Liposome mediated encapsulation and role of chitosan on modulating liposomal stability to deliver potential bioactives-A review

IF 4.6 Q1 CHEMISTRY, APPLIED Food Hydrocolloids for Health Pub Date : 2023-06-23 DOI:10.1016/j.fhfh.2023.100142

Jean Mary Joy , Amruth P , Rosemol Jacob M , Pavan Kumar Dara , V. Renuka , R. Anandan

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引用次数: 1

Abstract

Liposomes are amphiphilic structures widely explored for the encapsulation of various active ingredients in the area of pharmaceutics, cosmetics and numerous others. Wherein, the conventional liposomal structure is found to possess certain drawbacks with regard to their stability and release kinetics of active ingredients. Chitosan is a natural polysaccharide that exhibits structural stability, excellent biocompatibility, biodegradability, flexibility, non-immunogenicity and targetability. Coating of chitosan to liposomes have found to modulate the bio functionality of liposome vesicles in terms of stability and release kinetics and therefore chitosan coated liposomes (chitosomes) remain as efficient carrier to transport potential bioactives to the targeted sites effectively. This review highlights the liposomal mediated encapsulation methods and induces insights to employ modulation of liposomal stability by chitosan coating to liposomes for the facile transport of active ingredients for multiple applications.

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脂质体介导的包封及壳聚糖在调节脂质体稳定性传递潜在生物活性中的作用综述

脂质体是两亲性结构，在制药、化妆品和许多其他领域被广泛探索用于封装各种活性成分。其中，发现常规脂质体结构在活性成分的稳定性和释放动力学方面具有某些缺点。壳聚糖是一种天然多糖，具有结构稳定性、良好的生物相容性、生物降解性、柔韧性、非免疫原性和靶向性。壳聚糖与脂质体的包被已发现在稳定性和释放动力学方面调节脂质体囊泡的生物功能，因此壳聚糖包被的脂质体（壳体）仍然是将潜在的生物活性物质有效转运到靶位点的有效载体。这篇综述强调了脂质体介导的包封方法，并引入了通过壳聚糖涂层调节脂质体稳定性的见解，以便于将活性成分运输到多种应用中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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