Adansonia digitata L. fruit shell prevents aluminum-induced cognitive impairment and depression in mice

Haruna Ahmed Usman , Samaila Musa Chiroma , Joseph Vandi Zirahei , Nathan Isaac Dibal
{"title":"Adansonia digitata L. fruit shell prevents aluminum-induced cognitive impairment and depression in mice","authors":"Haruna Ahmed Usman ,&nbsp;Samaila Musa Chiroma ,&nbsp;Joseph Vandi Zirahei ,&nbsp;Nathan Isaac Dibal","doi":"10.1016/j.bbii.2023.100014","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><p>Aluminum exposure can lead to free radicals production and increased susceptibility to lipids peroxidation in the central nervous system. The was aimed at evaluating the role of acetone extract of <em>A. digitata</em> shell acetone extract (ASAE) on oxidative stress, acetylcholinesterase (AChE) level, and hippocampal histology of aluminum chloride (AlCl3)-treated rats.</p></div><div><h3>Methods</h3><p>Twenty-five rats were allotted into five groups (n = 5). The groups received distilled water, 250 mg/kg aluminum chloride, 250 mg/kg ASAE plus AlCl3, 500 mg/kg ASAE plus AlCl3, and 200 mg/kg Vitamin C plus AlCl3 respectively once daily for sixty days. Modified elevated plus maze (mEPM) and force swim test was conducted after 24 h. One half of the rat brain was homogenized and used to evaluate AChE level and oxidative stress biomarkers while the other half was processed for light microscopy.</p></div><div><h3>Results</h3><p>Pre-treatment with ASAE was shown to significantly decrease (p &lt; .05) the first transfer latency of mEPM and immobility time of the force swim test relative to the AlCl3-treated rats. The brain AChE level was significantly increased (p &lt; .05) in rats treated with AlCl3 relative to the control. ASAE was found to regulate the AChE level. ASAE was found to significantly elevate (p &lt; .05) superoxide dismutase and catalase activity relative to the control and AlCl3-treated rats.</p></div><div><h3>Conclusions</h3><p>The findings of the current study revealed that ASAE could prevent AlCl3-induced cognitive impairment and depression. It also regulated brain AChE levels and enhanced antioxidant activity. These suggest that ASAE could serve as a natural product for preventing oxidative stress-related diseases.</p></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"2 ","pages":"Article 100014"},"PeriodicalIF":0.0000,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain Behavior and Immunity Integrative","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2949834123000132","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Purpose

Aluminum exposure can lead to free radicals production and increased susceptibility to lipids peroxidation in the central nervous system. The was aimed at evaluating the role of acetone extract of A. digitata shell acetone extract (ASAE) on oxidative stress, acetylcholinesterase (AChE) level, and hippocampal histology of aluminum chloride (AlCl3)-treated rats.

Methods

Twenty-five rats were allotted into five groups (n = 5). The groups received distilled water, 250 mg/kg aluminum chloride, 250 mg/kg ASAE plus AlCl3, 500 mg/kg ASAE plus AlCl3, and 200 mg/kg Vitamin C plus AlCl3 respectively once daily for sixty days. Modified elevated plus maze (mEPM) and force swim test was conducted after 24 h. One half of the rat brain was homogenized and used to evaluate AChE level and oxidative stress biomarkers while the other half was processed for light microscopy.

Results

Pre-treatment with ASAE was shown to significantly decrease (p < .05) the first transfer latency of mEPM and immobility time of the force swim test relative to the AlCl3-treated rats. The brain AChE level was significantly increased (p < .05) in rats treated with AlCl3 relative to the control. ASAE was found to regulate the AChE level. ASAE was found to significantly elevate (p < .05) superoxide dismutase and catalase activity relative to the control and AlCl3-treated rats.

Conclusions

The findings of the current study revealed that ASAE could prevent AlCl3-induced cognitive impairment and depression. It also regulated brain AChE levels and enhanced antioxidant activity. These suggest that ASAE could serve as a natural product for preventing oxidative stress-related diseases.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Adansonia digitata L.果壳对铝诱导的小鼠认知障碍和抑郁的预防作用
目的铝暴露可导致中枢神经系统中自由基的产生和脂质过氧化的易感性增加。目的评价A.digita壳丙酮提取物(ASAE)对氯化铝(AlCl3)处理大鼠氧化应激、乙酰胆碱酯酶(AChE)水平和海马组织学的影响。方法将25只大鼠随机分为5组(n=5)。各组分别接受蒸馏水、250 mg/kg氯化铝、250 mg/kg ASAE加AlCl3、500 mg/kg ASAE加AlCl3和200 mg/kg维生素C加AlCl3.每天一次,持续60天。24小时后进行改良的高架+迷宫(mPEM)和力泳试验。将大鼠大脑的一半匀浆并用于评估AChE水平和氧化应激生物标志物,而另一半进行光学显微镜处理。结果与AlCl3处理的大鼠相比,ASAE预处理显著降低(p<0.05)mPEM的第一次转移潜伏期和力泳试验的不动时间。与对照相比,用AlCl3处理的大鼠的脑AChE水平显著增加(p<0.05)。ASAE可调节乙酰胆碱酯酶水平。发现ASAE相对于对照和AlCl3处理的大鼠显著提高(p<0.05)超氧化物歧化酶和过氧化氢酶活性。结论ASAE可预防AlCl3引起的认知障碍和抑郁。它还调节大脑AChE水平并增强抗氧化活性。这表明ASAE可以作为一种天然产物预防氧化应激相关疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Anti-inflammatory effects of quercetin in lipopolysaccharide-activated cortical astrocytes Harmonious Healing: Advances in Music Therapy and other Alternative Therapy for Depression and Beyond The effects of exercise therapy on immune cells and function in patients with overweight or obesity: A systematic review The association between c-reactive protein and human brain microstructure: A systematic review of diffusion imaging studies Pharmacology of natural bioactive compounds used for management of Huntington diseases: An overview
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1