠问题与精神疾病、治疗程序和医院条件有关。通过识别精神症状和优化影响睡眠的医院条件,医护人员可以提高这些儿童的睡眠质量。
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引用次数: 0
Parvovirus B19 infection in children: Is it more severe than expected? 儿童感染 Parvovirus B19:是否比预期的更严重?
Pub Date : 2024-11-16 DOI: 10.24953/turkjpediatr.2024.4895
Öznur Ege Akdi, Kübra Aykaç, Ali Bülent Cengiz, Yasemin Özsürekçi
{"title":"Parvovirus B19 infection in children: Is it more severe than expected?","authors":"Öznur Ege Akdi, Kübra Aykaç, Ali Bülent Cengiz, Yasemin Özsürekçi","doi":"10.24953/turkjpediatr.2024.4895","DOIUrl":"https://doi.org/10.24953/turkjpediatr.2024.4895","url":null,"abstract":"","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"66 5","pages":"625-629"},"PeriodicalIF":0.0,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142712368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of lead levels in children with chronic constipation. 评估慢性便秘儿童体内的铅含量。
Pub Date : 2024-11-16 DOI: 10.24953/turkjpediatr.2024.4900
Abdurrahman Zarif Güney, Güzide Doğan, Ali Toprak

Objectives: This study aimed to assess blood and hair lead levels (BLL and HLL) in children with chronic constipation and compare them to healthy children; and investigated lead exposure's role in the etiology of constipation. It also explored the correlation between BLL and HLL.

Study design: The study included 84 constipated children aged 3-18 years as the case group and an equal number of constipation-free children as controls. Organic diseases were ruled out through history-taking, physical exams and laboratory tests. Blood and hair samples were collected and analyzed for lead levels using standardized methods.

Results: The constipated children group had significantly higher BLL (3.66 µg/dL) compared to the control group (1.61 µg/dL) with no significant HLL difference. Additionally, 48.8% of constipated children exceeded the reference value of 3.5 μg/dL, in contrast to 4.8% of the control group. BLL was unaffected by gender and age, while HLL were higher in girls and low ages. No significant correlation existed between BLL and HLL. The age of the housing showed a positive correlation with higher BLL and HLL. Lead exposure sources like drinking water, home renovation history, parental smoking, or nearby industrial facilities showed no significant relationships with lead levels.

Conclusions: Understanding the constipation-lead exposure link is crucial for prevention and intervention. HLL may vary with gender and age due to external lead particles, which is why BLL continues to be a more reliable measure. Healthcare providers should remember to investigate lead exposure risk factors in constipation patients and test BLL when necessary.

