Advanced Sensor and Energy Materials最新文献

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Corrigendum to “Needle−tip effect promoted flexible electrochemical sensor for detecting chloride ions in food by in−situ deposited silver dendrimers” [Adv Sensor Energy Mater 3 (2024) 100100]

Advanced Sensor and Energy Materials

Pub Date : 2025-03-10 DOI: 10.1016/j.asems.2024.100130

Huang Dai , Huilin Hu , Zhiyong Gong , Jing Shu , Jiahua Wang , Xiaodan Liu , Fuwei Pi , Qiao Wang , Shuo Duan , Yingli Wang

引用次数: 0

Design, development and testing of a wearable hybrid energy harvester for sustainable gadgets

Advanced Sensor and Energy Materials

Pub Date : 2025-01-21 DOI: 10.1016/j.asems.2025.100137

Abdulla Alsaad, Iftikhar Ahmad, Adel Aawan, Ahmed M. Abdelrhman, Wajid Khan

This research paper presents the design, development and testing of a novel wearable hybrid energy harvester (WH-EH) aimed at powering sustainable gadgets. By harnessing energy using both electromagnetic and piezoelectric transduction mechanisms to capture ambient mechanical energy from human body motion, this device offers a versatile solution to the growing demand for portable and renewable energy. The paper details the integration of both mechanisms into a single device that fits in human shoes and the practical implications of deploying such technology in everyday gadgets. The WH-EH comprised of 3D printed frame, a cantilever beam made up of stainless steel, two permanent neodymium magnets residing at the tip of the cantilever beam, two printed circuit board-based micro planar coils that were fixed to the top and bottom of the 3D printed frame. Through rigorous testing, the WH-EH has demonstrated significant potential of producing maximum a power of 577 μW which can help in reducing the reliance on traditional power sources and advancing the frontier of wearable technology. Energy harvesters like WH-EH are pivotal in advancing the sustainability of wearable gadgets, diminishing the dependence on traditional battery sources. These innovations not only strengthen the longevity and eco-friendliness of personal electronics but also align with global sustainable development goals, particularly in the energy and environmental sectors. The progression of such energy harvesters marks a crucial milestone in the ongoing integration of renewable energy practices into daily electrical applications.

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引用次数: 0

Recent applications and challenges of inorganic nanomaterial-based biosensing devices for detecting nucleic acid biomarkers

Advanced Sensor and Energy Materials

Pub Date : 2025-01-20 DOI: 10.1016/j.asems.2025.100136

Yitian Tang , Qunmei Zhang , Hongchang Yuan , Xiaoyin Wang , Liuyang Xu , Guoqiang Wang , Min Zhang , Ping Lu , Hua Zhong , Yihan Wang

Nucleic acids are specific biomolecules for clinically relevant diseases. Highly sensitive detection of these low-abundance biomolecules is essential for understanding their functions in disease diagnosis, prognosis, and predicting treatment effects. As a traditional detection method, polymerase chain reaction (PCR) has high sensitivity. However, it is time-consuming and requires complex experimental equipment, which limits its application in on-site rapid detection. To address these issues, biosensing devices based on inorganic nanomaterials (INMs) have been widely used to detect nucleic acid biomarkers in recent years. Compared with organic or polymer nanomaterials, INMs have unique physical and chemical properties that produce synergistic effects regarding biocompatibility, electrical conductivity, and high specific surface area. It can also amplify the signal by increasing the signal tag loading, making it ideal for biosensing devices. This article reviews the latest progress of INMs (metal nanoparticles, metal oxide nanomaterials, carbon-based nanomaterials, quantum dots, magnetic nanomaterials) in nucleic acid detection and introduces the definition, specific effects, and synthesis of INMs. Subsequently, the applications of INMs integrated into various sensing platforms were discussed, including electrochemical biosensors, electrochemiluminescence (ECL) biosensors, photoelectrochemical (PEC) biosensors, and self-powered biosensor and point-of-care testing (POCT) to achieve highly sensitive and specific detection of nucleic acid molecules such as DNA and RNA. Finally, the opportunities and challenges faced by biosensing devices based on INMs in the future development of nucleic acid detection are discussed and prospected.

