Biomedical and Environmental Sciences最新文献

英文中文

Academic Conference on Vaccines Preventing Respiratory Infections Successfully Held in Beijing 预防呼吸道感染疫苗学术会议在北京成功召开。

3区医学 Q2 ENVIRONMENTAL SCIENCES

Biomedical and Environmental Sciences

Pub Date : 2023-11-01 DOI: 10.3967/bes2023.145

Yuan Yuan XU

引用次数: 0

Carbon Chain Length Determines Inhibitory Potency of Perfluoroalkyl Sulfonic Acids on Human Placental 3β-Hydroxysteroid Dehydrogenase 1: Screening, Structure-Activity Relationship, and In Silico Analysis 碳链长度决定全氟烷基磺酸对人类胎盘 3β- 羟类固醇脱氢酶 1 的抑制效力：筛选、结构-活性关系和硅学分析。

3区医学 Q2 ENVIRONMENTAL SCIENCES

Biomedical and Environmental Sciences

Pub Date : 2023-11-01 DOI: 10.3967/bes2023.132

Lu Ming TANG , Bai Ping MAO , Bing Ru ZHANG , Jing Jing LI , Yun Bing TANG , Hui Tao LI , Ren Shan GE

Objective

This study aimed to compare 9 perfluoroalkyl sulfonic acids (PFSA) with carbon chain lengths (C4-C12) to inhibit human placental 3β-hydroxysteroid dehydrogenase 1 (3β-HSD1), aromatase, and rat 3β-HSD4 activities.

Methods

Human and rat placental 3β-HSDs activities were determined by converting pregnenolone to progesterone and progesterone secretion in JEG-3 cells was determined using HPLC/MS–MS, and human aromatase activity was determined by radioimmunoassay.

Results

PFSA inhibited human 3β-HSD1 structure-dependently in the order: perfluorooctanesulfonic acid (PFOS, half-maximum inhibitory concentration, IC₅₀: 9.03 ± 4.83 µmol/L) > perfluorodecanesulfonic acid (PFDS, 42.52 ± 8.99 µmol/L) > perfluoroheptanesulfonic acid (PFHpS, 112.6 ± 29.39 µmol/L) > perfluorobutanesulfonic acid (PFBS) = perfluoropentanesulfonic acid (PFPS) = perfluorohexanesulfonic acid (PFHxS) = perfluorododecanesulfonic acid (PFDoS) (ineffective at 100 µmol/L). 6:2FTS (1H, 1H, 2H, 2H-perfluorooctanesulfonic acid) and 8:2FTS (1H, 1H, 2H, 2H-perfluorodecanesulfonic acid) did not inhibit human 3β-HSD1. PFOS and PFHpS are mixed inhibitors, whereas PFDS is a competitive inhibitor. Moreover, 1–10 µmol/L PFOS and PFDS significantly reduced progesterone biosynthesis in JEG-3 cells. Docking analysis revealed that PFSA binds to the steroid-binding site of human 3β-HSD1 in a carbon chain length-dependent manner. All 100 µmol/L PFSA solutions did not affect rat 3β-HSD4 and human placental aromatase activity.

Conclusions

Carbon chain length determines inhibitory potency of PFSA on human placental 3β-HSD1 in a V-shaped transition at PFOS (C8), with inhibitory potency of PFOS > PFDS > PFHpS > PFBS = PFPS = PFHxS = PFDoS = 6:2FTS = 8:2FTS.