研究目的本研究旨在评估慢性便秘儿童血液和毛发中的铅含量(BLL 和 HLL),并将其与健康儿童进行比较;同时调查铅暴露在便秘病因中的作用。研究还探讨了BLL和HLL之间的相关性:研究包括 84 名 3-18 岁的便秘儿童作为病例组,以及同等数量的无便秘儿童作为对照组。通过病史采集、体格检查和实验室检测排除了器质性疾病。采集了血液和毛发样本,并采用标准方法分析了铅含量:结果:与对照组(1.61 µg/dL)相比,便秘儿童组的铅含量(BLL)(3.66 µg/dL)明显较高,而 HLL 无明显差异。此外,48.8% 的便秘儿童的血蓝蛋白超过了 3.5 微克/分升的参考值,而对照组只有 4.8%。BLL不受性别和年龄的影响,而HLL在女孩和低龄儿童中较高。BLL和HLL之间没有明显的相关性。住房的年龄与较高的 BLL 和 HLL 呈正相关。饮用水、房屋装修史、父母吸烟或附近的工业设施等铅暴露源与铅含量无明显关系:结论:了解便秘与铅暴露之间的联系对于预防和干预至关重要。由于外部铅微粒的影响,HLL 可能会随着性别和年龄的变化而变化,这就是为什么 BLL 仍然是一种更可靠的测量方法。医疗服务提供者应牢记调查便秘患者的铅暴露风险因素,并在必要时检测BLL。
{"title":"Evaluation of lead levels in children with chronic constipation.","authors":"Abdurrahman Zarif Güney, Güzide Doğan, Ali Toprak","doi":"10.24953/turkjpediatr.2024.4900","DOIUrl":"https://doi.org/10.24953/turkjpediatr.2024.4900","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to assess blood and hair lead levels (BLL and HLL) in children with chronic constipation and compare them to healthy children; and investigated lead exposure's role in the etiology of constipation. It also explored the correlation between BLL and HLL.</p><p><strong>Study design: </strong>The study included 84 constipated children aged 3-18 years as the case group and an equal number of constipation-free children as controls. Organic diseases were ruled out through history-taking, physical exams and laboratory tests. Blood and hair samples were collected and analyzed for lead levels using standardized methods.</p><p><strong>Results: </strong>The constipated children group had significantly higher BLL (3.66 µg/dL) compared to the control group (1.61 µg/dL) with no significant HLL difference. Additionally, 48.8% of constipated children exceeded the reference value of 3.5 μg/dL, in contrast to 4.8% of the control group. BLL was unaffected by gender and age, while HLL were higher in girls and low ages. No significant correlation existed between BLL and HLL. The age of the housing showed a positive correlation with higher BLL and HLL. Lead exposure sources like drinking water, home renovation history, parental smoking, or nearby industrial facilities showed no significant relationships with lead levels.</p><p><strong>Conclusions: </strong>Understanding the constipation-lead exposure link is crucial for prevention and intervention. HLL may vary with gender and age due to external lead particles, which is why BLL continues to be a more reliable measure. Healthcare providers should remember to investigate lead exposure risk factors in constipation patients and test BLL when necessary.</p>","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"66 5","pages":"525-533"},"PeriodicalIF":0.0,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142712355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the predictive factors in the gastrointestinal involvement of patients with immunoglobulin A vasculitis. 探索免疫球蛋白 A 血管炎患者胃肠道受累的预测因素。
Pub Date : 2024-11-16 DOI: 10.24953/turkjpediatr.2024.4797
Betül Öksel, Nihal Şahin, Hafize Emine Sönmez

Background: Immunoglobulin A vasculitis (IgAV), the most common systemic vasculitis in children, typically presents with gastrointestinal (GI) symptoms in about half of cases. This study aimed to analyze the clinical and laboratory findings of patients with IgAV regarding GI involvement.

Methods: We compared the GI involvement data of the patients diagnosed with IgAV.

Results: Of the 210 patients (60.5% female and 39.5% male), 101 had GI involvement, with abdominal pain being the predominant symptom (n=98). White blood cell, neutrophil, monocyte, and platelet counts, C-reactive protein, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI) were significantly elevated in patients with GI involvement (p<0.001, p<0.001, p=0.01, p=0.005, p=0.002, p<0.001, p=0.03, p=0.001, p<0.001, p<0.001, respectively). The cutoff values for SII (>1035.7), SIRI (>1.65), NLR (>2.73), and MLR (>0.28) were determined, yielding respective sensitivities of 46%, 59%, 47%, and 53%, specificities of 83.1%, 69.1%, 81.3%, and 71.9%. Corresponding areas under the curve were 0.658, 0.668, 0.649, and 0.634, respectively (all p<0.001).

Conclusion: Although IgAV is a self-limiting disease, GI involvement can lead to serious consequences. Systemic inflammatory indices such as SII and SIRI may be indicative in identifying patients with GI involvement.

