An Investigation of the Effects of B7-H4 Gene rs10754339 and miR-125a Gene rs12976445 on Cancer Susceptibility

IF 3 3区医学 Q2 ENVIRONMENTAL SCIENCES Biomedical and Environmental Sciences Pub Date : 2023-09-01 DOI:10.3967/bes2023.074

Yu Chen JIN , Li Juan DONG , Qin Yue YANG , Wei Ning XIONG , Wei Yi WANG , Xian Hong FENG , Wei YU , Wei HUANG , Bi Feng CHEN

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Abstract

Objective

To investigate the effects of the B7-H4 gene rs10754339 and miR-125a gene rs12976445 on cancer susceptibility through a case-control study and meta-analysis.

Methods

A total of 1,490 cancer patients (lung/gastric/liver/: 550/460/480) and 800 controls were recruited in this case-control study. The meta-analysis was performed by pooling the data from previous related studies and the present study.

Results

The results of this study showed that in the Hubei Han Chinese population, the rs10754339 gene was significantly associated with the risk of lung and gastric cancer but not liver cancer, and the rs12976445 gene was significantly associated with the risk of lung cancer but not liver or gastric cancer. The meta-analysis results indicated that rs10754339 and rs12976445 contributed to cancer susceptibility in the Chinese population and also revealed a significant association between rs10754339 and breast cancer risk, as well as between rs12976445 and lung cancer risk.

Conclusion

The B7-H4 gene rs10754339 and miR-125a gene rs12976445 may be the potential genetic markers for cancer susceptibility in the Chinese population, which should be validated in future studies with larger sample sizes in other ethnic populations.

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B7-H4基因rs10754339和miR-125a基因rs12976445对肿瘤易感性影响的研究

目的通过病例对照和荟萃分析研究B7-H4基因rs10754339和miR-125a基因rs12976445对癌症易感性的影响。方法对1490例癌症患者（肺/胃/肝/：550/460/480）和800例对照者进行病例对照研究。荟萃分析是通过汇集先前相关研究和本研究的数据进行的。结果在湖北汉族人群中，rs10754339基因与肺癌和胃癌癌症风险显著相关，但与癌症风险无关，rs12976445基因与肺癌或胃癌风险显著相关。荟萃分析结果表明，rs10754339和rs12976445对中国人群癌症易感性有贡献，并揭示了rs10754338与癌症风险以及rs1297645与癌症风险之间的显著关联。结论B7-H4基因rs10754339和miR-125a基因rs12976445可能是中国人群癌症易感性的潜在遗传标志物，这一点应在未来的研究中得到验证，在其他民族人群中进行更大的样本量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedical and Environmental Sciences 环境科学-公共卫生、环境卫生与职业卫生

CiteScore

2.60

自引率

8.60%

发文量

2170

审稿时长

1.0 months

期刊介绍： Biomedical and Environmental Sciences (BES) is a peer-reviewed journal jointly established by the Chinese Center for Disease Control and Prevention (China CDC) and the Coulston International Corporation (CIC), USA in 1988, and is published monthly by Elsevier. It is indexed by SCI, PubMed, and CA. Topics covered by BES include infectious disease prevention, chronic and non-communicable disease prevention, disease control based on preventive medicine, and public health theories. It also focuses on the health impacts of environmental factors in people''s daily lives and work, including air quality, occupational hazards, and radiation hazards. Article types considered for publication include original articles, letters to the editor, reviews, research highlights, and policy forum.