Jonathan Bennett MS (Primary Author) , Michael Wong PhD (Contributing Author) , Carla Prado (Contributing Author) , Steven Heymsfield MD (Contributing Author) , John Shepherd PhD (Contributing Author)
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Beyond overall obesity, VAT storage is associated with adverse metabolic parameters that increase the risk of heart disease, stroke, and type II diabetes. Computed tomography (CT) and magnetic resonance imaging (MRI) technologies have been used to define thresholds of VAT associated with MetS, however these techniques are of limited availability for clinical risk assessment. Dual energy X-ray absorptiometry (DXA) is accurate compared to VAT measures from CT and MRI, however differences in scanning region and algorithms results in device-specific VAT estimates. We recently generated cross-calibration equations for DXA systems, allowing DXA measures to be compared to CT and MRI and providing more access to VAT assessments for the determination of VAT thresholds as well as the ability to assess presence of “risky” VAT levels in clinical practice. The purpose of this review was to identify published studies defining VAT thresholds to determine characteristics that define the “risky” threshold.
Methods
We identified previously published studies establishing VAT thresholds associated with increased cardiometabolic risk, obtained using CT, MRI, and DXA imaging technologies. We compared characteristics of these studies to determine the factors necessary to identify “risky” VAT thresholds.
Results
We identified 46 studies that derived VAT-specific thresholds associated with MetS in adults, published across populations with diverse sample size, age, and ethnicity. Lower average VAT as well as risk thresholds were found in females. When stratified by age or menopausal status, lower VAT thresholds were primarily observed in lower age or premenopausal categories. Values varied across ethnicities, with level thresholds often lower in Asian populations (70- 136 cm2) compared to Caucasian (85.6-165.9 cm2) and other populations. A universal VAT threshold is not yet feasible, supporting the need for more population-specific thresholds to identify increased MetS risk.
Implications
Excess VAT accumulation above a certain threshold is strongly linked to MetS risk, however the need for age-, sex- and ethnic-specific thresholds in necessary. The development of thresholds based on sex is necessary to reduce the risk of underestimation of “risky” VAT in females. Additionally, these findings suggest that different adipose tissue regions may have differential effects on metabolic disease risk among race/ethnic groups.
期刊介绍:
The Journal is committed to serving ISCD''s mission - the education of heterogenous physician specialties and technologists who are involved in the clinical assessment of skeletal health. The focus of JCD is bone mass measurement, including epidemiology of bone mass, how drugs and diseases alter bone mass, new techniques and quality assurance in bone mass imaging technologies, and bone mass health/economics.
Combining high quality research and review articles with sound, practice-oriented advice, JCD meets the diverse diagnostic and management needs of radiologists, endocrinologists, nephrologists, rheumatologists, gynecologists, family physicians, internists, and technologists whose patients require diagnostic clinical densitometry for therapeutic management.