Changes in Hematological and Hemorheological Parameters Following Mild COVID-19: A 4-Month Follow-Up Study.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-10-10 DOI:10.3390/hematolrep15040057

Janina Bros, Lars Ibershoff, Emily Zollmann, Jonas Zacher, Fabian Tomschi, Hans-Georg Predel, Wilhelm Bloch, Marijke Grau

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Abstract

Background: Coronavirus Disease 2019 (COVID-19) was described to affect red blood cells (RBC) in both severe and mild disease courses. The aim of this study was to investigate whether hematological and hemorheological changes that were previously described for COVID-19 patients after the acute infection state are still prominent after another 4 months to assess potential long-term effects.

Methods: Hematological and RBC rheological parameters, including deformability and aggregation, were measured 41 days after infection in COVID-19 patients and non-COVID control (T0) and 4 months later in COVID-19 patients (T1).

Results: The data confirm alterations in hematological parameters, mainly related to cell volume and hemoglobin concentration, but also reduced deformability and increased aggregation at T0 compared to control. While RBC deformability seems to have recovered, hemoglobin-related parameters and RBC aggregation were still impaired at T1. The changes were thus more pronounced in male COVID-19 patients.

Conclusion: COVID-19-related changes of the RBC partly consist of several months and might be related to persistent symptoms reported by many COVID-19 patients.

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轻度新冠肺炎后血液学和血液流变学参数的变化：4个月随访-Up研究。

背景：2019冠状病毒病（新冠肺炎）被描述为在严重和轻度疾病过程中影响红细胞（RBC）。本研究的目的是调查先前描述的新冠肺炎患者急性感染状态后的血液学和血液流变学变化在另外4个月后是否仍然显著，以评估潜在的长期影响。方法：在新冠肺炎患者和非新冠肺炎对照组（T0）感染后41天和新冠肺炎患者感染后4个月（T1）测量血液学和RBC流变学参数，包括变形能力和聚集性，而且在T0时与对照相比变形性降低和聚集性增加。虽然红细胞的变形能力似乎已经恢复，但血红蛋白相关参数和红细胞聚集在T1时仍然受损。因此，新冠肺炎男性患者的变化更为明显。结论：与新冠肺炎相关的红细胞变化部分由几个月组成，可能与许多新冠肺炎患者报告的持续症状有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.