Response of swine to inactivated foot-and-mouth disease vaccine

IF 2.5 4区医学 Q3 VIROLOGY Archives of Virology Pub Date : 1969-06-01 DOI:10.1007/BF01249381

P. D. McKercher, P. Gailiunas

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引用次数: 5

Abstract

Summary

The duration of immunity was studied for a 365-day period in swine vaccinated with a foot-and-mouth disease trivalent vaccine, inactivated for 48 hours with acetylethyleneimine and combined with an oil adjuvant. A satisfactory degree of immunity was afforded at 90 and 180 days postinoculation (DPI). At 365 DPI, vaccinated swine still maintained a degree of resistance to infection despite marked lowering of neutralizing antibody. At 6 months, lesions at inoculation sites were of very limited extent and appeared as scattered islands of small yellowish streaks of fibrous tissue and some spherical nodules. Histologically, lesions were multiple, foreign-body-type granulomas characterized by oil vacuoles, reticuloendothelial cell proliferation and fibrosis. Tissues surrounding lesions were normal. At 12 months, these lesions were almost impossible to locate. Microscopically, they were comparable to those observed at 6 months. Whether these lesions are more serious than those obtained with current products and other adjuvants and whether these constitute a carcass blemish remain to be determined.

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猪对口蹄疫灭活疫苗的反应

摘要研究了接种口蹄疫三价疫苗的猪365天的免疫持续时间，该疫苗用乙酰亚乙基亚胺灭活48小时，并与油佐剂联合使用。在麻醉后90和180天（DPI）提供了令人满意的免疫程度。在365 DPI时，接种疫苗的猪仍然保持一定程度的抗感染能力，尽管中和抗体显著降低。6个月时，接种部位的病变范围非常有限，表现为分散的岛状纤维组织小黄条纹和一些球形结节。组织学上，病变为多发性异物型肉芽肿，特征为油泡、网状内皮细胞增殖和纤维化。病变周围组织正常。12个月时，这些病变几乎无法定位。显微镜下，它们与6个月时观察到的结果相当。这些损伤是否比使用现有产品和其他佐剂获得的损伤更严重，以及这些损伤是否构成胴体缺陷还有待确定。

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来源期刊

Archives of Virology 医学-病毒学

CiteScore

5.10

自引率

7.40%

发文量

324

审稿时长

4.5 months

期刊介绍： Archives of Virology publishes original contributions from all branches of research on viruses, virus-like agents, and virus infections of humans, animals, plants, insects, and bacteria. Coverage spans a broad spectrum of topics, from descriptions of newly discovered viruses, to studies of virus structure, composition, and genetics, to studies of virus interactions with host cells, organisms and populations. Studies employ molecular biologic, molecular genetics, and current immunologic and epidemiologic approaches. Contents include studies on the molecular pathogenesis, pathophysiology, and genetics of virus infections in individual hosts, and studies on the molecular epidemiology of virus infections in populations. Also included are studies involving applied research such as diagnostic technology development, monoclonal antibody panel development, vaccine development, and antiviral drug development.Archives of Virology wishes to publish obituaries of recently deceased well-known virologists and leading figures in virology.