Investigation of Clinical Histopathologic Features and Metabolic Parameters of ¹⁸F-FDG PET/CT in Invasive Breast Carcinoma with a Micropapillary Component.

IF 0.9 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Molecular Imaging and Radionuclide Therapy Pub Date : 2023-10-20 DOI:10.4274/mirt.galenos.2023.06078

Elife Akgün, Göksel Alçın, Esra Canan Kelten Talu, Tevfik Fikret Çermik, Tuçe Söylemez Akkurt, Ebru Şen, Esra Arslan

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Abstract

Objectives: The aim of this study was to evaluate the correlation between clinical histopathologic features and micropapillary (MP) ratio with the maximum standardized uptake value (SUV_max) derived from ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) in treatment naïve breast cancer.

Methods: Twenty-nine patients diagnosed with breast cancer with a MP component who underwent PET/CT imaging before any local and/or systemic treatment were included in this retrospective study. All clinical histopathological features were recorded. SUV_max values were measured from ¹⁸F-FDG PET images for primary tumors and metastatic axillary lymph nodes.

Results: MP component percentage did not correlate with any clinical histopathological features except age. At early ages, the MP component ratio was significantly higher. Our results showed that there is no significant correlation between the SUV_max value and MP component percentage.

Conclusion: A high SUV_max value is generally expected in aggressive malignancies. However, this assumption may not be valid for the MP subgroup, which has an aggressive course compared to other subgroups in breast cancer.

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18F-FDG PET/CT在具有微乳头成分的浸润性乳腺癌中的临床组织病理学特征和代谢参数研究。

目的：本研究的目的是评估临床组织病理学特征和微毛细血管（MP）比率与来自18F-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（18F-FDG PET/CT）的最大标准化摄取值（SUVmax）在治疗早期癌症中的相关性。方法：本回顾性研究纳入了20例诊断为患有MP成分的癌症乳腺癌的患者，他们在接受任何局部和/或全身治疗前接受了PET/CT成像。记录所有临床组织病理学特征。根据18F-FDG PET图像测量原发性肿瘤和转移性腋窝淋巴结的SUVmax值。结果：除年龄外，MP成分百分比与任何临床组织病理学特征均无相关性。在早期，MP成分比例明显较高。我们的结果表明，SUVmax值和MP成分百分比之间没有显著的相关性。结论：侵袭性恶性肿瘤的SUVmax值通常较高。然而，这一假设可能对MP亚组无效，与癌症的其他亚组相比，MP亚组具有侵袭性过程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Imaging and Radionuclide Therapy RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

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1.30

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0.00%

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期刊介绍： Molecular Imaging and Radionuclide Therapy (Mol Imaging Radionucl Ther, MIRT) is publishes original research articles, invited reviews, editorials, short communications, letters, consensus statements, guidelines and case reports with a literature review on the topic, in the field of molecular imaging, multimodality imaging, nuclear medicine, radionuclide therapy, radiopharmacy, medical physics, dosimetry and radiobiology.