Whole-body bone mineral density and markers of bone homeostasis in adults with normal-weight obesity

Obesity Pillars Pub Date : 2023-09-01 DOI:10.1016/j.obpill.2023.100073

Bryant H. Keirns , Christina M. Sciarrillo , Austin R. Medlin , Samantha M. Hart , Elyse M. Cronic , Sam R. Emerson

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引用次数: 1

Abstract

Background

Normal-weight obesity (NWO) describes individuals with a normal body mass index (BMI), but high body fat percent. NWO are at-risk for cardiometabolic diseases, but little is known about their bone health.

Methods

Adults (N = 24) were classified as NWO (n = 12; 5M/7F) or low body fat percent controls (Con; n = 12; 6M/6F). Body composition and whole-body bone mineral density (BMD) were assessed using DXA. A serum bioplex assay was performed to examine markers related to bone formation and resorption.

Results

In addition to higher body fat percent and visceral fat, NWO had lower whole-body BMD relative to Con (p's < 0.05). Circulating leptin was higher in NWO than Con (p < 0.05). Two biomarkers generally associated with lower bone mass – sclerostin and parathyroid hormone – were higher in NWO compared to Con (p's < 0.05).

Conclusion

In this preliminary study, adults with NWO displayed lower whole-body BMD alongside evidence of bone resorption. Impaired bone health may be another subclinical risk factor present in NWO.

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正常体重肥胖成人的全身骨密度和骨稳态指标

背景正常体重肥胖（NWO）是指体重指数（BMI）正常，但体脂百分比较高的个体。NWO有患心脏代谢疾病的风险，但对其骨骼健康知之甚少。方法将成年人（N=24）分为NWO（N=12；5M/7F）或低体脂百分比对照组（Con；N=12；6M/6F）。使用DXA评估身体成分和全身骨密度（BMD）。进行血清生物复合物测定以检查与骨形成和骨吸收相关的标志物。结果除了较高的体脂百分比和内脏脂肪外，与Con相比，NWO的全身BMD较低（p’s<；0.05）。NWO的循环瘦素高于Con（p＜0.05）。通常与较低骨量相关的两种生物标志物——硬化素和甲状旁腺激素——在NWO中高于Con。结论在本初步研究中，患有NWO的成年人显示出较低的全身BMD以及骨吸收的证据。骨健康受损可能是NWO中存在的另一个亚临床风险因素。

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Obesity Pillars

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