Tumor-targeted astaxanthin nanoparticles for therapeutic application in vitro

IF 4.7 3区材料科学 Q2 CHEMISTRY, PHYSICAL Colloid and Interface Science Communications Pub Date : 2023-07-01 DOI:10.1016/j.colcom.2023.100721

Wei Xie , Shanzhi Tan , Xiyun Ren , Jinling Yu , Chen Yang , Hongquan Xie , Zihui Ma , Ying Liu , Shucai Yang

引用次数: 1

Abstract

In recent years, with the development of molecular biology, the exploration and development of targeted drugs for cancer has gradually attracted widespread attention. Here, tumor-targeted astaxanthin nanoparticle, cRGD-PEG2000-DSPE encapsulated astaxanthin (cRGD@AST) was designed and applied for tumor therapy. Firstly, cRGD@AST can improve the water solubility of astaxanthin. Secondly, cRGD@AST can achieve tumor-targeted ability after cRGD modification and can be highly absorbed by HepG2 cells. Finally, cRGD@AST can scavenge excess ROS in tumor cells, restore the redox balance in cells, and inhibit tumor cell proliferation. It provides theoretical basis and experimental basis for the development and utilization of natural product antioxidants for cancer prevention and treatment.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

肿瘤靶向虾青素纳米颗粒的体外治疗应用

近年来，随着分子生物学的发展，癌症靶向药物的探索和开发逐渐引起广泛关注。这里，肿瘤靶向虾青素纳米颗粒，cRGD-PEG2000-DSPE封装的虾青素(cRGD@AST)设计并应用于肿瘤治疗。首先，cRGD@AST可以提高虾青素的水溶性。其次cRGD@AST在cRGD修饰后可以达到肿瘤靶向能力，并且可以被HepG2细胞高度吸收。最后cRGD@AST可以清除肿瘤细胞中过量的ROS，恢复细胞内的氧化还原平衡，抑制肿瘤细胞增殖。为开发利用天然产物抗氧化剂防治癌症提供了理论依据和实验依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Colloid and Interface Science Communications Materials Science-Materials Chemistry

CiteScore

9.40

自引率

6.70%

发文量

125

审稿时长

43 days

期刊介绍： Colloid and Interface Science Communications provides a forum for the highest visibility and rapid publication of short initial reports on new fundamental concepts, research findings, and topical applications at the forefront of the increasingly interdisciplinary area of colloid and interface science.