Gellan gum and sodium alginate in-situ gel of monocaprin for effective corneal permeation

IF 4.6 Q1 CHEMISTRY, APPLIED Food Hydrocolloids for Health Pub Date : 2023-09-12 DOI:10.1016/j.fhfh.2023.100156
Sumon Giri , Tanmay S Markandeywar , Zainab Irfan , Sreejan Manna
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Abstract

Babies born to mothers suffering from gonorrhea may experience severe eye infections that might culminate in loss of vision. The eyes of the neonate can are infected with Neisseria gonorrhoeae, during birth. The primary goal of the study was to develop a stable aqueous ion-activated polymeric solution with clinically useful amounts of fatty acid-based monocaprin and a polymeric mixture of two commonly employed edible polysaccharide, sodium alginate and gellan gum. Monocaprin is an antibacterial agent against the treatment of gonococcal ophthalmia neonatorum, which was successfully formulated as an ion-activated in-situ gel-forming ophthalmic solution. The absence of drug-polymer interaction was confirmed from the FTIR study. The gelling capacity confirmed pH dependent (pH 7.2–7.4) sol-to-gel transition at 37°C±0.5°C. Formulation C4 was selected as the best formulation because it exhibited clear appearance, pH, good gelling capacity, optimum viscosity, 96.4% in-vitro drug release up to 11h. Formulation C4 also exhibited 96.6% drug release after 12h using goat cornea. The study results demonstrated remarkable enhancement in corneal permeation of in-situ gel in contrast to conventional eye drops. Sterility results showed no evidence of bacterial growth after 14 days in different media. The developed monocaprin incorporated sodium alginate and gellan gum based in situ gel formulation showed promising results with increased ocular residence and enhanced corneal permeability.

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结冷胶和海藻酸钠原位凝胶对单紫杉醇的有效角膜渗透
患有淋病的母亲所生的婴儿可能会经历严重的眼部感染,最终可能导致视力丧失。新生儿的眼睛在出生时可能感染淋病奈瑟菌。该研究的主要目标是开发一种稳定的离子活化聚合物水溶液,其中含有临床上有用量的基于脂肪酸的单核霉素和两种常用食用多糖(藻酸钠和结冷胶)的聚合物混合物。Monocaprin是一种治疗新生儿淋球菌性眼炎的抗菌剂,已成功配制成离子活化原位凝胶眼用溶液。FTIR研究证实了不存在药物-聚合物相互作用。胶凝能力证实了在37°C±0.5°C时pH依赖性(pH 7.2–7.4)的溶胶-凝胶转变。配方C4被选为最佳配方,因为它表现出清晰的外观、pH、良好的胶凝能力、最佳粘度、96.4%的体外药物释放长达11小时。配方C4在使用山羊角膜12小时后也表现出96.6%的药物释放。研究结果表明,与传统滴眼液相比,原位凝胶的角膜渗透性显著增强。无菌结果显示在不同培养基中14天后没有细菌生长的迹象。所开发的含有海藻酸钠和结兰胶的莫卡必林原位凝胶制剂显示出良好的效果,增加了眼睛停留时间,增强了角膜通透性。
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CiteScore
4.50
自引率
0.00%
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0
审稿时长
61 days
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