核酸是临床相关疾病的特异性生物分子。高灵敏度地检测这些低丰度的生物大分子对于了解它们在疾病诊断、预后和预测治疗效果方面的功能至关重要。作为一种传统的检测方法，聚合酶链反应（PCR）具有很高的灵敏度。然而，聚合酶链反应耗时长，实验设备要求复杂，限制了其在现场快速检测中的应用。为解决这些问题，近年来基于无机纳米材料（INM）的生物传感设备已被广泛用于检测核酸生物标记物。与有机或高分子纳米材料相比，INMs 具有独特的物理和化学特性，在生物相容性、导电性和高比表面积方面具有协同效应。它还能通过增加信号标签负载来放大信号，因此是生物传感设备的理想选择。本文综述了 INMs（金属纳米颗粒、金属氧化物纳米材料、碳基纳米材料、量子点、磁性纳米材料）在核酸检测中的最新进展，介绍了 INMs 的定义、特异性效应和合成。随后，讨论了将 INMs 集成到各种传感平台中的应用，包括电化学生物传感器、电化学发光（ECL）生物传感器、光电化学（PEC）生物传感器以及自供电生物传感器和护理点检测（POCT），以实现对 DNA 和 RNA 等核酸分子的高灵敏度和特异性检测。最后，讨论并展望了基于 INMs 的生物传感设备在未来核酸检测发展中所面临的机遇和挑战。

{"title":"Recent applications and challenges of inorganic nanomaterial-based biosensing devices for detecting nucleic acid biomarkers","authors":"Yitian Tang , Qunmei Zhang , Hongchang Yuan , Xiaoyin Wang , Liuyang Xu , Guoqiang Wang , Min Zhang , Ping Lu , Hua Zhong , Yihan Wang","doi":"10.1016/j.asems.2025.100136","DOIUrl":"10.1016/j.asems.2025.100136","url":null,"abstract":"<div><div>Nucleic acids are specific biomolecules for clinically relevant diseases. Highly sensitive detection of these low-abundance biomolecules is essential for understanding their functions in disease diagnosis, prognosis, and predicting treatment effects. As a traditional detection method, polymerase chain reaction (PCR) has high sensitivity. However, it is time-consuming and requires complex experimental equipment, which limits its application in on-site rapid detection. To address these issues, biosensing devices based on inorganic nanomaterials (INMs) have been widely used to detect nucleic acid biomarkers in recent years. Compared with organic or polymer nanomaterials, INMs have unique physical and chemical properties that produce synergistic effects regarding biocompatibility, electrical conductivity, and high specific surface area. It can also amplify the signal by increasing the signal tag loading, making it ideal for biosensing devices. This article reviews the latest progress of INMs (metal nanoparticles, metal oxide nanomaterials, carbon-based nanomaterials, quantum dots, magnetic nanomaterials) in nucleic acid detection and introduces the definition, specific effects, and synthesis of INMs. Subsequently, the applications of INMs integrated into various sensing platforms were discussed, including electrochemical biosensors, electrochemiluminescence (ECL) biosensors, photoelectrochemical (PEC) biosensors, and self-powered biosensor and point-of-care testing (POCT) to achieve highly sensitive and specific detection of nucleic acid molecules such as DNA and RNA. Finally, the opportunities and challenges faced by biosensing devices based on INMs in the future development of nucleic acid detection are discussed and prospected.</div></div>","PeriodicalId":100036,"journal":{"name":"Advanced Sensor and Energy Materials","volume":"4 1","pages":"Article 100136"},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aptamer-based biosensors for biogenic amines detection

Advanced Sensor and Energy Materials

Pub Date : 2025-01-18 DOI: 10.1016/j.asems.2025.100135

Min Yang , Yushi Xie , Longjiao Zhu , Ran Wang , Jie Zheng , Wentao Xu

Biogenic amines (BAs) are a class of small nitrogen-containing organic compounds commonly found in various foods and are one of the common metabolic by-products in the process of food spoilage. When consumed in excessive amounts by the human body, BAs can cause a range of adverse reactions such as difficulty in breathing and palpitations, posing a serious threat to life and health. Moreover, the content of BAs is closely related to the degree of food spoilage, making them an important indicator for measuring food quality and freshness. Therefore, accurate detection of BAs is particularly important. Aptamer biosensors are becoming more and more important in the field of biosensing and show great potential. In this review, we first systematically summarized the structural characteristics, formation mechanism and potential toxicity of BAs. Then, the screening strategies and methods of biogenic amine aptamers were discussed. On this basis, we focus on the latest progress in the field of aptamer sensor technology for BAs detection in food and divide these technologies into four categories according to the detection principle: colorimetric analysis, fluorescence detection, surface-enhanced Raman spectroscopy (SERS) analysis and electrochemical detection. Finally, the future development direction and current challenges of biogenic amine detection strategies are introduced.

