Advances in surface plasmon resonance biosensors for medical diagnostics: An overview of recent developments and techniques

Journal of Pharmaceutical and Biomedical Analysis Open Pub Date : 2023-09-09 DOI:10.1016/j.jpbao.2023.100019

G.I. Janith , H.S. Herath , N. Hendeniya , D. Attygalle , D.A.S. Amarasinghe , V. Logeeshan , P.M.T.B. Wickramasinghe , Y.S. Wijayasinghe

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引用次数: 1

Abstract

Over the last two decades, surface plasmon resonance (SPR) sensors have advanced significantly, becoming an important tool in disciplines such as biosensing, chemical sensing, and material characterization. SPR has gained popularity in biosensing because of its great sensitivity and specificity in detecting biomolecular interactions. This review provides an overview of the recent developments of the SPR biosensor technology and its applications in medical diagnostics. To provide an up-to-date overview of the area, the review includes the most recent works from the last decade. Furthermore, it explores various configurations (prism, grating, fiber optic, waveguide modulated) and wave properties (angle, wavelength, phase) being tracked for sensing together with strategies for enhancing sensitivity and selectivity through mechanisms such as surface coatings, sensing mediums, and immobilization techniques.

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用于医学诊断的表面等离子体共振生物传感器的进展:最新发展和技术综述

在过去的二十年里，表面等离子体共振(SPR)传感器取得了显著的进步，成为生物传感、化学传感和材料表征等学科的重要工具。SPR因其在检测生物分子相互作用方面具有很高的灵敏度和特异性而在生物传感领域得到了广泛的应用。本文综述了SPR生物传感器技术的最新进展及其在医学诊断中的应用。为了提供该领域的最新概况，该评论包括了过去十年的最新作品。此外，它还探讨了各种配置(棱镜，光栅，光纤，波导调制)和波的特性(角度，波长，相位)被跟踪用于传感，以及通过诸如表面涂层，传感介质和固定技术等机制提高灵敏度和选择性的策略。

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Journal of Pharmaceutical and Biomedical Analysis Open

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