Exercise and calcium in the heart

IF 2.5 Q2 PHYSIOLOGY Current Opinion in Physiology Pub Date : 2023-04-01 DOI:10.1016/j.cophys.2023.100644
Ole J Kemi
{"title":"Exercise and calcium in the heart","authors":"Ole J Kemi","doi":"10.1016/j.cophys.2023.100644","DOIUrl":null,"url":null,"abstract":"<div><p>Cardiomyocyte Ca<sup>2+</sup> dictates cardiac contraction via excitation–contraction coupling (ECC) and excitation–transcription coupling. Adaptation to these processes also majorly contributes to enhanced contractile function and capacity following exercise training. Cytoplasmic Ca<sup>2+</sup> release controls sarcomeric contraction, with important modulation by the voltage-sensitive plasma membrane <span>L</span>-type Ca<sup>2+</sup> channel and the Ryanodine receptor, as well as the sarcoplasmic reticulum Ca<sup>2+</sup> ATPase. Exercise training increases and enhances these ECC subprocesses, in a manner that increases and enhances cardiac contraction. Also, adaptation to exercise training further includes myofilament Ca<sup>2+</sup> sensitization. Then, there are several aspects linked to postexercise training cardiomyocyte Ca<sup>2+</sup> handling that remains speculative and inconclusive, but could if proven true to be of special importance. This includes Ca<sup>2+</sup>-linked muscle-specific gene transcription to alter cell architecture and size, and it includes the scenario whereby Ca<sup>2+</sup> cycling and adaptations may alter arrhythmogenicity. These aspects of cardiac Ca<sup>2+</sup> adaptations to exercise training are discussed in this review article.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"32 ","pages":"Article 100644"},"PeriodicalIF":2.5000,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Physiology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468867323000147","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Cardiomyocyte Ca2+ dictates cardiac contraction via excitation–contraction coupling (ECC) and excitation–transcription coupling. Adaptation to these processes also majorly contributes to enhanced contractile function and capacity following exercise training. Cytoplasmic Ca2+ release controls sarcomeric contraction, with important modulation by the voltage-sensitive plasma membrane L-type Ca2+ channel and the Ryanodine receptor, as well as the sarcoplasmic reticulum Ca2+ ATPase. Exercise training increases and enhances these ECC subprocesses, in a manner that increases and enhances cardiac contraction. Also, adaptation to exercise training further includes myofilament Ca2+ sensitization. Then, there are several aspects linked to postexercise training cardiomyocyte Ca2+ handling that remains speculative and inconclusive, but could if proven true to be of special importance. This includes Ca2+-linked muscle-specific gene transcription to alter cell architecture and size, and it includes the scenario whereby Ca2+ cycling and adaptations may alter arrhythmogenicity. These aspects of cardiac Ca2+ adaptations to exercise training are discussed in this review article.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
运动与心脏中的钙
心肌细胞Ca2+通过兴奋-收缩偶联(ECC)和兴奋-转录偶联控制心脏收缩。适应这些过程也主要有助于增强运动训练后的收缩功能和能力。细胞质Ca2+释放控制肌块收缩,通过电压敏感的质膜L型Ca2+通道和Ryanodine受体以及肌浆网Ca2+ATP酶进行重要调节。运动训练以增加和增强心脏收缩的方式增加和增强这些ECC子过程。此外,对运动训练的适应还包括肌丝Ca2+增敏。然后,有几个方面与运动后训练心肌细胞Ca2+的处理有关,这些方面仍然是推测性的和不确定的,但如果证明属实,可能具有特别重要的意义。这包括Ca2+连接的肌肉特异性基因转录以改变细胞结构和大小,还包括Ca2+循环和适应可能改变心律失常原性的情况。这篇综述文章讨论了心脏Ca2+适应运动训练的这些方面。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Current Opinion in Physiology
Current Opinion in Physiology Medicine-Physiology (medical)
CiteScore
5.80
自引率
0.00%
发文量
52
期刊最新文献
Revolutionizing therapeutics: unleashing the power of extracellular vesicles for disease intervention Sex-specific effects of environmental pollutants on pulmonary immune responses Circadian rhythms in renal metabolism Extracellular vesicles released by Trypanosoma cruzi and Leishmania spp.: protozoan parasite–host interaction mechanism Publisher's Note
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1