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引用次数: 0

Optical fiber sensor solutions for in-situ transmittance control of electrochromic glazing

Advanced Sensor and Energy Materials

Pub Date : 2025-01-10 DOI: 10.1016/j.asems.2025.100134

Ingemar Petermann , Magnus Lindblom , Carola Sterner , Greger Gregard , Stefan Karlsson

Windows are essential to let natural daylight into our buildings. Smart and dynamic glazing is an important technology for achieving sustainable and energy-efficient buildings with good indoor environment by reducing the need for air-conditioning. Electrochromic glazing is the commercial state-of-the-art for smart and dynamic glazing. In principle electrochromic glazing works like a thin film battery, whose lifetime is enhanced if the combination of elevated temperature and a high state-of-charge, or low light transmittance, are avoided. Therefore, a direct transmittance measurement is desirable. In this study, we have evaluated four different methods using optical fibers, whereof two methods were found to work well, both in initial testing and when compared to reference transmittance cycling measurements. Both methods relied on light from a light emitting diode, at 810 nm wavelength, that was propagated either through the electrochromic foil or along it. The latter shows most potential to be implemented in a manufacturing process of smart glazing.

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引用次数: 0

DNA-templated fabrication of metal nanostructures with special shapes

Advanced Sensor and Energy Materials

Pub Date : 2024-12-30 DOI: 10.1016/j.asems.2024.100133

Shaokang Ren , Lei Ren , Biancheng Wei , Yubo Liu , Jianzhong Yang , Jiang Li , Lihua Wang

Metal structures with special shapes at the length scales of electromagnetic waves, particularly visible light (∼10^–⁷ m), hold great promise in the development of next-generation electronic/optical devices. However, downscaling the metal structure features to the sub-10 nm scale remains a challenge due to the resolution limitations inherent in conventional top-down microfabrication techniques. In recent years, DNA nanotechnology has garnered significant attention due to its capability to construct nanostructures with programmable shapes at the nanometer scale, which can serve as templates for the fabrication of metal nanostructures. Here, we review the development of DNA-templated metal nanostructures with unique shapes, focusing on their electronic and optical properties and applications. We discuss the advantages and limitations of these strategies and provide an outlook for this research area.

引用次数: 0

Non-thiolated spherical nucleic acids for biosensors and assembly of nanomaterials

Advanced Sensor and Energy Materials

Pub Date : 2024-12-14 DOI: 10.1016/j.asems.2024.100132

Xin Wang , Stefen Stangherlin , Nan Cheng , Juewen Liu

Spherical nucleic acids (SNAs) refer to a nanoparticle core decorated with a high density of single-stranded DNA or RNA. SNAs have garnered significant attention for their unique physicochemical properties and advantages in biomedical, nanotechnology and biosensing applications. The preparation of traditional SNAs typically relies on the strong bonding between thiolated DNA and gold nanoparticles (AuNPs) to ensure a high-density and stable DNA attachment. Interestingly, non-thiolated DNA also strongly interacts with gold surfaces through the coordination of its nucleobases, enabling the preparation of cost-effective non-thiolated SNAs. In this review, we introduce the adsorption properties of DNA on AuNPs, followed by a review of the current methods for the synthesis of non-thiolated SNAs and a discussion of their stability based on existing data. The reviewed methods include salt-aging, low-pH, freezing, microwaving, and thermal drying. Most methods rely on a poly-adenine block to anchor onto the surface of AuNPs. Furthermore, two types of non-thiolated SNA products are discussed, which are characterized by their DNA density as a function of the length of the poly-adenine block. Finally, we briefly outline the current applications of SNAs, including biosensing and DNA-directed assembly, and discuss potential future developments.

