Surface modifications of nanocellulose for drug delivery applications; a critical review

IF 4.7 3区 工程技术 Q2 ENGINEERING, BIOMEDICAL Current Opinion in Biomedical Engineering Pub Date : 2023-06-08 DOI:10.1016/j.cobme.2023.100475
Muhammad Mujtaba , Arvind Negi , Alistair W.T. King , Mina Zare , Johana Kuncova-Kallio
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Abstract

With the development of novel drugs and the discovery of new targets, there is an increased need for novel drug carriers. Nanocellulose has great potential to become a novel drug carrier thanks to its biocompatibility, low toxicity, tunable chemical structure, and sustainability. There are many types of nanocelluloses based on their physical properties (particle size, shape, surface charge), chemical properties (surface functional groups), form (lyophilized, hydrogel, aerogel, membrane) and source (bacterial, animal, plant) and that also largely influences drug release patterns, but also toxicity profile. To our knowledge, so far, no nanocellulose materials have been accepted as ingredients for pharmaceutical formulations. Some types of nanocellulose have however been accepted for use in medical devices, which is also a tightly regulated area. This review focuses on the modification of nanocellulose to enhance its capability as a drug delivery agent and pinpoints the pitfalls for the registration of such novel sustainable material.

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用于药物递送应用的纳米纤维素的表面改性;批判性评论
随着新药的开发和新靶点的发现,对新型药物载体的需求越来越大。纳米纤维素具有生物相容性、低毒性、化学结构可调和可持续性等优点,具有成为新型药物载体的巨大潜力。纳米纤维素的物理性质(粒径、形状、表面电荷)、化学性质(表面官能团)、形式(冻干、水凝胶、气凝胶、膜)和来源(细菌、动物、植物)有多种类型,这也在很大程度上影响药物释放模式,但也影响毒性。据我们所知,到目前为止,还没有任何纳米纤维素材料被接受作为药物配方的成分。然而,一些类型的纳米纤维素已被接受用于医疗器械,这也是一个严格监管的领域。这篇综述的重点是对纳米纤维素进行修饰,以增强其作为药物递送剂的能力,并指出了这种新型可持续材料注册的陷阱。
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Current Opinion in Biomedical Engineering
Current Opinion in Biomedical Engineering Medicine-Medicine (miscellaneous)
CiteScore
8.60
自引率
2.60%
发文量
59
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