Sex-biased and sex hormone-dependent regulation of apolipoprotein A1

IF 2.5 Q2 PHYSIOLOGY Current Opinion in Physiology Pub Date : 2023-06-01 DOI:10.1016/j.cophys.2023.100654

Anja Angelov , Paul J Connelly , Christian Delles , Georgios Kararigas

{"title":"Sex-biased and sex hormone-dependent regulation of apolipoprotein A1","authors":"Anja Angelov , Paul J Connelly , Christian Delles , Georgios Kararigas","doi":"10.1016/j.cophys.2023.100654","DOIUrl":null,"url":null,"abstract":"<div><p><span><span>Pronounced sex differences in the development and outcome of cardiovascular diseases (CVD) exist. Apolipoprotein A1 (APOA1), the basic </span>structural protein of high-density lipoprotein (HDL), is involved in key metabolic processes. However, its role in the pathogenesis of CVD is incompletely understood. The effects of biological sex on factors influencing the APOA1-lipid balance and the underlying mechanisms are also poorly understood. Here, we summarize evidence supporting sex-biased and sex hormone-dependent regulation of APOA1. In particular, we discuss sex-biased </span><em>APOA1</em> genetic variation, sex differences in APOA1 regulation and cardiovascular physiology, and sex hormone-dependent regulation of APOA1 in cis- and transgender individuals. We put forward that studying the effects of biological sex will contribute to a better understanding of the role of APOA1 in cardiovascular physiology and its sex-biased association with CVD. Importantly, in situations of sex hormone therapy or inhibition, more sex-stratified data are required to inform clinical management of APOA1-related cardiovascular risk in a sex-dependent manner.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"33 ","pages":"Article 100654"},"PeriodicalIF":2.5000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Physiology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S246886732300024X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHYSIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Pronounced sex differences in the development and outcome of cardiovascular diseases (CVD) exist. Apolipoprotein A1 (APOA1), the basic structural protein of high-density lipoprotein (HDL), is involved in key metabolic processes. However, its role in the pathogenesis of CVD is incompletely understood. The effects of biological sex on factors influencing the APOA1-lipid balance and the underlying mechanisms are also poorly understood. Here, we summarize evidence supporting sex-biased and sex hormone-dependent regulation of APOA1. In particular, we discuss sex-biased APOA1 genetic variation, sex differences in APOA1 regulation and cardiovascular physiology, and sex hormone-dependent regulation of APOA1 in cis- and transgender individuals. We put forward that studying the effects of biological sex will contribute to a better understanding of the role of APOA1 in cardiovascular physiology and its sex-biased association with CVD. Importantly, in situations of sex hormone therapy or inhibition, more sex-stratified data are required to inform clinical management of APOA1-related cardiovascular risk in a sex-dependent manner.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

载脂蛋白A1的性别偏向性和性激素依赖性调控

心血管疾病（CVD）的发展和结果存在明显的性别差异。载脂蛋白A1（APOA1）是高密度脂蛋白（HDL）的基础结构蛋白，参与关键的代谢过程。然而，它在心血管疾病发病机制中的作用尚不完全清楚。生物学性别对影响APOA1脂质平衡的因素的影响及其潜在机制也知之甚少。在此，我们总结了支持APOA1的性别偏见和性激素依赖性调节的证据。特别是，我们讨论了性别偏见的APOA1基因变异、APOA1调节和心血管生理学的性别差异，以及顺式和转基因个体中APOA1的性激素依赖性调节。我们提出，研究生物性别的影响将有助于更好地理解APOA1在心血管生理学中的作用及其与CVD的性别偏见关系。重要的是，在性激素治疗或抑制的情况下，需要更多的性别分层数据来以性别依赖的方式告知APOA1相关心血管风险的临床管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