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引用次数: 0

Utilizing framework nucleic acids for integrated nano-micro interface system in circulating tumor cells (CTCs) detection, cultivation, and single-cell analysis

Advanced Sensor and Energy Materials

Pub Date : 2024-12-10 DOI: 10.1016/j.asems.2024.100131

Qian Chen , Jie Su , Xiaojun Bian, Hongmin Zhang, Shiqi Yang, Juan Yan

The detection and cultivation of circulating tumor cells (CTCs) play a crucial role in monitoring tumor recurrence, metastasis, early disease diagnosis, and assessing the effectiveness of drug treatments. This study specifically focused on investigating human breast cancer cells MCF-7 by utilizing framework nucleic acids (FNAs) as bio-probe scaffold in conjunction with fishbone structures and three-dimensional (3D) microcavity structures within microchannels. These components collectively formed an integrated nano-micro interface system designed for a comprehensive examination of CTC detection and cell culture. The study involved the assessment and comparison of rigid 3D FNAs with distinct side lengths of 7, 13, and 26 bases. This approach not only allowed for precise regulation of the DNA biosensor interface through the manipulation of probe spacing, facilitating optimal probe-cell interactions within the microfluidic channel. Consequently, this approach significantly enhances capture efficiency and lowers the CTC detection limit to 5 cells/mL. Moreover, this research successfully observed cell proliferation and individual cell biological behavior within the 3D microcavity structure. The findings indicated that the overall cell population's proliferation was like that in static culture conditions. Although the proliferation cycle of individual cells was notably extended, cell mobility within the microcavity demonstrated their robust biological activity. These significant outcomes not only offer a practical approach for early tumor detection but also provide a valuable pathway for comprehending mechanisms of tumor development and advancement and guiding personalized treatment strategies effectively.

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引用次数: 0

Palladium–iridium nanocubes modified with a high-affinity DNA aptamer as paired viral diagnostic and therapeutic tools

Advanced Sensor and Energy Materials

Pub Date : 2024-10-30 DOI: 10.1016/j.asems.2024.100125

Rudi Liu , Jiuxing Li , Jimmy Gu , Bruno J. Salena , Yingfu Li

The COVID-19 pandemic emphasizes the need for the development of molecular tools that can be used as effective diagnostic and therapeutic agents. Herein we investigate the potential of aptamer-dressed nanomaterials both as diagnostics and therapeutics using SARS-CoV-2 as a model. The nanomaterials are based on the palladium-iridium (Pd–Ir) nanocubes modified with monomeric, dimeric or trimeric aptamers that exhibit varying affinities for the spike protein of SARS-CoV-2. These nanomaterials were first examined for diagnostic potential through the creation of a nanozyme-linked aptamer assay (NLAA) that takes advantage of the peroxidase-mimicking activity of Pd–Ir nanocubes. The trimeric aptamer-based NLAA demonstrated a limit of detection (LOD) of 9.3×10³ cp/mL for pseudoviruses expressing the spike protein of SARS-CoV-2, 172- and 12.9-fold lower than that of the monomeric and dimeric aptamer-based NLAAs, respectively. Upon testing with 60 clinical saliva samples, the trimeric aptamer-based NLAA achieved a specificity of 100% and a sensitivity of 86.7%. The same nanomaterials were also examined for the ability to block viral entry to host cells. The trimeric aptamer-conjugated nanocubes exhibited a superior neutralizing ability, with an IC₅₀ value of 6.4 pM, 2.7-fold and 10.1-fold lower than that of the dimeric and monomeric aptamer nanocubes. Moreover, the trimeric aptamer-conjugated nanocubes exhibited excellent biostability and biocompatibility. Overall, our study provides a framework for combating future viral pandemics through the development of a paired biosensor and neutralizing agent made of the same aptamer-modified nanomaterial that recognizes an important viral surface protein like the spike protein of SARS-CoV-2.

