Microglia in the pathogenesis of depression, insomnia and their comorbidity

Fanglin Liu , Dan Guo , Teng Gao , Mengqi Diao , Ying Han
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Abstract

Microglia have been shown to regulate sleep homeostasis and depressive behavior. However, the mechanism of how microglia are involved in the pathogenesis of depression and insomnia is not well understood. Given the complex and interdependent relationship between sleep and depression, it is important and worthy to clarify the role of microglia in this comorbidity. This review summarizes the current understandings of microglia in insomnia and depression, as well as suggesting their shared mechanisms in neuroinflammation, synaptic plasticity and purinergic signaling, which may promote the precise treatment of comorbid insomnia and depression and facilitate early intervention of insomnia to prevent the onset of depression.

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小胶质细胞在抑郁症、失眠的发病机制及其合并症中的作用
小胶质细胞已被证明可以调节睡眠稳态和抑郁行为。然而,小胶质细胞如何参与抑郁症和失眠的发病机制尚不清楚。鉴于睡眠和抑郁症之间复杂而相互依存的关系,阐明小胶质细胞在这种共病中的作用是重要和有价值的。这篇综述总结了目前对小胶质细胞在失眠和抑郁中的理解,并提出了它们在神经炎症、突触可塑性和嘌呤能信号传导方面的共同机制,这可能有助于精确治疗失眠和抑郁共病,并有助于失眠的早期干预以预防抑郁的发作。
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