背景:免疫球蛋白A型血管炎(IgAV)是儿童中最常见的全身性血管炎,约半数病例通常伴有胃肠道(GI)症状。本研究旨在分析 IgAV 患者胃肠道受累的临床和实验室结果:我们比较了确诊为 IgAV 患者的消化道受累数据:结果:在210名患者(60.5%为女性,39.5%为男性)中,101名患者的消化道受累,腹痛是主要症状(98人)。消化道受累患者的白细胞、中性粒细胞、单核细胞和血小板计数、C 反应蛋白、中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)、单核细胞与淋巴细胞比值(MLR)、全身免疫炎症指数(SII)和全身炎症反应指数(SIRI)显著升高(p1035.通过测定 SIRI(>1.65)、NLR(>2.73)和 MLR(>0.28),结果显示敏感性分别为 46%、59%、47% 和 53%,特异性分别为 83.1%、69.1%、81.3% 和 71.9%。相应的曲线下面积分别为 0.658、0.668、0.649 和 0.634(均为 p):尽管 IgAV 是一种自限性疾病,但消化道受累可导致严重后果。SII和SIRI等全身炎症指数可能对鉴别消化道受累患者有指示作用。
{"title":"Exploring the predictive factors in the gastrointestinal involvement of patients with immunoglobulin A vasculitis.","authors":"Betül Öksel, Nihal Şahin, Hafize Emine Sönmez","doi":"10.24953/turkjpediatr.2024.4797","DOIUrl":"https://doi.org/10.24953/turkjpediatr.2024.4797","url":null,"abstract":"<p><strong>Background: </strong>Immunoglobulin A vasculitis (IgAV), the most common systemic vasculitis in children, typically presents with gastrointestinal (GI) symptoms in about half of cases. This study aimed to analyze the clinical and laboratory findings of patients with IgAV regarding GI involvement.</p><p><strong>Methods: </strong>We compared the GI involvement data of the patients diagnosed with IgAV.</p><p><strong>Results: </strong>Of the 210 patients (60.5% female and 39.5% male), 101 had GI involvement, with abdominal pain being the predominant symptom (n=98). White blood cell, neutrophil, monocyte, and platelet counts, C-reactive protein, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI) were significantly elevated in patients with GI involvement (p<0.001, p<0.001, p=0.01, p=0.005, p=0.002, p<0.001, p=0.03, p=0.001, p<0.001, p<0.001, respectively). The cutoff values for SII (>1035.7), SIRI (>1.65), NLR (>2.73), and MLR (>0.28) were determined, yielding respective sensitivities of 46%, 59%, 47%, and 53%, specificities of 83.1%, 69.1%, 81.3%, and 71.9%. Corresponding areas under the curve were 0.658, 0.668, 0.649, and 0.634, respectively (all p<0.001).</p><p><strong>Conclusion: </strong>Although IgAV is a self-limiting disease, GI involvement can lead to serious consequences. Systemic inflammatory indices such as SII and SIRI may be indicative in identifying patients with GI involvement.</p>","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"66 5","pages":"599-607"},"PeriodicalIF":0.0,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142712356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interpretation of pseudothrombocytopenia using platelet histograms and flags in a hematology autoanalyzer in a healthy child: a case report. 利用健康儿童血液自动分析仪中的血小板直方图和标志解读假性血小板减少症:病例报告。
Pub Date : 2024-11-16 DOI: 10.24953/turkjpediatr.2024.5090
Emine Dönmez, Zühre Kaya

Background: Pseudothrombocytopenia is a spurious thrombocytopenia caused mostly by ethylenediaminetetraacetic acid (EDTA) use, and if detected early, unnecessary testing and treatment can be avoided. We present pseudothrombocytopenia caused by EDTA and citrate in an asymptomatic healthy child, as well as the value of using peripheral blood smear, platelet histogram, and flag data.

Case: A previously healthy 13-year-old girl with thrombocytopenia who developed tonsillitis 12 days previously was referred to our hematology department. Laboratory tests revealed severe thrombocytopenia (17x103/µL) in EDTA samples. A peripheral blood smear revealed numerous platelet clumping. We hypothesized EDTA-dependent pseudothrombocytopenia and ordered a platelet count by citrate tube. A citrate tube revealed thrombocytopenia with a platelet count of 55x103/µL. The platelet count (175x103/µL) returned to normal with heparin tubing. All blood samples had a similar platelet histogram and flags in the autoanalyzer. The platelet histogram indicated a serrated/sawtooth curve containing the largest platelet aggregates. Platelet flags alert messages about platelet clumping.

