{"title":"Exercise and calcium in the heart","authors":"Ole J Kemi","doi":"10.1016/j.cophys.2023.100644","DOIUrl":null,"url":null,"abstract":"<div><p>Cardiomyocyte Ca<sup>2+</sup> dictates cardiac contraction via excitation–contraction coupling (ECC) and excitation–transcription coupling. Adaptation to these processes also majorly contributes to enhanced contractile function and capacity following exercise training. Cytoplasmic Ca<sup>2+</sup> release controls sarcomeric contraction, with important modulation by the voltage-sensitive plasma membrane <span>L</span>-type Ca<sup>2+</sup> channel and the Ryanodine receptor, as well as the sarcoplasmic reticulum Ca<sup>2+</sup> ATPase. Exercise training increases and enhances these ECC subprocesses, in a manner that increases and enhances cardiac contraction. Also, adaptation to exercise training further includes myofilament Ca<sup>2+</sup> sensitization. Then, there are several aspects linked to postexercise training cardiomyocyte Ca<sup>2+</sup> handling that remains speculative and inconclusive, but could if proven true to be of special importance. This includes Ca<sup>2+</sup>-linked muscle-specific gene transcription to alter cell architecture and size, and it includes the scenario whereby Ca<sup>2+</sup> cycling and adaptations may alter arrhythmogenicity. These aspects of cardiac Ca<sup>2+</sup> adaptations to exercise training are discussed in this review article.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"32 ","pages":"Article 100644"},"PeriodicalIF":2.5000,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Physiology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468867323000147","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Cardiomyocyte Ca2+ dictates cardiac contraction via excitation–contraction coupling (ECC) and excitation–transcription coupling. Adaptation to these processes also majorly contributes to enhanced contractile function and capacity following exercise training. Cytoplasmic Ca2+ release controls sarcomeric contraction, with important modulation by the voltage-sensitive plasma membrane L-type Ca2+ channel and the Ryanodine receptor, as well as the sarcoplasmic reticulum Ca2+ ATPase. Exercise training increases and enhances these ECC subprocesses, in a manner that increases and enhances cardiac contraction. Also, adaptation to exercise training further includes myofilament Ca2+ sensitization. Then, there are several aspects linked to postexercise training cardiomyocyte Ca2+ handling that remains speculative and inconclusive, but could if proven true to be of special importance. This includes Ca2+-linked muscle-specific gene transcription to alter cell architecture and size, and it includes the scenario whereby Ca2+ cycling and adaptations may alter arrhythmogenicity. These aspects of cardiac Ca2+ adaptations to exercise training are discussed in this review article.