A silicone with one quaternary ammonium salt and three N-halamine sites in the repeating unit for improved antibiotic ability on submicrospheres

IF 4.7 3区材料科学 Q2 CHEMISTRY, PHYSICAL Colloid and Interface Science Communications Pub Date : 2023-09-01 DOI:10.1016/j.colcom.2023.100731

Yujiao Hao , Shun Liu , Hongtan Cai , Qiaoyi Zhang , Ge Gao , Xiufeng Hao

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Abstract

A silicone containing one cationic quaternary ammonium salt (QAS) and three N-halamine sites in the repeating unit was developed on SiO₂ submicron spheres for better antibacterial performance, larger bactericidal area and easier recyclability. Briefly, a precursor (NDAM) with high content of N-halamine was prepared by the amidation reaction. Then, a SiO₂@NDA nanocomposite was synthesized. Chlorination of the three imide NH bonds in the repeat unit finalized the synthesis of the bactericidal silicone (SiO₂@NDA-Cl). The synthetic steps and products were characterized and the effect of the contents of NDAM in copolymer on antibacterial activity were systematically assayed. The SiO₂@NDA-Cl showed higher deactivation abilities against both E. coli and S. aureus compared with their counterparts that contained only one cationic center or one N-halamine. This study has theoretical and practical application value for the development of new antibacterial materials.

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在重复单元中具有一个季铵盐和三个n -卤胺位点的有机硅，用于改善亚微球上的抗生素能力

在SiO2亚微米球上开发了一种重复单元中含有一个阳离子季铵盐（QAS）和三个N-卤胺位点的有机硅，以获得更好的抗菌性能、更大的杀菌面积和更容易回收的性能。简单地说，通过酰胺化反应制备了高含量N-卤胺的前体（NDAM）。然后SiO2@NDA合成了纳米复合材料。重复单元中三个酰亚胺NH键的氯化最终完成了杀菌有机硅的合成(SiO2@NDA-Cl)。对合成步骤和产物进行了表征，并系统地测定了共聚物中NDAM含量对抗菌活性的影响。这个SiO2@NDA-Cl与仅含有一个阳离子中心或一个N-卤胺的对应物相比，对大肠杆菌和金黄色葡萄球菌都显示出更高的失活能力。本研究对开发新型抗菌材料具有理论和实际应用价值。

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来源期刊

Colloid and Interface Science Communications Materials Science-Materials Chemistry

CiteScore

9.40

自引率

6.70%

发文量

125

审稿时长

43 days

期刊介绍： Colloid and Interface Science Communications provides a forum for the highest visibility and rapid publication of short initial reports on new fundamental concepts, research findings, and topical applications at the forefront of the increasingly interdisciplinary area of colloid and interface science.