Death from the Nile: Empirical formula, molar mass, biosynthesis reaction and Gibbs energy of biosynthesis of the West Nile virus

IF 3 4区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES Microbial Risk Analysis Pub Date : 2023-10-17 DOI:10.1016/j.mran.2023.100281

Marko Popovic , Marta Popovic , Gavrilo Šekularac

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Abstract

From July to October, West Nile virus is the leading cause of mosquito born disease in Europe and North America. This paper reports for the first time a chemical and thermodynamic analysis of the West Nile virus particles, genome and proteins, as well as interactions with its host organism. The empirical formula of mature West Nile virus particles was found through the atom counting method. Based on the empirical formula, biosynthesis reactions were formulated, which describe the formation of new virus live matter. Based on the biosynthesis reactions, Gibbs energy of biosynthesis was determined, which represents the physical driving force for the production of viral and host cell components. Gibbs energy of biosynthesis of the West Nile virus was found to be several times more negative than that of its host tissues. Due to the more negative Gibbs energy of biosynthesis, the West Nile virus components are produced much faster than those of its host cells. This allows the virus to hijack the host cell metabolism. Therefore, the virus-host interactions of the West Nile virus were explained through chemical and thermodynamic analysis.

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尼罗河死亡:经验公式、摩尔质量、西尼罗河病毒生物合成反应和吉布斯能

从7月到10月，西尼罗河病毒是欧洲和北美蚊子传播疾病的主要原因。本文首次报道了西尼罗河病毒颗粒、基因组和蛋白质的化学和热力学分析，以及与宿主的相互作用。通过原子计数法，找到了成熟西尼罗河病毒颗粒的经验公式。根据经验公式，制定了生物合成反应，描述了新病毒活物质的形成。基于生物合成反应，确定了生物合成的吉布斯能，它代表了病毒和宿主细胞成分产生的物理驱动力。研究发现，西尼罗河病毒生物合成的吉布斯能是其宿主组织的几倍。由于生物合成的吉布斯能更负，西尼罗河病毒成分的产生速度比宿主细胞快得多。这使得病毒能够劫持宿主细胞的新陈代谢。因此，通过化学和热力学分析解释了西尼罗河病毒与宿主的相互作用。

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来源期刊

Microbial Risk Analysis Medicine-Microbiology (medical)

CiteScore

5.70

自引率

7.10%

发文量

审稿时长

52 days

期刊介绍： The journal Microbial Risk Analysis accepts articles dealing with the study of risk analysis applied to microbial hazards. Manuscripts should at least cover any of the components of risk assessment (risk characterization, exposure assessment, etc.), risk management and/or risk communication in any microbiology field (clinical, environmental, food, veterinary, etc.). This journal also accepts article dealing with predictive microbiology, quantitative microbial ecology, mathematical modeling, risk studies applied to microbial ecology, quantitative microbiology for epidemiological studies, statistical methods applied to microbiology, and laws and regulatory policies aimed at lessening the risk of microbial hazards. Work focusing on risk studies of viruses, parasites, microbial toxins, antimicrobial resistant organisms, genetically modified organisms (GMOs), and recombinant DNA products are also acceptable.