An injectable macroporous hydrogel templated by gasification reaction for enhanced tissue regeneration

You Zhou , Mingshuo Cui , Shenglong Liao , Bin Yuan , Rui Shi , Xiaohua Hu , Yapei Wang
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引用次数: 2

Abstract

Owing to excellent biocompatibility, tunable modulus to match biological tissues, full of water environment, and wide range of constituents, injectable hydrogels have always been preferred as superior performers of regenerative medicine. In principle, the inclusion of macroporous structures in hydrogels facilitates the diffusion of oxygen and nutrients for cell survival and the removal of the metabolic waste, thus strengthening the integration between materials and host tissues. So far, it is still a challenge to construct macroporous structure in hydrogels in situ with preservation of mechanical strength after injecting hydrogel precursors into the biological tissues. In this study, we propose an innovative in situ gas-forming strategy for preparing a kind of bioactive injectable macroporous hydrogel with the assistance of Mg microparticles (MgMPs). Hydrogen gas as a product of MgMPs reacting with water acts as porous template during the gelation process. So the porosity is closely related to the amount of MgMPs, which is a crucial factor for improving cell viability and proliferation throughout the macroporous hydrogel. Referring to the in vivo wound care experiments, regenerated epidermis and extensive blood vessels are found in the macroporous hydrogel, indicating enhanced tissue regeneration. This in situ gas-templating strategy for preparing injectable macroporous hydrogels holds promise as a technique for providing improved biological scaffolds.

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一种可注射的经气化反应模板化的大孔水凝胶,用于增强组织再生
由于优异的生物相容性、可调节的模量以匹配生物组织、充满水的环境和广泛的成分,注射水凝胶一直是再生医学的首选。原则上,水凝胶中包含大孔结构有助于氧气和营养物质的扩散,以促进细胞存活和代谢废物的去除,从而加强材料和宿主组织之间的整合。到目前为止,在将水凝胶前体注射到生物组织中后,在原位构建水凝胶大孔结构并保持机械强度仍然是一个挑战。在本研究中,我们提出了一种创新的原位气体形成策略,用于在镁微粒(MgMP)的辅助下制备一种具有生物活性的可注射大孔水凝胶。氢气作为MgMP与水反应的产物,在凝胶化过程中充当多孔模板。因此,孔隙率与MgMP的量密切相关,MgMP是提高整个大孔水凝胶中细胞活力和增殖的关键因素。参考体内伤口护理实验,在大孔水凝胶中发现了再生的表皮和广泛的血管,表明组织再生增强。这种用于制备可注射大孔水凝胶的原位气体模板策略有望成为一种提供改进的生物支架的技术。
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