Understanding the dynamics of inflammatory mediators in response to mind-body movement therapies (MBMTs): A systematic review and meta-analysis of studies in healthy subjects

Dennis Muñoz-Vergara , Wren Burton , Paul Bain , Pamela M. Rist , Sat Bir S. Khalsa , Kristin L. Schreiber , Peter M. Wayne , Gloria Y. Yeh
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引用次数: 1

Abstract

Background

Modulation of inflammation has been proposed as a potentially important aspect of mind-body movement therapies (MBMTs). Research from the sports medicine has delineated the inflammatory cascade after conventional exercise; however, relatively less is known regarding modulation of inflammation after MBMTs.

Objective

To synthesize the available literature investigating the short- and long-term impact of MBMT interventions on systemic inflammatory mediators in healthy individuals.

Methods

We conducted a systematic review and meta-analysis of inflammatory mediators according to Preferred Reporting Items for Systematic Review and Meta-Analyses Guidelines. We sought RCTs in healthy individuals comparing MBMTs with passive or active controls that measured systemic inflammatory markers. We used the Cochrane risk-of-bias tool for randomized trials. Hedges’s g and 95% CIs were computed across studies.

Results

Of 3122 studies identified, 23 were eligible for synthesis. Most common MBMTs studied were yoga(n = 11), qigong(n = 4), tai chi(n = 3), MBSR(n = 3), and dance therapy(n = 2). Frequency of practice (most commonly 3 times/week), intervention duration (3 short-term, single session and 20 long-term with repeated sessions for>1 week), and session length (most commonly 30–60 min) showed high heterogeneity between studies. Pro- and anti-inflammatory proteins were most commonly measured (n = 20 studies), followed by immune cells (n = 5), lipid mediators (n = 4), and humoral and complement factors (n = 2). Most showed no change or decrease in inflammatory mediators, with fewer showing increased levels. Meta-analyses suggested a significant decrease in systemic levels of CRP (Hedges’s g = −0.351; CI = −0.580, −0.123) and TNF-α (Hedges’s g = −0.366; CI = −0.669, −0.064), and a trend toward decreased IL-6 after long-term MBMTs (Hedges’s g = −0.394; CI = −0.819, 0.030).

Conclusion

While findings suggest inflammatory proteins, including CRP, TNF-α, and IL-6 decrease with long-term MBMTs similar to conventional exercise, the overall trajectory of change in inflammatory mediators after MBMT may be more nuanced. Future carefully-controlled studies including precise intervention parameters evaluating pre-post changes will be required to understand both short- and long-term effects of MBMTs, as well as gauge how these changes relate to symptom relief when employed in patients with chronic conditions.PROSPERO ID CRD42022315399

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了解炎症介质对心身运动疗法(MBMTs)反应的动力学:对健康受试者研究的系统回顾和荟萃分析
背景炎症的调节已被认为是身心运动疗法(MBMT)的一个潜在的重要方面。运动医学的研究描绘了常规运动后的炎症级联反应;然而,关于MBMT后炎症调节的研究相对较少。目的综合现有文献,研究MBMT干预对健康个体全身炎症介质的短期和长期影响。方法根据系统评价首选报告项目和荟萃分析指南,对炎症介质进行系统评价和荟萃分析。我们寻求在健康个体中进行随机对照试验,将MBMT与测量全身炎症标志物的被动或主动对照进行比较。我们在随机试验中使用了Cochrane偏倚风险工具。Hedges的g和95%置信区间在各研究中进行了计算。结果在已鉴定的3122项研究中,23项符合合成条件。所研究的最常见的MBMT是瑜伽(n=11)、气功(n=4)、太极(n=3)、MBSR(n=3)和舞蹈疗法(n=2)。练习频率(最常见的是每周3次)、干预持续时间(3次短期、单次和20次长期,重复时间大于1周)和疗程长度(最常见为30-60分钟)显示出研究之间的高度异质性。最常见的是前和抗炎蛋白(n=20项研究),其次是免疫细胞(n=5)、脂质介质(n=4)以及体液和补体因子(n=2)。大多数炎症介质没有变化或减少,很少有炎症介质水平升高。荟萃分析表明,长期MBMT后,全身CRP水平显著下降(Hedges g=-0.351;CI=-0.580,-0.123)和TNF-,和IL-6随着类似于传统运动的长期MBMT而降低,MBMT后炎症介质的总体变化轨迹可能更为微妙。未来需要进行仔细控制的研究,包括评估前后变化的精确干预参数,以了解MBMT的短期和长期影响,并衡量这些变化与慢性病患者症状缓解的关系。普罗旺索ID CRD42022315399
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