Efficacy of Felpreva®, a new spot-on formulation containing tigolaner, emodepside and praziquantel, applied as a single application to cats artificially infested with ear mites (Otodectes cynotis)

Katrin Blazejak , Alta Viljoen , Reinier Zwiegers , Roland Klopper , Hannah Ringeisen , Gabriele Petry , David R. Young , Douglas Shane , Jennifer Spruill , Ronald K. Tessman , Terry Settje , Tanja N. Knoppe , Norbert Mencke
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引用次数: 2

Abstract

The efficacy of Felpreva® (Vetoquinol), a new spot-on application containing the novel acaricide and insecticide tigolaner in combination with emodepside and praziquantel, was evaluated in cats artificially infested with ear mites (Otodectes cynotis). A total of three pivotal dose confirmation studies were conducted, two of them designed as non-interference studies. Cats were artificially infested with O. cynotis mites and randomly allocated into groups of 8 cats based on pre-treatment mite counts. Cats were treated once on Day 0, either with Felpreva® (14.5 ​mg/kg tigolaner, 3 ​mg/kg emodepside and 12 ​mg/kg praziquantel) or with placebo. Studies with a non-interference design included two additional groups of cats, treated with Profender® spot-on solution (Vetoquinol) (3 ​mg/kg emodepside and 12 ​mg/kg praziquantel) and tigolaner as a mono product (14.5 ​mg/kg tigolaner). Efficacy was evaluated on Day 28/Day 30 based on total live mite counts after ear flushing. Efficacy was claimed when: (i) at least six control cats per group were adequately infested with mites; (ii) calculated efficacy was ≥ 90% based on geometric mean mite counts; and (iii) the difference in mite counts between Felpreva®-treated cats and control cats was statistically significant (P ​≤ ​0.05). In two of the three studies, Felpreva®-treated cats were mite-free (100% efficacy) on Day 28/Day 30 and almost full efficacy (99.6%) was seen in the third study. The difference in mite counts between Felpreva®-treated cats and control cats was significant (P ​< ​0.0001) in all three studies. All control cats were adequately infested in all three studies. The efficacy of Felpreva® against ear mite (Otodectes cynotis) infection in cats was confirmed.

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Felpreva®是一种新的含有替戈拉纳、依莫地肽和吡喹酮的配方,单次应用于人工感染耳螨的猫(Otodectes cynotis)的疗效
Felpreva®(Vetoquinol)是一种新的应用点,含有新型杀螨剂和杀虫剂替戈拉纳,与依莫地肽和吡喹酮联合使用,对人工感染耳螨(Otodectes cynotis)的猫的疗效进行了评估。共进行了三项关键剂量确认研究,其中两项被设计为不干扰研究。猫被人工感染O.cynotis螨,并根据预处理螨数随机分为8只猫。猫在第0天接受一次Felpreva®(14.5​mg/kg替戈拉纳,3​毫克/千克大鼠苷和12​mg/kg吡喹酮)或与安慰剂。非干扰设计的研究包括另外两组猫,用Profender®现场溶液(Vetoquinol)治疗(3​毫克/千克大鼠苷和12​mg/kg吡喹酮)和替戈拉纳作为单一产品(14.5​mg/kg替戈拉纳)。在第28天/30天,基于洗耳后的总活螨计数来评估疗效。当:(i)每组至少有六只对照猫被螨虫充分感染时,就声称有疗效;(ii)基于几何平均螨数计算的疗效≥90%;和(iii)Felpreva®治疗猫和对照猫的螨数差异具有统计学意义(P​≤​0.05)。在三项研究中的两项研究中,Felpreva®治疗的猫在第28天/30天无螨(100%有效),第三项研究几乎完全有效(99.6%)。Felpreva®治疗猫和对照猫的螨数差异显著(P​<;​0.0001)。在所有三项研究中,所有对照猫都受到了充分的感染。Felpreva®对猫耳螨(Otodectes cynotis)感染的疗效已得到证实。
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