Polyamine-containing natural products: structure, bioactivity, and biosynthesis†

IF 10.6 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Natural Product Reports Pub Date : 2024-04-24 DOI:10.1039/d2np00087c

Qingshan Long , Wen Zhou , Haibo Zhou , Ying Tang , Wu Chen , Qingshu Liu , Xiaoying Bian

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Abstract

Covering: 2005 to August, 2023

Polyamine-containing natural products (NPs) have been isolated from a wide range of terrestrial and marine organisms and most of them exhibit remarkable and diverse activities, including antimicrobial, antiprotozoal, antiangiogenic, antitumor, antiviral, iron-chelating, anti-depressive, anti-inflammatory, insecticidal, antiobesity, and antioxidant properties. Their extraordinary activities and potential applications in human health and agriculture attract increasing numbers of studies on polyamine-containing NPs. In this review, we summarized the source, structure, classification, bioactivities and biosynthesis of polyamine-containing NPs, focusing on the biosynthetic mechanism of polyamine itself and representative polyamine alkaloids, polyamine-containing siderophores with catechol/hydroxamate/hydroxycarboxylate groups, nonribosomal peptide-(polyketide)-polyamine (NRP-(PK)-PA), and NRP-PK-long chain poly-fatty amine (lcPFAN) hybrid molecules.

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含多胺的天然产物：结构、生物活性和生物合成。

涵盖范围：2005年至2023年8月，已从各种陆地和海洋生物中分离出含有多胺的天然产物，其中大多数具有显著和多样的活性，包括抗菌、抗原生动物、抗血管生成、抗肿瘤、抗病毒、铁螯合、抗抑郁、抗炎、杀虫、抗肥胖和抗氧化特性。它们在人类健康和农业中的非凡活性和潜在应用吸引了越来越多关于含多胺NP的研究。在这篇综述中，我们综述了含多胺NP的来源、结构、分类、生物活性和生物合成，重点介绍了多胺本身和代表性多胺生物碱的生物合成机制、具有邻苯二酚/羟肟酸盐/羟基羧酸盐基团的含多胺铁载体、非核糖体肽-（聚酮）-多胺（NRP-（PK）-PA），和NRP-PK长链多脂肪胺（lcPFAN）杂化分子。

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来源期刊

Natural Product Reports 化学-生化与分子生物学

CiteScore

21.20

自引率

3.40%

发文量

127

审稿时长

1.7 months

期刊介绍： Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis. With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results. NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.