研究目的本研究旨在比较碳链长度为 C4-C12 的 9 种全氟烷基磺酸 (PFSA) 对人胎盘 3β- 羟类固醇脱氢酶 1 (3β-HSD1)、芳香化酶和大鼠 3β-HSD4 活性的抑制作用。方法：通过将孕烯醇酮转化为孕酮测定人和大鼠胎盘 3β-HSDs 的活性，使用 HPLC/MS-MS 测定 JEG-3 细胞中孕酮的分泌量，使用放射免疫测定人芳香化酶的活性：结果：全氟辛烷磺酸对人 3β-HSD1 结构的抑制依次为：全氟辛烷磺酸（PFOS，半最大抑制浓度，IC 50：9.03 ± 4.83 μmol/L） > 全氟癸烷磺酸（PFDS，42.52 ± 8.99 μmol/L) > 全氟庚烷磺酸 (PFHpS, 112.6 ± 29.39 μmol/L) > 全氟丁烷磺酸 (PFBS) = 全氟戊烷磺酸 (PFPS) = 全氟己烷磺酸 (PFHxS) = 全氟十二烷磺酸 (PFDoS) (100 μmol/L 时无效)。6:2FTS（1H、1H、2H、2H-全氟辛烷磺酸）和 8:2FTS（1H、1H、2H、2H-全氟癸烷磺酸）对人类 3β-HSD1 没有抑制作用。PFOS 和 PFHpS 是混合抑制剂，而 PFDS 是竞争抑制剂。此外，1-10 μmol/L PFOS 和 PFDS 能显著降低 JEG-3 细胞中孕酮的生物合成。对接分析表明，全氟辛烷磺酸与人 3β-HSD1 的类固醇结合位点结合的方式与碳链长度有关。所有 100 μmol/L 的 PFSA 溶液都不会影响大鼠 3β-HSD4 和人胎盘芳香化酶的活性：碳链长度决定了 PFSA 对人胎盘 3β-HSD1 的抑制效力，在 PFOS（C8）处呈 V 型转变，抑制效力为 PFOS > PFDS > PFHpS > PFBS = PFPS = PFHxS = PFDoS = 6:2FTS = 8:2FTS。

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引用次数: 0

The Psychosomatic Traits of “People with the Five Elements in Traditional Chinese Medicine”: A Qualitative Study 中医五行人 "的心身特质：定性研究。

3区医学 Q2 ENVIRONMENTAL SCIENCES

Biomedical and Environmental Sciences

Pub Date : 2023-11-01 DOI: 10.3967/bes2023.136

Jia Jia LI , Xin Yu YANG , Hong Jun ZHANG , Dong Qing YIN , Jin Tao ZHANG , Jing Wen CUI , Jing Dong HAN , Yan MA , Hong Xiao JIA

Objective

To identify the representative attributes of the five elements of a person with a qualitative methodology and provide the basis for the clinical diagnosis and treatment of “people with the five elements in traditional Chinese medicine (TCM).”

Methods

Data collected from the literature review, two sessions of brainstorming of experts with related experience in “people with the five elements in TCM” from October 2020 to December 2020, and six rounds of in-depth interviews with 30 participants who had various attributes of the five elements from March 2021 to October 2021 were analyzed. Triangulation was used in this study, and theming and synthesizing were used to analyze the data.

Results

A total of 31 experts and 30 interviewees participated in this study. The median age of the experts and interviewees were 48.0 and 38.5 years, respectively; 51.66% and 54.8% of experts and interviewees, respectively, were men. The descriptors of facial diagrams of “people with the five elements in TCM” were complexion, shape, distribution state of facial bones, convergence trend of facial muscles, and facial expression. A theoretical model of “people with the five elements in TCM” was shaped based on these findings.

Conclusions

The study suggests a possibility for bridging the gap between personality and bodily state, identifying an avenue for personality research from the perspective of TCM.

目的用定性方法识别人的五行代表属性，为 "中医五行人群 "的临床诊治提供依据：通过文献综述、2020年10月至2020年12月两次 "中医五行人群 "相关经验专家的头脑风暴、2021年3月至2021年10月对30名具有不同五行属性的参与者进行的6轮深度访谈，对收集到的数据进行分析。本研究采用了三角分析法，并对数据进行了主题分析和综合分析：共有 31 位专家和 30 位受访者参与了本研究。专家和受访者的年龄中位数分别为 48.0 岁和 38.5 岁；男性分别占专家和受访者的 51.66%和 54.8%。中医五行人 "面相图的描述指标为肤色、面形、面骨分布状态、面肌收敛趋势和面部表情。在此基础上形成了 "中医五行人 "的理论模型：结论：本研究为缩小人格与身体状态之间的差距提供了一种可能，为从中医角度研究人格提供了一条途径。

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引用次数: 0

Association between Temperature Changes and Cardiovascular Mortality Risk in A High-latitude City in Northeast China 中国东北高纬度城市气温变化与心血管疾病死亡风险之间的关系

3区医学 Q2 ENVIRONMENTAL SCIENCES

Biomedical and Environmental Sciences

Pub Date : 2023-11-01 DOI: 10.3967/bes2023.140

He Ping LI , Yu Xia MA , Peng Peng QIN , Wan Ci WANG , Zong Rui LIU , Yu Han ZHAO , Li Jie YANG

引用次数: 0

National Hypertension Day: Healthy Living, Ideal Blood Pressure 全国高血压日：健康生活，理想血压。