Conclusions: Peripheral blood smear is the most reliable test for pseudothrombocytopenia. If the physician has no experience with smear examination, both laboratory technician and physician should be aware of abnormal platelet histograms and platelet clumping messages in platelet flags, which indicate pseudothrombocytopenia.

背景:假性血小板减少症是一种假性血小板减少症,主要由使用乙二胺四乙酸(EDTA)引起,如果及早发现,可以避免不必要的检查和治疗。我们介绍了一名无症状健康儿童因使用 EDTA 和枸橼酸引起的假性血小板减少症,以及使用外周血涂片、血小板直方图和标志物数据的价值:一名患有血小板减少症的 13 岁健康女孩于 12 天前患扁桃体炎,被转诊至我院血液科。实验室检查发现,EDTA 样本中血小板严重减少(17x103/μL)。外周血涂片显示大量血小板凝集。我们推测是 EDTA 依赖性假性血小板减少症,并要求用枸橼酸管进行血小板计数。枸橼酸管显示血小板减少,血小板计数为 55x103/μL。使用肝素管后,血小板计数(175x103/µL)恢复正常。所有血样的血小板直方图和自动分析仪上的标志都很相似。血小板直方图显示出一条锯齿状曲线,其中包含最大的血小板聚集体。血小板标记提示血小板聚集的信息:结论:外周血涂片是检测假性血小板减少症最可靠的方法。如果医生没有涂片检查的经验,实验室技术人员和医生都应注意血小板直方图异常和血小板标志中的血小板凝集信息,这表明存在假性血小板减少症。
{"title":"Interpretation of pseudothrombocytopenia using platelet histograms and flags in a hematology autoanalyzer in a healthy child: a case report.","authors":"Emine Dönmez, Zühre Kaya","doi":"10.24953/turkjpediatr.2024.5090","DOIUrl":"https://doi.org/10.24953/turkjpediatr.2024.5090","url":null,"abstract":"<p><strong>Background: </strong>Pseudothrombocytopenia is a spurious thrombocytopenia caused mostly by ethylenediaminetetraacetic acid (EDTA) use, and if detected early, unnecessary testing and treatment can be avoided. We present pseudothrombocytopenia caused by EDTA and citrate in an asymptomatic healthy child, as well as the value of using peripheral blood smear, platelet histogram, and flag data.</p><p><strong>Case: </strong>A previously healthy 13-year-old girl with thrombocytopenia who developed tonsillitis 12 days previously was referred to our hematology department. Laboratory tests revealed severe thrombocytopenia (17x103/µL) in EDTA samples. A peripheral blood smear revealed numerous platelet clumping. We hypothesized EDTA-dependent pseudothrombocytopenia and ordered a platelet count by citrate tube. A citrate tube revealed thrombocytopenia with a platelet count of 55x103/µL. The platelet count (175x103/µL) returned to normal with heparin tubing. All blood samples had a similar platelet histogram and flags in the autoanalyzer. The platelet histogram indicated a serrated/sawtooth curve containing the largest platelet aggregates. Platelet flags alert messages about platelet clumping.</p><p><strong>Conclusions: </strong>Peripheral blood smear is the most reliable test for pseudothrombocytopenia. If the physician has no experience with smear examination, both laboratory technician and physician should be aware of abnormal platelet histograms and platelet clumping messages in platelet flags, which indicate pseudothrombocytopenia.</p>","PeriodicalId":101314,"journal":{"name":"The Turkish journal of pediatrics","volume":"66 5","pages":"666-671"},"PeriodicalIF":0.0,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142712358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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The Turkish journal of pediatrics
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