Hematological indices as predictors of intracerebral hematoma expansion detected on serial computed tomography

IF 1.3 Q4 CLINICAL NEUROLOGY Brain Hemorrhages Pub Date : 2023-09-01 DOI:10.1016/j.hest.2023.02.004
K. Suprasanna , H.B. Sridevi , S.R. Ravikiran , Ishank Jain , Varun Holla
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引用次数: 0

Abstract

Objective

Hematoma expansion is associated with unfavourable neurological outcomes in intracranial haemorrhage. We aimed to study association of red blood cell (RBC) indices, platelet indices, and their ratios with hematoma expansion, detected by serial computed tomography (CT).

Methods

Hospital-based observational study of 88 patients with intracerebral hematoma referred for serial CT head with patients grouped as having progression/ no change/ resolution of hematoma. Baseline hematological indices and ratios were analysed.

Results

40 patients (45.5 %) had resolution, 20 patients (22.7 %) had no change and 28 patients (31.8 %) had progression of hematoma. RBC distribution width (RDW) (p value 0.001) and Plateletcrit (p-value 0.009) showed statistically significant difference among the groups. RBC distribution width (RDW) to PC ratio (RPR) showed statistically significant increase (p < 0.001) in patients with progression. Receiver operating characteristic curve with RPR as test variable in predicting progression of hematoma showed cut-off value as 0.0615 (64.3 % sensitivity, 63.3 % specificity). Patients with RPR > 0.0615 had greater chances of hematoma progression {OR 3.1 (95 % CI 1.22 to 7.91); p = 0.0174}

Conclusion

Raised RPR was most significant parameter with higher RDW, lower plateletcrit values in patients with progression of intra-parenchymal hematoma. These readily available indices can aid in prompt prognostication of intracerebral haemorrhage cases.

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血液学指标作为连续计算机断层扫描检测到的脑内血肿扩大的预测指标
目的颅内出血的血肿扩张与不良的神经系统结果有关。我们的目的是研究红细胞(RBC)指数、血小板指数及其比值与连续计算机断层扫描(CT)检测到的血肿扩张的关系。分析了基线血液学指标和比率。结果血肿消退40例(45.5%),无改变20例(22.7%),血肿进展28例(31.8%)。红细胞分布宽度(RDW)(p值0.001)和血小板压积(p值0.009)在各组之间显示出统计学上的显著差异。RBC分布宽度(RDW)与PC比率(RPR)在进展患者中显示出统计学上显著增加(p<0.001)。以RPR作为预测血肿进展的测试变量的受试者操作特征曲线显示截止值为0.0615(敏感性64.3%,特异性63.3%)。RPR患者>;0.0615有更大的血肿进展机会{OR 3.1(95%CI 1.22-7.91);p=0.0174}结论在实质内血肿进展的患者中,RPR升高是RDW较高、红细胞压积值较低的最显著参数。这些现成的指标可以帮助及时预测脑出血病例。
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来源期刊
Brain Hemorrhages
Brain Hemorrhages Medicine-Surgery
CiteScore
2.90
自引率
0.00%
发文量
52
审稿时长
22 days
期刊最新文献
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