Retinal nerve fiber layer and ganglion cell complex thickness in diabetic smokers without diabetic retinopathy.

IF 1.6 4区 医学 Q3 OPHTHALMOLOGY Cutaneous and Ocular Toxicology Pub Date : 2024-03-01 Epub Date: 2023-10-24 DOI:10.1080/15569527.2023.2268162
Kübra Özata Gündoğdu, Emine Doğan, Erkan Çelik, Gürsoy Alagöz
{"title":"Retinal nerve fiber layer and ganglion cell complex thickness in diabetic smokers without diabetic retinopathy.","authors":"Kübra Özata Gündoğdu, Emine Doğan, Erkan Çelik, Gürsoy Alagöz","doi":"10.1080/15569527.2023.2268162","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To compare the thickness of the retinal nerve fiber layer (RNFL) and macular ganglion cell-inner plexiform layer (GC-IPL) in smoker and nonsmoker diabetics without diabetic retinopathy.</p><p><strong>Materials and methods: </strong>Patients with diabetes were divided into two groups according to their smoking status: Group 1 consisted of 38 smoker diabetics who had chronically smoked more than 20 cigarettes per day for more than five years; Group 2 consisted of 38 nonsmoker diabetics. After a detailed ophthalmologic examination, the mean and regional (superior, supratemporal, inferior, inferotemporal, temporal, nasal, superonasal, and inferonasal) RNFL and GC-IPL thicknesses were measured with spectral-domain optic coherence tomography (SD-OCT) and compared between groups.</p><p><strong>Results: </strong>The mean age was 54.7 ± 10.5 and 51.2 ± 9.7 years in the smoker and nonsmoker groups, respectively (<i>p</i> = 0.14). Gender, duration of diabetes, and the mean axial length were similar between groups (<i>p:</i>0.43, <i>p</i>:0.54, <i>p</i>: 0.52, respectively). Mean RNFL thickness was 89.1 ± 8.0 µm in the smoker group and 93.4 ± 7.0 µm in the nonsmoker group, and it was significantly thinner in the smoker group (<i>p</i> = 0.01). The temporal RNFL thickness in the smoker group was thinner than in the nonsmoker group (<i>p</i> = 0.02). There was no difference in superior, inferior, and nasal RNFL thicknesses between the groups (<i>p</i> = 0.31, <i>p</i> = 0.12, <i>p</i> = 0.39, respectively). The mean macular GC-IPL thickness of the smoker and nonsmoker groups was 78.53 ± 15.74 µm and 83.08 ± 5.85 µm, respectively (<i>p</i> = 0.09). Superior, superonasal, inferonasal, inferior, inferotemporal, and superotemporal quadrant GC-IPL thicknesses were similar between the groups (<i>p</i> = 0.07, <i>p</i> = 0.60, <i>p</i> = 0.55, <i>p</i> = 0.77, <i>p</i> = 0.71, <i>p =</i> 0.08, respectively). The groups showed no difference in minimum GC-IPL thickness (p = 0.43). There was a significant negative correlation between smoking exposure and mean, inferior quadrant RNFL thicknesses in the smoker group (<i>p</i> = 0.04, r= -0.32, and <i>p</i> = 0.01, r= -0.39, respectively).</p><p><strong>Conclusion: </strong>Mean RNFL thickness was significantly thinner in smoker diabetics. Although not statistically significant, especially mean, superior, and superotemporal GC-IPL was thinner in smoker diabetics. The results suggest a potential association between the coexistence of diabetes and smoking with alterations in RNFL and GC-IPL thickness.</p>","PeriodicalId":11023,"journal":{"name":"Cutaneous and Ocular Toxicology","volume":" ","pages":"22-26"},"PeriodicalIF":1.6000,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cutaneous and Ocular Toxicology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/15569527.2023.2268162","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/10/24 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Purpose: To compare the thickness of the retinal nerve fiber layer (RNFL) and macular ganglion cell-inner plexiform layer (GC-IPL) in smoker and nonsmoker diabetics without diabetic retinopathy.

Materials and methods: Patients with diabetes were divided into two groups according to their smoking status: Group 1 consisted of 38 smoker diabetics who had chronically smoked more than 20 cigarettes per day for more than five years; Group 2 consisted of 38 nonsmoker diabetics. After a detailed ophthalmologic examination, the mean and regional (superior, supratemporal, inferior, inferotemporal, temporal, nasal, superonasal, and inferonasal) RNFL and GC-IPL thicknesses were measured with spectral-domain optic coherence tomography (SD-OCT) and compared between groups.