3区医学 Q2 ENVIRONMENTAL SCIENCES

Biomedical and Environmental Sciences

Pub Date : 2023-11-01 DOI: 10.3967/bes2023.146

Yuan Yuan XU

引用次数: 0

DJ1 Ameliorates AD-like Pathology in the Hippocampus of APP/PS1 Mice DJ1可改善APP/PS1小鼠海马中的AD样病理变化

3区医学 Q2 ENVIRONMENTAL SCIENCES

Biomedical and Environmental Sciences

Pub Date : 2023-11-01 DOI: 10.3967/bes2023.133

Yang Yang PENG , Meng Xin LI , Wen Jie LI , Yuan XUE , Yu Fan MIAO , Yu Lin WANG , Xiao Chen FAN , Lu Lu TANG , SONG Han Lu , Qian ZHANG , Xing LI

Objective

To explore whether the protein Deglycase protein 1 (DJ1) can ameliorate Alzheimer's disease (AD)-like pathology in Amyloid Precursor Protein/Presenilin 1 (APP/PS1) double transgenic mice and its possible mechanism to provide a theoretical basis for exploring the pathogenesis of AD.

Methods

Adeno-associated viral vectors (AAV) of DJ1-overexpression or DJ1-knockdown were injected into the hippocampus of 7-month-old APP/PS1 mice to construct models of overexpression or knockdown. Mice were divided into the AD model control group (MC), AAV vector control group (NC), DJ1-overexpression group (DJ1+), and DJ1-knockdown group (DJ1^–). After 21 days, the Morris water maze test, immunohistochemistry, immunofluorescence, and western blotting were used to evaluate the effects of DJ1 on mice.

Results

DJ1+ overexpression decreased the latency and increased the number of platform traversals in the water maze test. DJ1^– cells were cured and atrophied, and the intercellular structure was relaxed; the number of age spots and the expression of AD-related proteins were significantly increased. DJ1⁺ increased the protein expression of Nuclear factor erythroid 2-related factor 2 (NRF2), heme oxygenase-1 (HO-1), light chain 3 (LC3), phosphorylated AMPK (p-AMPK), and B cell lymphoma-2 (BCL-2), as well as the antioxidant levels of total superoxide dismutase (T-SOD), total antioxidant capacity (T-AOC), and Glutathione peroxidase (GSH-PX), while decreasing the levels of Kelch-like hydrates-associated protein 1 (Keap1), mammalian target of rapamycin (mTOR), p62/sequestosome1 (p62/SQSTM1), Caspase3, and malondialdehyde (MDA).

Conclusions

DJ1-overexpression can ameliorate learning, memory, and AD-like pathology in APP/PS1 mice, which may be related to the activation of the NRF2/HO-1 and AMPK/mTOR pathways by DJ1.

目的探讨蛋白Deglycase protein 1（DJ1）能否改善淀粉样前体蛋白/早老素1（APP/PS1）双转基因小鼠的阿尔茨海默病（AD）样病理变化及其可能机制，为探索AD的发病机制提供理论依据：方法：在7月龄APP/PS1小鼠海马中注射DJ1-overexpression或DJ1-knockdown腺相关病毒载体（AAV），构建DJ1-overexpression或DJ1-knockdown模型。小鼠被分为AD模型对照组（MC）、AAV载体对照组（NC）、DJ1-过表达组（DJ1 +）和DJ1-敲除组（DJ1 -）。21天后，采用莫里斯水迷宫试验、免疫组化、免疫荧光和免疫印迹法评估DJ1对小鼠的影响：结果：DJ1 +过表达降低了水迷宫试验的潜伏期，增加了平台穿越次数。DJ1 -细胞固化萎缩，细胞间结构松弛；老年斑数量和AD相关蛋白表达量显著增加。DJ1 +能增加核因子红细胞2相关因子2（NRF2）、血红素加氧酶-1（HO-1）、轻链3（LC3）、磷酸化AMPK（p-AMPK）和B细胞淋巴瘤-2（BCL-2）的蛋白表达，以及总超氧化物歧化酶（T-SOD）的抗氧化水平、总超氧化物歧化酶（T-SOD）、总抗氧化能力（T-AOC）和谷胱甘肽过氧化物酶（GSH-PX）的抗氧化水平，同时降低凯尔奇样水合物相关蛋白 1（Keap1）、哺乳动物雷帕霉素靶标（mTOR）、p62/序列体1（p62/SQSTM1）、Caspase3 和丙二醛（MDA）的水平。结论DJ1外表达能改善APP/PS1小鼠的学习、记忆和AD样病理，这可能与DJ1激活了NRF2/HO-1和AMPK/mTOR通路有关。