{"title":"Palladium–iridium nanocubes modified with a high-affinity DNA aptamer as paired viral diagnostic and therapeutic tools","authors":"Rudi Liu , Jiuxing Li , Jimmy Gu , Bruno J. Salena , Yingfu Li","doi":"10.1016/j.asems.2024.100125","DOIUrl":"10.1016/j.asems.2024.100125","url":null,"abstract":"<div><div>The COVID-19 pandemic emphasizes the need for the development of molecular tools that can be used as effective diagnostic and therapeutic agents. Herein we investigate the potential of aptamer-dressed nanomaterials both as diagnostics and therapeutics using SARS-CoV-2 as a model. The nanomaterials are based on the palladium-iridium (Pd–Ir) nanocubes modified with monomeric, dimeric or trimeric aptamers that exhibit varying affinities for the spike protein of SARS-CoV-2. These nanomaterials were first examined for diagnostic potential through the creation of a nanozyme-linked aptamer assay (NLAA) that takes advantage of the peroxidase-mimicking activity of Pd–Ir nanocubes. The trimeric aptamer-based NLAA demonstrated a limit of detection (LOD) of 9.3×10<sup>3</sup> cp/mL for pseudoviruses expressing the spike protein of SARS-CoV-2, 172- and 12.9-fold lower than that of the monomeric and dimeric aptamer-based NLAAs, respectively. Upon testing with 60 clinical saliva samples, the trimeric aptamer-based NLAA achieved a specificity of 100% and a sensitivity of 86.7%. The same nanomaterials were also examined for the ability to block viral entry to host cells. The trimeric aptamer-conjugated nanocubes exhibited a superior neutralizing ability, with an IC<sub>50</sub> value of 6.4 pM, 2.7-fold and 10.1-fold lower than that of the dimeric and monomeric aptamer nanocubes. Moreover, the trimeric aptamer-conjugated nanocubes exhibited excellent biostability and biocompatibility. Overall, our study provides a framework for combating future viral pandemics through the development of a paired biosensor and neutralizing agent made of the same aptamer-modified nanomaterial that recognizes an important viral surface protein like the spike protein of SARS-CoV-2.</div></div>","PeriodicalId":100036,"journal":{"name":"Advanced Sensor and Energy Materials","volume":"4 2","pages":"Article 100125"},"PeriodicalIF":0.0,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143705857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Redox-active sp2-c connected metal covalent organic frameworks for selective detection and reductive separation of uranium 用于选择性检测和还原分离铀的氧化还原活性 sp2-c 连接金属共价有机框架

Advanced Sensor and Energy Materials

Pub Date : 2024-09-02 DOI: 10.1016/j.asems.2024.100124

Jin-Lan Liu , Zhi-Hai Peng , Jia-Xin Qi , Cheng-Rong Zhang , Zhen-Wen Zhang , Li Zhang , Ru-Ping Liang , Jian-Ding Qiu

It is economically desirable to develop a material that can simultaneously detect and recover uranium. Herein, a CC-bridged two-dimensional metal-covalent organic framework (Cu-BTAN-AO MCOF) was constructed by condensation of metal single crystals with a rigid structure (Cu₃(PyCA)₃) and cyano monomers (BTAN) via Knoevenagel reaction for simultaneous detection and adsorption of uranium. The amidoxime group within the pore and the presence of unsaturated Cu(I) in the framework facilitate the adsorption of uranyl ions onto the amidoxime group, leading to fluorescence quenching via the photoinduced electron transfer (PET) mechanism, achieving a detection limit of as low as 167 nM uranyl ions. Furthermore, Cu-BTAN-AO demonstrates exceptional efficiency in capturing uranium from wastewater characterized by rapid kinetics and superior selectivity. It is noteworthy that Cu-BTAN-AO is the first example of simultaneous detection, adsorption and chemical reduction of uranium using metal centers and functional groups in MCOF, indicating that Cu-BTAN-AO has great potential for the detection and recovery of uranium-containing wastewater. This design strategy may also be applicable to advancing sensing and energy materials for other important metal ions.

开发一种可同时检测和回收铀的材料具有经济上的可取性。在此，通过克诺文纳格尔反应，将具有刚性结构的金属单晶（Cu3(PyCA)3）与氰基单体（BTAN）缩合，构建了一种 CC 桥接的二维金属-共价有机框架（Cu-BTAN-AO MCOF），可同时检测和吸附铀。孔隙中的脒肟基团和框架中存在的不饱和 Cu（I）促进了铀酰离子对脒肟基团的吸附，从而通过光诱导电子转移（PET）机制导致荧光淬灭，实现了低至 167 nM 的铀酰离子检测限。此外，Cu-BTAN-AO 在捕获废水中的铀方面表现出卓越的效率，其特点是快速的动力学和出色的选择性。值得注意的是，Cu-BTAN-AO 是利用 MCOF 中的金属中心和官能团同时检测、吸附和化学还原铀的第一个实例，这表明 Cu-BTAN-AO 在检测和回收含铀废水方面具有巨大潜力。这种设计策略也可用于推进其他重要金属离子的传感和能源材料。

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