What Long COVID investigators can learn from four decades of ME/CFS research

Leonard A. Jason , Benjamin H. Natelson , Hector Bonilla , Zaki A. Sherif , Suzanne D. Vernon , Monica Verduzco Gutierrez , Lisa O’Brien , Emily Taylor , On behalf of the RECOVER consortium, by members of the Diagnostic Testing and Test Algorithms Subcommittee of the Commonalities with Other Post Viral Syndromes Task Force. We appreciate the edits and suggestions from Ben Z. Katz.
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Abstract

Four decades of research in the field of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) have yielded lessons that may be instructive for those devising criteria to better comprehend Post-Acute Sequelae of SARS CoV-2 Infection (PASC) and Long COVID. For instance, substantial effort has been devoted to defining classification systems, operationalizing methods, and developing instruments with adequate reliability and validity in the ME/CFS field. The current article provides guidelines for developing a case definition for Long COVID and discusses the significance of psychometric issues and criterion variance, including how to specify symptoms, and develop thresholds, subtypes, and exclusionary conditions. ME/CFS research could enhance our knowledge of Long COVID pathophysiology, early diagnosis, prognosis, and the identification of effective treatments.

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COVID调查人员可以从40年的ME/CFS研究中学到什么
四十年来,在肌痛性脑脊髓炎/慢性疲劳综合征(ME/CFS)领域的研究得出了一些经验教训,这些经验教训可能对那些制定标准以更好地理解严重急性呼吸系统综合征冠状病毒2型感染后后遗症(PASC)和长期新冠肺炎的人具有指导意义。例如,在脑脊髓炎/慢性疲劳综合征领域,为定义分类系统、实施方法和开发具有足够可靠性和有效性的工具付出了大量努力。目前的文章提供了制定长期新冠肺炎病例定义的指南,并讨论了心理测量问题和标准差异的重要性,包括如何指定症状,以及制定阈值、亚型和排除性条件。脑脊髓炎/慢性疲劳综合征的研究可以增强我们对长期新冠肺炎病理生理学、早期诊断、预后和有效治疗方法的认识。
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