Results: The mean age was 54.7 ± 10.5 and 51.2 ± 9.7 years in the smoker and nonsmoker groups, respectively (p = 0.14). Gender, duration of diabetes, and the mean axial length were similar between groups (p:0.43, p:0.54, p: 0.52, respectively). Mean RNFL thickness was 89.1 ± 8.0 µm in the smoker group and 93.4 ± 7.0 µm in the nonsmoker group, and it was significantly thinner in the smoker group (p = 0.01). The temporal RNFL thickness in the smoker group was thinner than in the nonsmoker group (p = 0.02). There was no difference in superior, inferior, and nasal RNFL thicknesses between the groups (p = 0.31, p = 0.12, p = 0.39, respectively). The mean macular GC-IPL thickness of the smoker and nonsmoker groups was 78.53 ± 15.74 µm and 83.08 ± 5.85 µm, respectively (p = 0.09). Superior, superonasal, inferonasal, inferior, inferotemporal, and superotemporal quadrant GC-IPL thicknesses were similar between the groups (p = 0.07, p = 0.60, p = 0.55, p = 0.77, p = 0.71, p = 0.08, respectively). The groups showed no difference in minimum GC-IPL thickness (p = 0.43). There was a significant negative correlation between smoking exposure and mean, inferior quadrant RNFL thicknesses in the smoker group (p = 0.04, r= -0.32, and p = 0.01, r= -0.39, respectively).

Conclusion: Mean RNFL thickness was significantly thinner in smoker diabetics. Although not statistically significant, especially mean, superior, and superotemporal GC-IPL was thinner in smoker diabetics. The results suggest a potential association between the coexistence of diabetes and smoking with alterations in RNFL and GC-IPL thickness.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
无糖尿病视网膜病变的糖尿病吸烟者的视网膜神经纤维层和神经节细胞复合体厚度。
目的:比较吸烟者和非吸烟者糖尿病患者视网膜神经纤维层(RNFL)和黄斑神经节细胞内丛状层(GC-IPL)的厚度。材料和方法:糖尿病患者根据吸烟状况分为两组:第一组为38名吸烟糖尿病患者,他们长期每天吸烟20支以上,持续时间超过5年;第2组由38名不吸烟的糖尿病患者组成。在详细的眼科检查后,用光谱域光学相干断层扫描(SD-OCT)测量平均和区域(上、颞上、下、颞下、颞、鼻、鼻上和鼻下)RNFL和GC-IPL厚度,并在各组之间进行比较。结果:平均年龄54.7岁 ± 10.5和51.2 ± 9.7 吸烟组和不吸烟组的年数分别为(p = 0.14)。两组之间的性别、糖尿病持续时间和平均轴长相似(分别为p:0.43、p:0.54、p:0.52)。RNFL平均厚度为89.1 ± 8 µm,吸烟组为93.4 ± 7 µm,吸烟组明显变薄(p = 吸烟组的时间RNFL厚度较不吸烟组薄(p = 0.02)。两组之间的上、下和鼻腔RNFL厚度没有差异(p = 0.31,p = 0.12,p = 0.39)。吸烟者和非吸烟者组的平均黄斑GC-IPL厚度为78.53 ± 15.74 µm和83.08 ± 5.85 µm(p = 0.09)。两组之间上、上、下、下、颞下和颞上象限的GC-IPL厚度相似(p = 0.07,p = 0.60,p = 0.55,p = 0.77,p = 0.71,p = 分别为0.08)。两组的最小GC-IPL厚度没有差异(p = 0.43)。吸烟组的吸烟暴露与平均下象限RNFL厚度之间存在显著的负相关(p = 0.04,r= -0.32和p = 0.01,r= -结论:吸烟糖尿病患者的平均RNFL厚度明显较薄。尽管没有统计学意义,但吸烟糖尿病患者的平均、上、颞上GC-IPL较薄。结果表明,糖尿病和吸烟的共存与RNFL和GC-IPL厚度的变化之间存在潜在的联系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
3.30
自引率
6.20%
发文量
40
审稿时长
1 months
期刊介绍: Cutaneous and Ocular Toxicology is an international, peer-reviewed journal that covers all types of harm to cutaneous and ocular systems. Areas of particular interest include pharmaceutical and medical products; consumer, personal care, and household products; and issues in environmental and occupational exposures. In addition to original research papers, reviews and short communications are invited, as well as concise, relevant, and critical reviews of topics of contemporary significance.
期刊最新文献
Effects on corneal endothelium of intravitreal injection of anti-VEGF drugs. Correction. Isotretinoin increases non-insulin-based surrogate markers of insulin resistance in acne vulgaris patients. The treatment efficacy of 7.5% dapsone gel in papulopustular rosacea: a prospective study. Anti-inflammatory, cytotoxic and morphological impact of phycocyanin on ultraviolet radiation irradiated human fibroblast cells.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1