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引用次数: 0

World Diabetes Day: Global Collaboration against Diabetes Challenges, Building a Health Defense Line 世界糖尿病日：全球合作应对糖尿病挑战，构筑健康防线。

3区医学 Q2 ENVIRONMENTAL SCIENCES

Biomedical and Environmental Sciences

Pub Date : 2023-11-01 DOI: 10.3967/bes2023.147

Yuan Yuan XU

引用次数: 0

Decontamination Efficacy of Disinfection and Doffing of Medical Protective Clothing: A Combined Mannequin and Personnel Study 医用防护服消毒和脱下的去污效果：人体模型和人员联合研究。

3区医学 Q2 ENVIRONMENTAL SCIENCES

Biomedical and Environmental Sciences

Pub Date : 2023-11-01 DOI: 10.3967/bes2023.142

Zhong Yi XIE , Long Xi LU , Ye LI , Ling Feng FAN , Fan Fan YANG , Ye LU

引用次数: 0

The Value of Prealbumin and its Combination with NT-proBNP for Predicting in-hospital Mortality in Patients with Heart Failure: Real-World Research Based on Propensity Score Matching 前白蛋白及其与 NT-proBNP 联用对预测心衰患者院内死亡率的价值：基于倾向得分匹配的真实世界研究

3区医学 Q2 ENVIRONMENTAL SCIENCES

Biomedical and Environmental Sciences

Pub Date : 2023-11-01 DOI: 10.3967/bes2023.139

Bing LIU, Jia Yi XIE

引用次数: 0

The Effect of Intense Pulsed Light Treatment for Chronic Hordeolum 强脉冲光治疗对慢性角皮病的影响

3区医学 Q2 ENVIRONMENTAL SCIENCES

Biomedical and Environmental Sciences

Pub Date : 2023-11-01 DOI: 10.3967/bes2023.131

Ke YANG , Ya WEN , Lei ZHU, Jia Yu BAO, Shang LI, Ying Hui WANG, Jun FENG, Lei TIAN, Ying JIE

Objective

To evaluate the effect of intense pulsed light (IPL) in the treatment of chronic hordeolum.

Methods

Patients with chronic hordeolum who underwent IPL treatment were enrolled in this study. According to the severity of hordeolum, the patients were treated with IPL 3 to 5 times. Patients’ satisfaction and visual analog scale scores for ocular discomfort symptoms before and after treatment were collected. The number, congestion, long diameter, short diameter and area of nodules were also recorded and measured. Finally, eyelid margin signs, meibum quality, meibomian gland expressibility, meibomian gland dropout, tear meniscus height, and corneal fluorescein staining were scored.

Results

20 patients were enrolled in this study. The eyelid margins were congestive and swollen, with blunt rounding or irregularity. The meibum was cloudy or toothpaste-like. The meibomian gland expressibility, meibomian gland dropout and tear meniscus height were reduced. The cornea showed scattered fluorescein staining. After treatment, score of visual analog scale, congestion and size of nodules were significantly reduced. Eyelid margin signs, meibum quality, meibomian gland expressibility, tear meniscus height and corneal fluorescein staining scores were improved. Meibomian gland dropout had no significant change. No side effects occurred during treatment.

Conclusions

IPL is beneficial for the treatment of chronic hordeolum.

目的：评估强脉冲光（IPL）治疗慢性角化病的效果：评估强脉冲光（IPL）治疗慢性角化病的效果：研究对象为接受强脉冲光治疗的慢性角化病患者。根据角化病的严重程度，患者接受了 3 至 5 次强脉冲光治疗。收集了治疗前后患者对眼部不适症状的满意度和视觉模拟量表评分。此外，还记录并测量了结节的数量、充血程度、长径、短径和面积。最后，对眼睑边缘体征、睑板腺质量、睑板腺表达能力、睑板腺脱落、泪液半月板高度和角膜荧光素染色进行评分。眼睑边缘充血肿胀，钝圆或不规则。睑板腺混浊或呈牙膏样。睑板腺表达率、睑板腺脱落率和泪液半月板高度降低。角膜出现散在荧光素染色。治疗后，视觉模拟量表的评分、结节的充血和大小均明显减少。眼睑边缘体征、睑板腺质量、睑板腺表达能力、泪液半月板高度和角膜荧光素染色评分均有所改善。睑板腺脱落无明显变化。治疗期间未出现副作用：结论：强脉冲光治疗慢性角膜病是有益的。

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