Using synbiotics supplementation to treat hepatic steatosis: A comprehensive meta-analysis of randomized controlled trials

IF 1.9 Q3 ENDOCRINOLOGY & METABOLISM Human Nutrition and Metabolism Pub Date : 2023-06-01 DOI:10.1016/j.hnm.2023.200194
Ammar Nojaid , Jason William , Krisanto Tanjaya , Nurpudji Astuti Taslim , Fahrul Nurkolis
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引用次数: 1

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease that occurs in a quarter of the global adult population. Thus far, NAFLD treatments are limited to lifestyle change and medicines with considerable adverse effects, with other novel treatment of choice, such as gut microbiota supplementation are currently being researched. This meta-analysis compares the effectiveness of prebiotics, probiotics, synbiotics, and placebo treatments for NAFLD-hepatic steatosis and has been written following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Assessment of the bias risk of the included studies used Cochrane Risk of Bias Tool 2. The literature search was conducted by five independent researchers from November 15, 2022, to December 20, 2022. Twenty studies, limited to English language publications, have been included in the qualitative synthesis, with nineteen of those also included in the quantitative synthesis using RevMan 5.4. The outcomes of interest are Liver Stiffness Measurement (LSM), serum Alanine transaminase (ALT), aspartate transaminase (AST), homeostatic model assessment for insulin resistance (HOMA-IR), and intrahepatic triglyceride (IHTG). Out of the five outcomes of interest, AST, ALT, and IHTG demonstrate statistically significant results, supporting the use of synbiotic supplements rather than the placebo treatment, but LSM and HOMA-IR producing statistically insignificant results. Synbiotic supplements may serve as an alternative treatment for hepatic steatosis patients with NAFLD due to its significant benefit in reducing AST, ALT, and IHTG. Further research combined with other treatment plan might be of interest in this treatment method.

This systematic review has been registered to the PROSPERO database (CRD42023392048).

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使用合成补剂治疗肝脂肪变性:一项随机对照试验的综合meta分析
非酒精性脂肪肝(NAFLD)是一种慢性肝病,发生在全球四分之一的成年人群中。到目前为止,NAFLD的治疗仅限于改变生活方式和具有相当大副作用的药物,目前正在研究其他新的治疗方法,如补充肠道微生物群。该荟萃分析比较了益生元、益生菌、合生元和安慰剂治疗NAFLD肝脂肪变性的有效性,并按照系统评价和荟萃分析的首选报告项目撰写。纳入研究的偏倚风险评估使用Cochrane偏倚风险工具2。文献检索由五名独立研究人员于2022年11月15日至2022年12月20日进行。20项研究,仅限于英文出版物,已被纳入定性综合,其中19项也被纳入使用RevMan 5.4的定量综合。感兴趣的结果是肝硬度测量(LSM)、血清丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、胰岛素抵抗稳态模型评估(HOMA-IR)和肝内甘油三酯(IHTG)。在感兴趣的五个结果中,AST、ALT和IHTG显示出统计学上显著的结果,支持使用合生元补充剂而不是安慰剂治疗,但LSM和HOMA-IR产生的结果在统计学上不显著。合生素补充剂可作为NAFLD肝脂肪变性患者的替代治疗方法,因为其在降低AST、ALT和IHTG方面具有显著益处。进一步的研究结合其他治疗方案可能对这种治疗方法感兴趣。该系统审查已登记到PROSPERO数据库(CRD42023392048)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Human Nutrition and Metabolism
Human Nutrition and Metabolism Agricultural and Biological Sciences-Food Science
CiteScore
1.50
自引率
0.00%
发文量
30
审稿时长
188 days
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