O. I. Vernaya, A. S. Shumilkin, D. L. Karlova, A. S. Shevchenko, A. A. Makeeva, A. V. Shabatin, A. M. Semenov, T. I. Shabatina, M. Ya. Melnikov
{"title":"Cryoformation and Properties of Dioxidine/Gelatin Systems","authors":"O. I. Vernaya, A. S. Shumilkin, D. L. Karlova, A. S. Shevchenko, A. A. Makeeva, A. V. Shabatin, A. M. Semenov, T. I. Shabatina, M. Ya. Melnikov","doi":"10.3103/S0027131422070124","DOIUrl":null,"url":null,"abstract":"<p>Cryoforming of gelatin systems with the antibacterial drug dioxidine is carried out. The study considers the effect of systems’ synthesis conditions (gelatin concentration in the precursor solution) on their structural characteristics, antibacterial activity, and drug release time. The composition and structure of the dioxidine/gelatin and dioxidine/hydrolyzed collagen systems are characterized by SEM, IR, and UV spectroscopy. The disk diffusion method is used to determine the antibacterial activity of the obtained systems against <i>E. coli</i> and <i>S. aureus</i>.</p>","PeriodicalId":709,"journal":{"name":"Moscow University Chemistry Bulletin","volume":"77 1","pages":"S7 - S12"},"PeriodicalIF":0.7000,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Moscow University Chemistry Bulletin","FirstCategoryId":"1085","ListUrlMain":"https://link.springer.com/article/10.3103/S0027131422070124","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Cryoforming of gelatin systems with the antibacterial drug dioxidine is carried out. The study considers the effect of systems’ synthesis conditions (gelatin concentration in the precursor solution) on their structural characteristics, antibacterial activity, and drug release time. The composition and structure of the dioxidine/gelatin and dioxidine/hydrolyzed collagen systems are characterized by SEM, IR, and UV spectroscopy. The disk diffusion method is used to determine the antibacterial activity of the obtained systems against E. coli and S. aureus.
期刊介绍:
Moscow University Chemistry Bulletin is a journal that publishes review articles, original research articles, and short communications on various areas of basic and applied research in chemistry, including medical chemistry and pharmacology.