Sensitive and selective electrochemical sensor for the detection of dopamine by using AuPd@Fe2O3 nanoparticles as catalyst

Advanced Sensor and Energy Materials Pub Date : 2023-03-01 DOI:10.1016/j.asems.2023.100048

Mengjiao Dai , Qunyan Zhu , Dongxue Han , Li Niu , Zhenxin Wang

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引用次数: 1

Abstract

The levels of dopamine (DA) in living organisms have strong effects on many biological processes and diseases, such as Parkinson's disease and Alzheimer's disease. Therefore, it has great significance for sensitive and selective detection of DA. Herein, the AuPd@Fe₂O₃ nanoparticles-based electrochemical (EC) sensor (AuPd@Fe₂O₃ NPs/GCE) is developed for chronoamperometric detection of DA with high sensitivity and good anti-interference ability through simple immobilization of AuPd@Fe₂O₃ nanoparticles on glassy carbon electrode (GCE) by Nafion. Under the application of oxidation potential, the AuPd@Fe₂O₃ NPs/GCE exhibits good electrocatalytic activity toward DA, which enables to linearly detect DA in the range of 10 nM–831.61 μM (R² = 0.9983). The AuPd@Fe₂O₃ NPs/GCE also shows good selectivity and reproducibility for the detection of DA. Furthermore, the practicability of AuPd@Fe₂O₃ NPs/GCE has been demonstrated by detection of DA in dopamine hydrochloride injection and human serum.

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以AuPd@Fe2O3纳米颗粒为催化剂的灵敏选择性电化学传感器

生物体中多巴胺（DA）的水平对许多生物过程和疾病有着强烈的影响，如帕金森病和阿尔茨海默病。因此，对DA的灵敏、选择性检测具有重要意义AuPd@Fe2O3基于纳米颗粒的电化学（EC）传感器(AuPd@Fe2O3NPs/GCE）是为DA的计时电流检测而开发的，通过简单的固定化，具有高灵敏度和良好的抗干扰能力AuPd@Fe2O3纳米颗粒在玻碳电极（GCE）上的Nafion。在氧化电位的作用下AuPd@Fe2O3NPs/GCE对DA具有良好的电催化活性，能够在10 nM–831.61μM范围内线性检测DA（R2=0.9983）AuPd@Fe2O3NPs/GCE对DA的检测也显示出良好的选择性和重现性AuPd@Fe2O3NPs/GCE已通过检测盐酸多巴胺注射液和人血清中的DA得到证实。

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Advanced Sensor and Energy Materials

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